There are currently 1046 clinical trials in Aurora, Colorado looking for participants to engage in research studies. Trials are conducted at various facilities, including Children's Hospital Colorado, University of Colorado, University of Colorado Hospital and University of Colorado- Denver. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
International CDKL5 Clinical Research Network
NCT05558371
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
All
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of Colorado Denver/Children's Hospital Colorado, Aurora, Colorado
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
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Accuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss
NCT05887128
Recruiting
To compare the diagnostic accuracy of extra-oral x-rays with intra-oral x-rays, in contrast to clinically observed measurements, for the detection of calculus and bone loss of either the suprabony or infrabony types in patients undergoing periodontal surgery.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
12/04/2023
Locations: Univeristy of Colorado School of Dental Medicine Dental Clinic, Aurora, Colorado
Conditions: Periodontitis, Calculus, Dental, Bone Loss, Alveolar
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Improving P. Aeruginosa Detection With Breath-based Diagnostics (IMPACT-Breath)
NCT04735952
Recruiting
The study is a breath biomarker validation study. It is anticipated that 300 patients with cystic fibrosis (CF) from 5 clinical sites in the USA will be enrolled. The study is funded by the US NIH and the US Cystic Fibrosis Foundation. Enrollment commenced in May 2019. Sputum, induced sputum, and oropharyngeal swabs will be collected and evaluated at each clinic as part of standard clinical practice. Excess sputum will be sent to Children's Colorado Hospital for molecular analysis. No swabs will... Read More
Gender:
All
Ages:
3 years and above
Trial Updated:
12/02/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Cystic Fibrosis
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Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction
NCT05870982
Recruiting
The goal of this clinical trial is to learn about time restricted eating as a weight loss intervention in adults with obesity. The main questions it aims to answer are: How does the timing of the eating window (early vs late time restricted eating) affect weight loss and changes in metabolic risk factors? How does time restricted eating compare to standard of care (daily caloric restriction) for weight loss and changes in metabolic risk factors? Participants will be randomly assigned to either... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2023
Locations: University of Colorado Anschutz Health and Wellness Center, Aurora, Colorado
Conditions: Overweight and Obesity
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Sedentary Behavior in Older Women With and Without Type 2 Diabetes
NCT04262128
Recruiting
Sedentary behavior has been linked to cardiovascular morbidity and mortality, and is particularly common in older adults with type 2 diabetes. The purpose of this observational, mixed-methods study is to better understand the relationship between prolonged sedentary behavior and cardiovascular and metabolic health in older women.
Gender:
Female
Ages:
Between 60 years and 75 years
Trial Updated:
12/01/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Diabetes Mellitus, Type 2, Healthy
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A Comparison of Two School Based Interventions to Manage Anxiety in Autistic Students
NCT05863520
Recruiting
The goal of this clinical trial is to compare two school based interventions to manage anxiety in autistic students. The main question[s] it aims to answer are: 1) Compare the effectiveness of Facing Your Fears-School Based Program (FYF-SB) with Zones of Regulation (ZOR) on anxiety reduction and emotion regulation; and 2) examine the feasibility and satisfaction of FYF-SB and ZOR, according to students, caregivers and school providers. Autistic students with anxiety between 8-14 years will be ra... Read More
Gender:
All
Ages:
Between 7 years and 15 years
Trial Updated:
11/28/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Autism Spectrum Disorder, Anxiety Disorders, Emotion Regulation
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Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
NCT03297775
Recruiting
The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g. clinical features, genetic variants, and/or biologic markers) between other forms of ILD (e.g. idiopathic pulmonary fibrosis, IPF) and subclinical RA-ILD that places individuals at risk for the devel... Read More
Gender:
All
Ages:
Between 45 years and 90 years
Trial Updated:
11/28/2023
Locations: University of Colorado - Anschutz Medical Campus, Aurora, Colorado
Conditions: Rheumatoid Arthritis, Interstitial Lung Disease
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Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
NCT04059172
Recruiting
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a placebo. The hypothesis is that combined ibuprofen and acetaminophen therapy will effectively provide better pain control than ibuprofen alone or a placebo after orthodontic appliance placement.
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
11/28/2023
Locations: University of Colorado, School of Dental Medicine, Aurora, Colorado
Conditions: Pain, Orofacial
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Comparison of Patient-reported Pain After Initial Archwire Placement
NCT03906422
Recruiting
Three different types of 'archwires' can be used in Orthodontic treatment, wire choice is decided by treating Orthodontist based on professional preference since research shows that all types are equally effective. It is possible that one type of wire engenders more patient discomfort. This study will compare the discomfort levels engendered by the three wire types to determine if there is one that induces the least amount.
Gender:
All
Ages:
12 years and above
Trial Updated:
11/28/2023
Locations: University of Colorado School of Dental Medicine, Aurora, Colorado
Conditions: Orthodontic Discomfort, Pain, Orofacial
Register for Updates
Food Intake and the Adolescent Brain
NCT04208256
Recruiting
The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.
Gender:
All
Ages:
Between 13 years and 18 years
Trial Updated:
11/28/2023
Locations: University of Colorado, Aurora, Colorado
Conditions: Feeding Behavior, Brain, Adolescent
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Identification of Best Postoperative Analgesia Method Following a Minimally Invasive Repair of Pectus Excavatum
NCT04211935
Recruiting
Pectus excavatum is the most common chest wall deformity in children, accounting for 90% of all congenital chest wall deformities. It occurs in one to eight per 1000 live births. The severity of the pectus deformity may become more noticeable during pubertal growth spurs and repair is therefore usually performed in the teenage years. A common operative procedure to repair a pectus deformity is the minimally invasive repair of pectus excavatum (MIRPE). The MIRPE involves the substernal placement... Read More
Gender:
All
Ages:
Between 13 years and 18 years
Trial Updated:
11/28/2023
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Pectus Excavatum, Pain, Postoperative
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The Pediatric Anesthesia Quality Improvement Project
NCT00674388
Recruiting
The Study is designed to collect information about adverse events that occur in children undergoing anesthesia in participating hospitals. Demographic information will be collected on all anesthetics. An analysis of each adverse event will be performed and entered into the database. From this information we will devise strategies to prevent these adverse events.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
11/20/2023
Locations: Colorado Children's Hospital, Aurora, Colorado
Conditions: Surgery, Anesthesia, Children
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