Coronary Artery Disease Clinical Trials

A listing of 72 Coronary Artery Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 72 active clinical trials seeking participants for Coronary Artery Disease research studies. The states with the highest number of trials for Coronary Artery Disease participants are California, Florida, New York and Texas.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Clinical Study

Recruiting

We are evaluating an investigational treatment to see if it may help people dealing with chronic cough.
Eligible participants will receive study-related medical care at no cost. You may be compensated for study-related travel and time. Health insurance is not required. If you qualify, you may receive:
Payment up to $1500, which varies by study.

Conditions:

Cough

Chronic Cough

Asthma

Allergic Asthma

Sinusitis

Learn More

Featured Trial

Healthy Volunteer Trials

Recruiting

Healthy trials near you are looking for participants to help push medical research forward. Click through to learn more!

Conditions:

Healthy

Learn More

Featured Trial

Healthy Volunteer Clinical Studies

Recruiting

Find a study looking for volunteers at a study site near you! Some trials offer compensation for time and travel. Click through to learn more about study opportunities.

Conditions:

Healthy

Healthy Volunteers

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Liraglutide Effects on Epicardial Fat Inflammatory Genes

NCT03260881

Recruiting

Epicardial adipose tissue (EAT) is the visceral fat of the heart. EAT could locally affect the coronary arteries through local secretion of pro-inflammatory cytokines. EAT plays a role in the development of the coronary artery disease (CAD). EAT is a highly enriched with genes involved in inflammation. Given its rapid metabolism and simple measurability, as first developed by Iacobellis, EAT serves as target for medications targeting the fat. Glucagon-like peptide-1 agonists (GLP-1A) are anti-diabetic medications with recently suggested cardio-protective properties. Liraglutide, a GLP-1A, has recently shown to reduce the cardiovascular risk. Iacobellis'group found that EAT thickness decreased by an unprecedented 36% after 12 weeks of treatment with liraglutide. Remarkably, Iacobellis'group found for the first time that human EAT express GLP-1 Receptor (GLP-1R). GLP-1A effects may be therefore visceral fat specific and target EAT. Based on these preliminary data, we hypothesize that treatment with liraglutide will significantly and rapidly reduce EAT inflammation. Decreased EAT inflammation can reduce the burden of the coronary plaques. We will test our hypothesis in a 12-week randomized, double-blind, placebo-controlled, interventional study in 40 patients with type 2 diabetes mellitus (T2DM), and CAD, with an acceptable glycemic control on their current diabetes regimen who require elective coronary artery bypass graft (CABG) regardless of their participation in the study. A minimum time frame of 4-week treatment will be considered to detect significant changes in the study endpoints. Inclusion criteria for body fat markers will rule out the confounding effect of different body fast distribution at baseline. Study subjects will be randomized in two groups of 20 patients to receive additional liraglutide or to remain on current treatment/ placebo prior to cardiac surgery. CAD subjects not allocated to liraglutide will be started on a supervised low calorie diet (LCD) to achieve approximately 5% of weight loss after from a minimum of 4 weeks up to 12 weeks to avoid the confounding effect of weight loss on the study outcomes. EAT samples will be collected during cardiac surgery and processed for analysis of mRNA and protein expression of EAT inflammatory genes such as Tumor Necrosis Factor-alpha (TNF-α) and Interleukin 6 (IL-6), and GLP-1R. Read Less

Gender:

All

Ages:

18 years and above

Trial Updated:

06/20/2024

Locations: University of Miami, Miami, Florida

Conditions: Type2 Diabetes, Coronary Artery Disease

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Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

NCT05966662

Recruiting

This investigational device exemption (IDE) study is to assess the safety and effectiveness of the Shockwave Coronary Intravascular Lithotripsy (IVL) System with the Shockwave C2+ 2Hz Coronary IVL Catheter to treat de novo, calcified, stenotic, coronary lesions prior to stenting.

Gender:

All

Ages:

18 years and above

Trial Updated:

06/20/2024

Locations: Heart Center Research, Huntsville, Alabama +14 locations

Conditions: Coronary Artery Disease, Myocardial Infarction

Learn More ›

Product Surveillance Registry

NCT01524276

Recruiting

The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.

Gender:

All

Ages:

All

Trial Updated:

06/13/2024

Locations: Not set, Birmingham, Alabama +362 locations

Not set, Birmingham, Alabama

Not set, Huntsville, Alabama

Not set, Anchorage, Alaska

Not set, Chandler, Arizona

Not set, Phoenix, Arizona

Not set, Jonesboro, Arkansas

Not set, Little Rock, Arkansas

Not set, Aliso Viejo, California

Not set, Carlsbad, California

Not set, Chula Vista, California

Not set, Colton, California

Not set, Los Angeles, California

Not set, Napa, California

Not set, Rancho Mirage, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Van Nuys, California

Not set, Ventura, California

Not set, Aurora, Colorado

Not set, Colorado Springs, Colorado

Not set, Lakewood, Colorado

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Davie, Florida

Not set, Jacksonville, Florida

Not set, Naples, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Weston, Florida

Not set, Gainesville, Georgia

Not set, Chicago, Illinois

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, Iowa City, Iowa

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, New Orleans, Louisiana

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Boston, Massachusetts

Not set, Holyoke, Massachusetts

Not set, Ann Arbor, Michigan

Not set, Lansing, Michigan

Not set, Rochester Hills, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Jackson, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, Saint Louis, Missouri

Not set, Omaha, Nebraska

Not set, Lebanon, New Hampshire

Not set, Camden, New Jersey

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, Ocean Township, New Jersey

Not set, Teaneck, New Jersey

Not set, Albuquerque, New Mexico

Not set, Albany, New York

Not set, Bay Shore, New York

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, Mount Kisco, New York

Not set, New Hyde Park, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Riverhead, New York

Not set, Roslyn, New York

Not set, Staten Island, New York

Not set, Stony Brook, New York

Not set, Utica, New York

Not set, Chapel Hill, North Carolina

Not set, Durham, North Carolina

Not set, Pinehurst, North Carolina

Not set, Raleigh, North Carolina

Not set, Winston-Salem, North Carolina

Not set, Akron, Ohio

Not set, Cincinnati, Ohio

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Dayton, Ohio

Not set, Mount Orab, Ohio

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Mechanicsburg, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Charleston, South Carolina

Not set, Columbia, South Carolina

Not set, Orangeburg, South Carolina

Not set, Spartanburg, South Carolina

Not set, Sioux Falls, South Dakota

Not set, Germantown, Tennessee

Not set, Memphis, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Fort Worth, Texas

Not set, Houston, Texas

Not set, Plano, Texas

Not set, San Antonio, Texas

Not set, Tyler, Texas

Not set, Salt Lake City, Utah

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Fairfax, Virginia

Not set, Fredericksburg, Virginia

Not set, Bremerton, Washington

Not set, Seattle, Washington

Not set, Spokane, Washington

Not set, Morgantown, West Virginia

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Buenos Aires, Not set

Not set, Westmead, New South Wales

Not set, Chermside, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Aalst, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Gent, Not set

Not set, Leuven, Not set

Not set, Liege, Not set

Not set, Roeselare, Not set

Not set, São Paulo, Not set

Not set, Calgary, Alberta

Not set, Kingston, Ontario

Not set, Montreal, Quebec

Not set, Quebec City, Not set

Not set, Quebec, Not set

Not set, Toronto, Not set

Not set, Chengdu, Sichuan

Not set, Beijing, Not set

Not set, Changsha, Not set

Not set, Dalian, Not set

Not set, Fuzhou, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Shantou, Not set

Not set, Suzhou, Not set

Not set, Taiyuan, Not set

Not set, Tianjin, Not set

Not set, Cartagena, Not set

Not set, Medellin, Not set

Not set, Pereira, Not set

Not set, Rionegro, Not set

Not set, Praha, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Kobenhavn, Not set

Not set, Odense, Not set

Not set, Helsinki, Not set

Not set, Tampere, Not set

Not set, Avignon, Not set

Not set, Bayonne, Not set

Not set, Bordeaux, Not set

Not set, Boulogne-Billancourt, Not set

Not set, Brest Cedex, Not set

Not set, Caen, Not set

Not set, Chambray, Not set

Not set, Clermont Ferrand, Not set

Not set, Créteil, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille Cedex, Not set

Not set, Marseille Cedex 5, Not set

Not set, Montpellier Cedex 5, Not set

Not set, Nantes, Not set

Not set, Neuilly-sur-Seine, Not set

Not set, Ollioules, Not set

Not set, Paris, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Bad Oeynhausen, Not set

Not set, Bremen, Not set

Not set, Düsseldorf, Not set

Not set, Essen, Not set

Not set, Frankfurt am main, Not set

Not set, Freiburg, Not set

Not set, Hagen, Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Jena, Not set

Not set, Karlsruhe, Not set

Not set, Köln, Not set

Not set, Leipzig, Not set

Not set, Lübeck, Not set

Not set, Munster, Not set

Not set, München, Not set

Not set, Ulm, Not set

Not set, Wiesbaden, Not set

Not set, Athens, Not set

Not set, Maroúsi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Hyderabad, Telangana

Not set, Chennai, Not set

Not set, New Delhi, Not set

Not set, Galway, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Acquaviva Delle Fonti, Not set

Not set, Ancona, Not set

Not set, Bassano Del Grappa, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Castrovillari, Not set

Not set, Chieri, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Palermo, Not set

Not set, Pavia, Not set

Not set, Roma, Not set

Not set, Rome, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Vimercate, Not set

Not set, Sakai, Osaka

Not set, Ageo, Saitama

Not set, Hidaka, Saitama

Not set, Koshigaya, Saitama

Not set, Tokyo, Tachikawa

Not set, Bunkyō-Ku, Tokyo

Not set, Minato-Ku, Tokyo

Not set, Yonago, Tottori

Not set, Chiba, Not set

Not set, Fukuoka, Not set

Not set, Gifu, Not set

Not set, Hirosaki, Not set

Not set, Hiroshima City, Not set

Not set, Hiroshima, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Kumamoto, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Yangsan, Gyeongsangnam-do

Not set, Busan, Not set

Not set, Changwon, Not set

Not set, Cheongju-si, Not set

Not set, Daegu, Not set

Not set, Daejeon, Not set

Not set, Gangneung, Not set

Not set, Gwangju, Not set

Not set, Gyeonggi-do, Not set

Not set, Incheon, Not set

Not set, Jeonju, Not set

Not set, Seongnam-si, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Ciudad de mexico, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Heerlen, Not set

Not set, Hengelo, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Oslo, Not set

Not set, Trondheim, Not set

Not set, Poznań, Not set

Not set, Warszawa, Not set

Not set, Zabrze, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Aibonito, Not set

Not set, Rio Piedras, Not set

Not set, Jeddah, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, L'Hospitalet De Llobregat, Not set

Not set, Madrid, Not set

Not set, Málaga, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago De Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Göteborg, Not set

Not set, Lund, Not set

Not set, Skövde, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneve, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Morges, Not set

Not set, Zürich, Not set

Not set, Barnstaple, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Newcastle Upon Tyne, Not set

Not set, Northampton, Not set

Not set, Nottingham, Not set

Not set, Sheffield, Not set

Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency, Neurovascular, Coronary Artery Disease, Ear, Nose and Throat Disorder

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The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

NCT05427370

Recruiting

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether C... Read More

Gender:

All

Ages:

18 years and above

Trial Updated:

06/07/2024

Locations: UofL Health, Inc, Louisville, Kentucky +25 locations

UofL Health, Inc, Louisville, Kentucky

Mayo Clinic, Rochester, Minnesota

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Medical University of Vienna, Vienna, Not set

Institute of Cardiology, Porto Alegre, Not set

University of Calgary; Libin Cardiovascular Institute, Calgary, Alberta

Fraser Health; Royal Columbian Hospital, New Westminster, British Columbia

Queen Elizabeth II Hospital, Halifax, Nova Scotia

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences Center, University Hospital, London, Ontario

Southlake Regional HC, Newmarket, Ontario

Sunnybrook Health Sciences Center, Toronto, Ontario

St. Michael's, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Center Hospitalier Universitaire de Montreal, Montréal, Quebec

Montreal Heart Institute, Montréal, Quebec

Jewish General Hospital, Montréal, Quebec

Hospital Sacre-Coeur, Montréal, Quebec

Institut de Cardiologie Quebec (QC) - Laval, Québec, Quebec

Jilin Heart Hospital, Jilin, Changchun

Clinical Hospital Dubrava, Sušak, Zagreb

G Kuppuswamy Naidu Memorial Hospital (GKNM), Palayam, Tamil Nadu

European Hospital, Via Portuense, Roma, RM

Medical University of Silesia, Katowice, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

Hospital del Vinalopó, Alicante, Not set

Conditions: Coronary Artery Disease, Heart Failure Systolic

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Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease

NCT05755711

Recruiting

Post-market, prospective, multi-center, single-arm observational study to generate real-world clinical evidence associated with coronary IVL in a population of female subjects with calcified coronary artery disease.

Gender:

Female

Ages:

18 years and above

Trial Updated:

06/07/2024

Locations: Loma Linda University Health, Loma Linda, California +38 locations

Loma Linda University Health, Loma Linda, California

Good Samaritan Hospital, Los Angeles, California

Kaiser Permanente - San Francisco Medical Center, San Francisco, California

South Denver Cardiology Associates, P.C, Littleton, Colorado

Yale New Haven Hospital, New Haven, Connecticut

Morton Plant Hospital, Clearwater, Florida

Tallahassee Research Institute, Tallahassee, Florida

Emory Hospital, Atlanta, Georgia

Piedmont Heart Institute, Atlanta, Georgia

Northside Hospital, Atlanta, Georgia

Northwestern University, Evanston, Illinois

University of Kansas Medical Center, Kansas City, Kansas

Tulane University Center for Clinical Research, New Orleans, Louisiana

Massachusetts General Hospital, Boston, Massachusetts

Brigham and Women's Hospital, Boston, Massachusetts

UNMC Heart & Vascular Research Office, Omaha, Nebraska

New England Heart and Vascular Institute, Manchester, New Hampshire

Montefiore Medical Center, Bronx, New York

NYU Langone Health, Brooklyn, New York

NYU Langone Health, New York, New York

Columbia University Medical Center, New York, New York

St. Francis Hospital, Roslyn, New York

The Lindner Center for Research and Education at The Christ Hospital CRA: Timothy, Cincinnati, Ohio

WellSpan York Hospital, York, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

MUSC Health University Medical Center, Charleston, South Carolina

Centennial Heart, Nashville, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

DHR Health Heart Institute, McAllen, Texas

Baylor Scott & White Research Institute, Plano, Texas

Inova Fairfax Medical Campus, Falls Church, Virginia

University of Washington Medical Center, Seattle, Washington

Clinique Pasteur, Toulouse, Bp 27617

Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz, Mainz, Langenbeckstr. 1

Krankenhaus der Barmherzigen Bruder Trier, Trier, Nordallee 1

Hospital Clinico De Santiago, Santiago De Compostela, A Coruña

Hospital del Mar, Barcelona, Not set

Hospital Universitario Reina Sofia, Córdoba, Not set

Hospital Clínico San Carlos, Madrid, Not set

Conditions: Coronary Artery Disease

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RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

NCT05134012

Recruiting

This a Phase 3, prospective, open-label, multicenter study of [15-O]-H2O injection for PET imaging of subjects with suspected CAD. Approximately 182 evaluable participants with suspected CAD referred for testing will be included in the study at approximately 10 study sites in the United States and Europe. Approximately 215 participants will be enrolled to account for an estimated 15% drop-out rate. Screening assessments will occur prior to enrollment to confirm eligibility. All participants will... Read More

Gender:

All

Ages:

18 years and above

Trial Updated:

06/03/2024

Locations: University of Iowa, Iowa City, Iowa +10 locations

Conditions: Coronary Artery Disease

Learn More ›

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

NCT04763200

Recruiting

The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health after a heart procedure compared to the current standard of care.

Gender:

All

Ages:

Between 18 years and 90 years

Trial Updated:

05/29/2024

Locations: University of Alabama, Birmingham, Alabama +123 locations

University of Alabama, Birmingham, Alabama

Abrazo Arizona Heart, Phoenix, Arizona

St. Joseph's Medical Center - Phoenix, Phoenix, Arizona

Tucson Medical Center HealthCare, Tucson, Arizona

Northwest Medical Center Tucson, Tucson, Arizona

Washington Regional Medical Center - Walker Heart Institute, Fayetteville, Arkansas

Arkansas Cardiology, Little Rock, Arkansas

Mills-Peninsula Medical Center, Burlingame, California

Saint Agnes Medical Center, Fresno, California

Adventist Health Glendale, Glendale, California

Cedars-Sinai Medical Center, Los Angeles, California

St. Joseph Hospital - Orange, Orange, California

Loma Linda University Health, San Bernardino, California

UCSD Medical Center, San Diego, California

Torrance Memorial Medical Center, Torrance, California

Colorado Heart and Vascular, Lakewood, Colorado

MedStar Washington Hospital Center, Washington, District of Columbia

Cardiology Associates Research Company, Daytona Beach, Florida

The Cardiac & Vascular Institute, Gainesville, Florida

University of Florida Health - Gainesville, Gainesville, Florida

UF Health Jacksonville, Jacksonville, Florida

AdventHealth - Tampa, Tampa, Florida

Emory University Hospital, Atlanta, Georgia

Northside Cardiovascular Institute, Lawrenceville, Georgia

Wellstar Kennestone Hospital, Marietta, Georgia

The Queen's Medical Center, Honolulu, Hawaii

Rush University Medical Center, Chicago, Illinois

NorthShore University Health System, Evanston, Illinois

Northwestern University, Evanston, Illinois

Advocate Christ Medical Center, Oak Lawn, Illinois

Memorial Medical Center, Springfield, Illinois

Norton Healthcare - Norton Heart Specialists, Louisville, Kentucky

Cardiovascular Institute of the South (Lafayette General Medical Center), Lafayette, Louisiana

Ochsner Foundation Hospital, New Orleans, Louisiana

Tufts Medical Center, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

Henry Ford Hospital, Detroit, Michigan

Ascension St. John Hospital, Detroit, Michigan

Spectrum Health, Grand Rapids, Michigan

Metropolitan Heart and Vascular Institute / Metropolitan Cardiology Consultants, Coon Rapids, Minnesota

CentraCare (St. Cloud Hospital), Saint Cloud, Minnesota

SSM Health DePaul Hospital, Bridgeton, Missouri

St. Luke's Hospital, Kansas City, Missouri

Missouri Baptist Medical Center, Saint Louis, Missouri

Catholic Medical Center, Manchester, New Hampshire

Englewood Hospital, Englewood, New Jersey

Hackensack University Medical Center, Hackensack, New Jersey

Morristown Medical Center, Morristown, New Jersey

Jersey Shore University Medical Center, Neptune, New Jersey

Robert Wood Johnson Medical School & Robert Wood Johnson University Hospital, New Brunswick, New Jersey

The Valley Hospital - Ridgewood, Ridgewood, New Jersey

Lovelace/New Mexico Heart Institute, Albuquerque, New Mexico

Montefiore Medical Center - Moses, Bronx, New York

University at Buffalo/Kaleida Health, Buffalo, New York

Northwell University Hospital, Manhasset, New York

NYU Langone Health, New York, New York

Icahn School of Medicine at Mt. Sinai, New York, New York

Columbia University Medical Cenrer/NYPH, New York, New York

St. Francis Hospital and Heart Center, Roslyn, New York

Stony Brook University Hospital (SUNY), Stony Brook, New York

Sanger Heart and Vascular Institute, Charlotte, North Carolina

North Carolina Heart and Vascular Research, Raleigh, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Linder Research Center (The Christ Hospital), Cincinnati, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

University of Oklahoma Medical Center, Oklahoma City, Oklahoma

Providence St. Vincent Medical Center, Portland, Oregon

Legacy Emanuel Hospital & Health Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Health Network, Allentown, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

WellSpan York Hospital, York, Pennsylvania

Greenville Hospital System, Greenville, South Carolina

Monument Health Clinical Research, Rapid City, South Dakota

Wellmont Cardiology Services, Kingsport, Tennessee

Parkwest Medical Center, Knoxville, Tennessee

Centennial Heart - Nashville, Nashville, Tennessee

Ascension St. Thomas West, Nashville, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Presbyterian Hospital Dallas / Texas Health Physicians Group, Dallas, Texas

Medical City Fort Worth, Fort Worth, Texas

University of Texas Medical Branch (UTMB) Galveston, Galveston, Texas

HCA Houston Healthcare, Houston, Texas

Memorial Hermann Texas Medical Center (UT Health), Houston, Texas

Texas Heart Institute at Baylor St. Luke's Hospital, Houston, Texas

Texas Cardiology Associates of Houston, Kingwood, Texas

Baylor Scott & White Heart - Plano, Plano, Texas

Methodist Hospital - San Antonio, San Antonio, Texas

Sentara Norfolk Health System, Norfolk, Virginia

VCU Medical Center, Richmond, Virginia

Carilion Clinic, Roanoke, Virginia

University Of Washington Medical Center, Seattle, Washington

West Virginia University Hospital, Morgantown, West Virginia

Aurora St. Luke's Medical Center, Milwaukee, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

St. Boniface Hospital, Winnipeg, Manitoba

Toronto General Hospital, Toronto, Ontario

Klinikum rechts der Isar der TUM, Munich, Bavaria

Universitätsklinikum Erlangen, Erlangen, Bayern

Klinikum Karlsburg, Karlsburg, Mecklenburg-Vorpommern

Universitätsklinikum Düsseldorf, Düsseldorf, NRW

Krankenhaus der Barmherzigen Brüder, Trier, Rheinland-Pfalz

University Hospital Aachen, Aachen, Not set

Universitätsklinikum Freiburg, Universitäts-Herzzentrum, Bad Krozingen, Not set

Segeberger Kliniken GmbH, Bad Segeberg, Not set

Berlin CBF, Berlin, Not set

CVK Berlin, Berlin, Not set

Klinikum Chemnitz gGmbH, Chemnitz, Not set

Herzzentrum Dresden GmbH, Dresden, Not set

Universitätsklinikum Essen AöR, Essen, Not set

Klinikum Friedrichshafen GmbH, Friedrichshafen, Not set

Universitätsklinikum Gießen, Gießen, Not set

St. Vinzenz-Hospital Gmbh Köln, Köln, Not set

Uniklinik Würzburg, Würzburg, Not set

Humanitas Clinical & Research Hospital, Rozzano, Lombardy

Policlinico Universitario Agostino Gemelli, Rome, RM

Clinica Mediterranea, Napoli, Not set

Catharina Ziekenhuis Eindhoven, Eindhoven, North Brabant

LUMC-Leids Universitair Medisch Centrum, Leiden, Zuid

Istituto Cardiocentro Ticino, Lugano, Tessin

Inselspital Bern, Bern, Not set

Luzerner Kantonsspital, Luzern, Not set

Royal Brompton Hospital, London, Not set

Conditions: Left Ventricular Dysfunction, Coronary Artery Disease

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Polypill in Acute Coronary Syndrome

NCT05514938

Recruiting

Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low. This contributes to worse patient outcomes and increased risk of morbidity and mortality. The once-daily polypill leverages a population-based strategy that has previously demonstrated efficacy in improving adherence and access to therapy in low-resource settings, making it an innovative approach for improving post-ACS ca... Read More

Gender:

All

Ages:

18 years and above

Trial Updated:

05/28/2024

Locations: UT Southwestern Medical Center, Dallas, Texas

Conditions: Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease

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Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.

NCT03972774

Recruiting

The cost of medical care in the United States far exceeds that of all other advanced economies and continues to accelerate at a rate unacceptable to our society, due primarily to the high costs of new imaging technologies and novel drugs (1). Cardiac positron emission tomography (PET) imaging is a powerful new modality for the non-invasive detection of provocable coronary ischemia in patients with low to intermediate-risk chest pain or its equivalent. Intermountain Medical Center (IMC) is performing approximately 6000 clinical cardiac PET scans annually. However, cardiac PET scans are expensive (i.e., billed at >$5,000/scan, average receivable revenue $1500-$2000/scan). Coronary artery calcium (CAC) is a sensitive marker of coronary atherosclerosis. A CAC scan (CACS), performed by multislice computed tomography (CT), is a relatively inexpensive (~$70-$150/scan), low-radiation dose test that marks the presence of coronary atherosclerotic plaque. The absence of CAC has been shown to be associated with very low coronary risk. ACCURATE will test whether a CAC-first strategy (i.e., risk stratification, when CAC ≤ 1, to medical management or to cardiac PET stress testing), performed routinely in symptomatic patients presenting for evaluation of possible coronary artery disease (CAD) prior to the cardiac PET stress test, can be used as a gatekeeper for progression to the expensive rubidium-PET stress (regadenoson) perfusion scan and be a major cost-saver without adversely affecting patient care or outcomes. Routinely, qualifying patients undergo CACS when they present for evaluation of possible but unknown CAD status and are referred for cardiac PET stress testing. In ACCURATE, those with CACS≤1 will then be consented and randomized to either a cardiac PET stress test strategy or a non-PET-driven medical care strategy. Subjects randomized to the cardiac PET stress test strategy will receive appropriate subsequent care depending on the outcome of the cardiac PET scan (i.e., depending on whether ischemia is present or not). Subjects randomized to the CAC-only arm will receive appropriate non-PET driven medical clinical management and follow-up. All participating subjects' electronic medical records will be reviewed indefinitely for clinical outcomes. Initial outcomes will be reported at 1-year, 2-years, and 5-years, with future analyses to be determined by the study investigators. The objective of this study is to test the hypothesis that PET stress test strategy will results in a decreasing in major adverse cardiac endpoint without exceeding $100,000 per quality-adjusted life year compared to a CAC-first strategy for screening suspected/possible coronary artery disease. Read Less

Gender:

All

Ages:

50 years and above

Trial Updated:

05/23/2024

Locations: Intermountain Healthcare Hospitals and Clinics, Salt Lake City, Utah

Conditions: Coronary Artery Disease

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Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

NCT05111288

Recruiting

This study is being done to observe the effects of treatment from a device called the Bioboosti which utilizes pulsed electromagnetic waves on its ability to improve blood flow to the heart tissue in individuals with coronary artery disease (CAD).

Gender:

All

Ages:

18 years and above

Trial Updated:

05/15/2024

Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations

Conditions: Coronary Artery Disease, Myocardial Infarction

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health

NCT05819814

Recruiting

The goal of this randomized controlled trial is to assess the impact of disclosing a high polygenic risk result for coronary artery disease on change in cardiovascular health over one year.

Gender:

All

Ages:

Between 40 years and 75 years

Trial Updated:

05/08/2024

Locations: Massachusetts General Hospital, Boston, Massachusetts

Conditions: Coronary Artery Disease

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

NCT05850091

Recruiting

The goal of this double-blind randomized controlled trial is to determine how treatment with high intensity statin, low-dose colchicine, and their combination modulates progression and composition of coronary atherosclerosis in individuals with high polygenic risk for coronary artery disease.

Gender:

All

Ages:

Between 40 years and 75 years

Trial Updated:

05/08/2024

Locations: Massachusetts General Hospital, Boston, Massachusetts

Conditions: Coronary Artery Disease

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