There are currently 70 active clinical trials seeking participants for Coronary Artery Disease research studies. The states with the highest number of trials for Autism participants are California, Florida, New York and Texas.
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
NCT06374277
Recruiting
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of readmissions and costs among these patients. Major patient-reported barriers to essential medication use after hospital discharge among low-income individuals are related to social determinants of healt... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: University of Tennessee Medical Center, Knoxville, Tennessee +1 locations
Conditions: Diabetes, Hypertension, High Cholesterol/Hyperlipidemia, Coronary Artery Disease, Congestive Heart Failure, Chronic Lung Disease, Chronic Kidney Diseases, Arrythmia, Stroke, Depression, Anxiety, Pulmonary Embolism, Heart Attack
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Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention
NCT06228456
Recruiting
The proposed study aims to assess the antiplatelet effects of more potent oral P2Y12 inhibition with low-dose ticagrelor (60 mg bid) compared with standard of care clopidogrel in patients with a high ABCD-GENE score (≥10). We hypothesize that ticagrelor is associated with better pharmacodynamic effects (i.e., lower platelet reactivity and high platelet reactivity rates) compared with clopidogrel in stable coronary artery disease patients undergoing percutaneous coronary intervention with a high... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: University of Florida Jacksonville, Jacksonville, Florida
Conditions: Coronary Artery Disease
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Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)
NCT06280976
Recruiting
The purpose of this study is to evaluate the role of coronary CT angiogram (CCTA) as a superior guide for the assessment of coronary artery plaque and guiding treatment decisions. We will also assess the impact of preventive cardiovascular drugs on the plaque to improve patient outcomes. Participants aged 18-80 years, at intermediate or high-risk for coronary artery disease, with non-obstructive plaque on initial CCTA, will be enrolled in this study. They will be randomized into Standard of Care... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/22/2024
Locations: University of Louisville School of Medicine, Division of Cardiovascular Diseases, Louisville, Kentucky
Conditions: Coronary Artery Disease, Atherosclerosis, Heart Attack
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The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
NCT05427370
Recruiting
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether C... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Mayo Clinic, Rochester, Minnesota +22 locations
Conditions: Coronary Artery Disease, Heart Failure Systolic
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Study of Hepatitis Eradication Receiving Protease Inhibitor Administration
NCT03886077
Recruiting
This is a prospective, non-blinded cohort study that will assess the safety, tolerability, and antiviral efficacy of glecaprevir/pibrentasivir therapy given post-discharge to HCV-negative recipients of HCV infected donors. Patients who meet entry criteria will be enrolled while on the transplant waitlist. At the time of transplant, some donors will be HCV positive / NAT positive and some will not be infected. Enrolled patients who receive an HCV negative donor will serve as contemporaneous contr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Coronary Artery Disease, Morality
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Impact of a Corrie Cardiac Rehabilitation Program
NCT05238103
Recruiting
In this randomized clinical trial, the researchers are investigating whether a multi-component virtual/hybrid cardiac rehabilitation program will improve functional status, cholesterol level, overall cardiovascular health, individual risk factors, quality of life and mental health for patients who have recently been diagnosed with myocardial infarction, received a coronary stent, underwent heart surgery or catheter-based valve replacement, as compared to usual care.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Coronary Artery Disease, Myocardial Infarction, Myocardial Ischemia, Coronary Artery Occlusion, Coronary Artery Stenosis Stent, Bypass Graft Occlusion, Valve Heart Disease
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RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)
NCT05134012
Recruiting
This a Phase 3, prospective, open-label, multicenter study of [15-O]-H2O injection for PET imaging of subjects with suspected CAD. Approximately 182 evaluable participants with suspected CAD referred for testing will be included in the study at approximately 10 study sites in the United States and Europe. Approximately 215 participants will be enrolled to account for an estimated 15% drop-out rate. Screening assessments will occur prior to enrollment to confirm eligibility. All participants will... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/16/2024
Locations: University of Iowa, Iowa City, Iowa +10 locations
Conditions: Coronary Artery Disease
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Evaluating Infrasonic Hemodynography
NCT04636892
Recruiting
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
Gender:
All
Ages:
All
Trial Updated:
04/15/2024
Locations: Scripps Health, La Jolla, California
Conditions: Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic, Cardiovascular Diseases, Coronary Artery Disease
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Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
NCT04920799
Recruiting
Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with CAD.
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
04/12/2024
Locations: Integrative Cardiovascular Physiology Laboratory, University of Florida, Gainesville, Florida
Conditions: Coronary Artery Disease
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The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI
NCT04316676
Recruiting
The overall goal of this project is to compare the absolute quantification of myocardial perfusion done by using CT myocardial perfusion imaging (CT-MPI) and the coronary flow measured by using CT Fractional Flow Reserve analysis (CT-FFR) to the gold standard represented by PET myocardial perfusion imaging (PET-MPI).
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/11/2024
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Coronary Artery Disease
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Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)
NCT05966662
Recruiting
This investigational device exemption (IDE) study is to assess the safety and effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary lesions prior to stenting.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2024
Locations: Heart Center Research, Huntsville, Alabama +11 locations
Conditions: Coronary Artery Disease, Myocardial Infarction
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Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
NCT05360446
Recruiting
CKJX839D12303 is a research study to determine if the study treatment, called inclisiran, in comparison to placebo taken in addition to statin medication can effectively reduce the total amount of plaque formed in the heart's vessels as measured by coronary computed tomography angiography (CCTA) from baseline to month 24. This study is being conducted in eligible participants with a diagnosis of non-obstructive coronary artery disease (NOCAD), where the coronary arteries are blocked less than 50... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/04/2024
Locations: Heart Center Research Llc ., Huntsville, Alabama +102 locations
Conditions: Coronary Artery Disease
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