Coronary Artery Disease Clinical Trials

A listing of 65 Coronary Artery Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 65 active clinical trials seeking participants for Coronary Artery Disease research studies. The states with the highest number of trials for Coronary Artery Disease participants are Florida, California, New York and Texas.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Heart Failure Clinical Trial

Recruiting

You or someone you love may be eligible for a heart failure clinical study. Eligible participants will receive study-related assessments, care, and treatment at no cost. You may be reimbursed for travel while participating. See if you are eligible.

Conditions:

Heart Failure

Congestive Heart Failure

Chronic Heart Failure

Heart Failure

Congestive

Learn More

Featured Offer

Lose Weight with GLP-1 Medications

Recruiting

Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.

GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.

As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.

Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD

NCT06713239

Recruiting

PARAMOUNT is a prospective randomized open-label trial testing the hypothesis that a personalized management strategy in symptomatic patients with suspicion of coronary artery disease (CAD), using a CT-based coronary atherosclerotic plaque assessment by AI-enabled quantitative software improves: certainty for diagnosis of CAD, control of CAD risk factors and efficiency of ICA referral with appropriate PCI compared to the usual care strategy based on current AHA/ACC guidelines for care of symptom... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/01/2025

Locations: Cardiology Associates of Mobile, Mobile, Alabama +13 locations

Conditions: Coronary Artery Disease

Learn More ›

Product Surveillance Registry

NCT01524276

Recruiting

The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.

Gender:

ALL

Ages:

All

Trial Updated:

06/26/2025

Locations: Not set, Birmingham, Alabama +380 locations

Not set, Birmingham, Alabama

Not set, Huntsville, Alabama

Not set, Chandler, Arizona

Not set, Phoenix, Arizona

Not set, Little Rock, Arkansas

Not set, Aliso Viejo, California

Not set, Chula Vista, California

Not set, Colton, California

Not set, La Jolla, California

Not set, Los Angeles, California

Not set, Napa, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Ventura, California

Not set, Aurora, Colorado

Not set, Colorado Springs, Colorado

Not set, Lakewood, Colorado

Not set, Darien, Connecticut

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Davie, Florida

Not set, Jacksonville, Florida

Not set, Naples, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Weston, Florida

Not set, Gainesville, Georgia

Not set, Chicago, Illinois

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, Iowa City, Iowa

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, New Orleans, Louisiana

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Boston, Massachusetts

Not set, Holyoke, Massachusetts

Not set, Ann Arbor, Michigan

Not set, Bay City, Michigan

Not set, Lansing, Michigan

Not set, Rochester Hills, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Jackson, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, St. Louis, Missouri

Not set, Omaha, Nebraska

Not set, Lebanon, New Hampshire

Not set, Camden, New Jersey

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, Ocean Township, New Jersey

Not set, Teaneck, New Jersey

Not set, Albuquerque, New Mexico

Not set, Albany, New York

Not set, Bay Shore, New York

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, Mount Kisco, New York

Not set, New Hyde Park, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Riverhead, New York

Not set, Roslyn, New York

Not set, Staten Island, New York

Not set, Stony Brook, New York

Not set, Utica, New York

Not set, Chapel Hill, North Carolina

Not set, Charleston, North Carolina

Not set, Durham, North Carolina

Not set, Pinehurst, North Carolina

Not set, Raleigh, North Carolina

Not set, Winston Salem, North Carolina

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Dayton, Ohio

Not set, Mount Orab, Ohio

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Mechanicsburg, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Charleston, South Carolina

Not set, Columbia, South Carolina

Not set, Orangeburg, South Carolina

Not set, Spartanburg, South Carolina

Not set, Sioux Falls, South Dakota

Not set, Germantown, Tennessee

Not set, Memphis, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Ft. Worth, Texas

Not set, Houston, Texas

Not set, Kyle, Texas

Not set, Plano, Texas

Not set, San Antonio, Texas

Not set, Tyler, Texas

Not set, Salt Lake City, Utah

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Fairfax, Virginia

Not set, Fredericksburg, Virginia

Not set, Bremerton, Washington

Not set, Seattle, Washington

Not set, Spokane, Washington

Not set, Morgantown, West Virginia

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Buenos Aires, Not set

Not set, Westmead, New South Wales

Not set, Chermside, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Aalst, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Genk, Not set

Not set, Gent, Not set

Not set, Leuven, Not set

Not set, Liege, Not set

Not set, Roeselare, Not set

Not set, Sint-Niklaas, Not set

Not set, São Paulo, Not set

Not set, Calgary, Alberta

Not set, Kingston, Ontario

Not set, Montreal, Quebec

Not set, Quebec City, Not set

Not set, Quebec, Not set

Not set, Toronto, Not set

Not set, Chengdu, Sichuan

Not set, Beijing, Not set

Not set, Chengdu, Not set

Not set, Dalian, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Suzhou, Not set

Not set, Medellin, Not set

Not set, Pereira, Not set

Not set, Rionegro, Not set

Not set, Praha, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Kobenhavn, Not set

Not set, Odense, Not set

Not set, Helsinki, Not set

Not set, Tampere, Not set

Not set, Avignon, Not set

Not set, Bordeaux, Not set

Not set, Boulogne-Billancourt, Not set

Not set, Brest Cedex, Not set

Not set, Caen, Not set

Not set, Chambray, Not set

Not set, Clermont Ferrand, Not set

Not set, Créteil, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille Cedex, Not set

Not set, Marseille Cedex 5, Not set

Not set, Montpellier Cedex 5, Not set

Not set, Nantes, Not set

Not set, Ollioules, Not set

Not set, Paris, Not set

Not set, Pessac, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Toulouse Cedex 9, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Arnsberg, Not set

Not set, Bad Oeynhausen, Not set

Not set, Berlin, Not set

Not set, Bochum, Not set

Not set, Bremen, Not set

Not set, Düsseldorf, Not set

Not set, Freiburg, Not set

Not set, Hagen, Not set

Not set, Halle (Saale), Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Heidelberg, Not set

Not set, Jena, Not set

Not set, Karlsruhe, Not set

Not set, Köln, Not set

Not set, Leipzig, Not set

Not set, Lübeck, Not set

Not set, Munster, Not set

Not set, München, Not set

Not set, Stuttgart, Not set

Not set, Tubingen, Not set

Not set, Ulm, Not set

Not set, Wiesbaden, Not set

Not set, Athens, Not set

Not set, Maroúsi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Hyderabad, Telangana

Not set, Bangalore, Not set

Not set, Bengaluru, Not set

Not set, Chennai, Not set

Not set, Gurugram, Not set

Not set, New Delhi, Not set

Not set, Galway, Not set

Not set, Ashkelon, Not set

Not set, Be'er Sheva, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Acquaviva Delle Fonti, Not set

Not set, Ancona, Not set

Not set, Bari, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Caserta, Not set

Not set, Castrovillari, Not set

Not set, Cotignola, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Modena, Not set

Not set, Monza, Not set

Not set, Palermo, Not set

Not set, Pisa, Not set

Not set, Roma, Not set

Not set, Rome, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Sakai, Osaka

Not set, Ageo, Saitama

Not set, Hidaka, Saitama

Not set, Koshigaya, Saitama

Not set, Tokyo, Tachikawa

Not set, Bunkyō-Ku, Tokyo

Not set, Minato-Ku, Tokyo

Not set, Yonago, Tottori

Not set, Chiba, Not set

Not set, Fukui, Not set

Not set, Fukuoka, Not set

Not set, Gifu, Not set

Not set, Hirosaki, Not set

Not set, Hiroshima City, Not set

Not set, Hiroshima, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Kofu, Not set

Not set, Kumamoto, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Tokyo, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Yangsan, Gyeongsangnam-do

Not set, Busan, Not set

Not set, Changwon, Not set

Not set, Cheongju-si, Not set

Not set, Daegu, Not set

Not set, Daejeon, Not set

Not set, Gangneung, Not set

Not set, Gwangju, Not set

Not set, Gyeonggi-do, Not set

Not set, Incheon, Not set

Not set, Jeonju, Not set

Not set, Seongnam-si, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Ciudad de mexico, Not set

Not set, Den Haag, Not set

Not set, Doetinchem, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Heerlen, Not set

Not set, Hengelo, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Lorenskog, Not set

Not set, Trondheim, Not set

Not set, Panama, Not set

Not set, Poznań, Not set

Not set, Warszawa, Not set

Not set, Zabrze, Not set

Not set, Carnaxide, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Aibonito, Not set

Not set, Rio Piedras, Not set

Not set, Jeddah, Not set

Not set, Riyadh, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, L'Hospitalet De Llobregat, Not set

Not set, Madrid, Not set

Not set, Málaga, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago De Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Vitoria-Gasteiz, Not set

Not set, Skövde, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneve, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Morges, Not set

Not set, Zürich, Not set

Not set, Taichung, Not set

Not set, Barnstaple, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Chelmsford, Not set

Not set, Glasgow, Not set

Not set, Harrow, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Newcastle Upon Tyne, Not set

Not set, Northampton, Not set

Not set, Sheffield, Not set

Not set, Southampton, Not set

Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency, Neurovascular, Coronary Artery Disease, Ear, Nose and Throat Disorder

Learn More ›

An Investigational Trial to Evaluate the Effects of the Drug XC001 Delivered Via an Endocardial Delivery Catheter in Subjects With Chronic Angina Caused by Coronary Artery Disease

NCT07048808

Recruiting

This is a two-part study, comprised of an initial open-label run-in phase (Part 1) in a subset of 3 subjects to provide first data regarding safety, and feasibility of the percutaneous endovascular catheter-facilitated intramyocardial delivery of XC001 in patients with RA due to obstructive CAD. Part 1 of the study is comprised of 3 subjects with RA (CCS class II-IV) who will receive 4×1011 viral particles (vp) XC001. An Independent Data Monitoring Committee (IDMC), the committee will review sa... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

06/24/2025

Locations: Christ Hospital, Cincinnati, Ohio

Conditions: Refractory Angina, Coronary Artery Disease

Learn More ›

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

NCT05427370

Recruiting

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether C... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/17/2025

Locations: Cedars-Sinai, Los Angeles, California +34 locations

Cedars-Sinai, Los Angeles, California

UofL Health, Inc, Louisville, Kentucky

Mayo Clinic, Rochester, Minnesota

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Medical University of Vienna, Vienna, Not set

Heart Institute, Medical School of the University of Sao Paulo_INCOR, São Paulo, Not set

University of Calgary; Libin Cardiovascular Institute, Calgary, Alberta

Mackenzie Health Sciences Center, Edmonton, Alberta

Fraser Health; Royal Columbian Hospital, New Westminster, British Columbia

Providence Health, Vancouver, British Columbia

Queen Elizabeth II Hospital, Halifax, Nova Scotia

Hamilton General Hospital, Hamilton, Ontario

London Health Sciences Center, University Hospital, London, Ontario

Southlake Regional HC, Newmarket, Ontario

Ottawa Heart Institute, Ottawa, Ontario

Sunnybrook Health Sciences Center, Toronto, Ontario

St. Michael's, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Center Hospitalier Universitaire de Montreal, Montréal, Quebec

Montreal Heart Institute, Montréal, Quebec

Hospital Sacre-Coeur, Montréal, Quebec

Institut de Cardiologie Quebec (QC) - Laval, Québec, Quebec

Jilin Heart Hospital, Jilin, Changchun

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Not set

Clinical Hospital Dubrava, Sušak, Zagreb

University Hospital Dusseldorf, Düsseldorf, Not set

G Kuppuswamy Naidu Memorial Hospital (GKNM), Palayam, Tamil Nadu

European Hospital, Via Portuense, Roma, RM

Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Not set

Medical University of Silesia, Katowice, Not set

Unidade Local de Saude Lisboa Ocidental (ULSLO), Lisboa, Not set

Dedinje Cardiovascular Institute, Belgrade, Not set

Hospital Clinic de Barcelona (ICCV), Barcelona, L'Eixample

Hospital del Vinalopó, Alicante, Not set

Hospital Universitario de Navarra, Pamplona, Not set

Conditions: Coronary Artery Disease, Heart Failure Systolic

Learn More ›

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

NCT05701358

Recruiting

COMPLETE-2 is a prospective, multi-centre, randomized controlled trial comparing a strategy of physiology-guided complete revascularization to angiography-guided complete revascularization in patients with acute ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel coronary artery disease (CAD) who have undergone successful culprit lesion Percutaneous Coronary Intervention (PCI). COMPLETE-2 OCT is a large scale, prospective... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: UCLA, Los Angeles, California +112 locations

UCLA, Los Angeles, California

University of California, San Francisco, San Francisco, California

Cardiovascular Research Institute of Kansas, Wichita, Kansas

The Johns Hopkins University School of Medicine, Baltimore, Maryland

University of Michigan, Ann Arbor, Michigan

Metropolitan Cardiology Consultants / Metropolitan Heart and Vascular Institute (MCC/MHVI), Coon Rapids, Minnesota

RWJ Barnabas Health, Jersey City, New Jersey

Montefiore Medical Center, Bronx, New York

Bassett Medical Center, Cooperstown, New York

VA New York Harbor HealthCare System, New York, New York

NYU Grossman School of Medicine, New York, New York

Cleveland Clinic, Cleveland, Ohio

University of Virginia Medical Center, Charlottesville, Virginia

Westmead Hospital, Westmead, New South Wales

Klinik Floridsdorf, Vienna, Not set

McGill University Health Centre (MUHC), Montréal, Quebec

William Osler Health System, Brampton, Not set

University of Alberta Hospital, Mazankowski Heart, Edmonton, Not set

Hamilton Health Sciences, Hamilton, Not set

Kingston Health Sciences Centre, Kingston, Not set

St. Mary's General Hospital, Kitchener, Not set

London Health Sciences Centre, London, Not set

Centre Hospitalier de l'Universite de Montreal, Montréal, Not set

Hopital du Sacre-Coeur de Montreal, Montréal, Not set

Southlake Regional Health Centre, Newmarket, Not set

Nova Scotia Health, Nova Scotia, Not set

University of Ottawa Heart Institute, Ottawa, Not set

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Not set

Regina General Hospital, Regina, Not set

Royal University Hospital, Saskatoon, Not set

Niagara Health, St. Catharines, Not set

Newfoundland and Labrador Health Services, St. John's, Not set

Thunder Bay Regional Health Sciences Centre, Thunder Bay, Not set

St. Michael's Hospital (Unity Health Toronto), Toronto, Not set

Sunnybrook Health Sciences Centre, Toronto, Not set

Ciusss McQ - Chaur, Trois-Rivières, Not set

St Paul's Hospital, Vancouver, Not set

Vancouver General Hospital, Vancouver, Not set

St. Boniface Hospital, Winnipeg, Not set

St. Anne's University Hospital, Brno, Not set

Aalborg University Hospital, Aalborg, Not set

Aarhus University Hospital, Aarhus, Not set

Rigshospitalet - Copenhagen University Hospital, Copenhagen, Not set

Helsinki University Hospital, Helsinki, Not set

TAYS Sydankeskus Oy, Tampere, Not set

Turku University Hospital, Turku, Not set

St. Vinzenz-Hospital, Cologne, Not set

Helios Amper-Klinikum, Dachau, Not set

Universitatsklinikum Frankfurt, Frankfurt, Not set

Marienkrankenhaus, Hamburg, Not set

Schoen Klink Hamburg, Hamburg, Not set

University Heart & Vascular Center Hamburg, Hamburg, Not set

WKK Heide, Heide, Not set

Gottsegen National Cardiovascular Center, Budapest, Not set

University of Szeged, Szeged, Not set

Lisie Hospital, Ernakulam, Kerala

Meditrina Hospital, Kollam, Kerala

Caritas Hospital Trust, Kottayam, Kerala

Apollo Rajshree Hospitals, Indore, Madhya Pradesh

Rukmani Birla Hospital, Jaipur, Rajasthan

Apollo Hospital, Chennai, Tamil Nadu

The Madras Medical Mission, Chennai, Tamil Nadu

Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu

Medicover Hospitals, Hyderabad, Not set

Krishna Institute of Medical Sciences, Secunderabad, Not set

Azienda USL Toscana Sud Est, Arezzo, Not set

UOC Cardiologia - Ospedale Maggiore, Bologna, Not set

Azienda Ospedaliero - Universitaria di Ferrara, Ferrara, Not set

Misericordia Hospital, Grosseto, Not set

Azienda USL-IRCCS di Reggio Emilia, Reggio, Reggio Emilia, Not set

Sant Andrea Hospital - Sapienza University, Rome, Not set

Sorlandet Hospital Arendal, Kristiansand, Arendal

Oslo University Hospital Ulleval, Oslo, Not set

Stavanger University Hospital, Stavanger, Not set

University Hospital Tromso, Tromso, Not set

Provincial Specialized Hospital, Legnica, Dolnoslaskie

Miedziowym Centrum Zdrowia S.A. w Lubinie, Lubin, Dolnoslaskie

Medical University of Warsaw, Warsaw, Mazowieckie

Institute for Cardiovascular Diseases Dedinje, Belgrade, Not set

University Clinical Center of Serbia, Belgrade, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Ramon y Cajal, Madrid, Not set

Hospital Universitario de La Princesa, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Virgen del Rocio, Seville, Not set

Hospital Universitari i Politecnic La Fe, Valencia, Not set

Hospital Clinico Universitario de Valladolid, Valladolid, Not set

Karolinska University Hospital, Huddinge, Not set

Lanssjukhuset RYHOV, Jonkoping,, Not set

Karlstad Central Hospital, Karlstad, Not set

Skane University Hospital, Lund, Not set

Danderyd Hospital, Stockholm, Not set

Umeå University Hospital, Umeå, Not set

Uppsala University Hospital, Uppsala, Not set

East Kent Hospitals University NHS Foundation Trust, Ashford, Not set

Blackpool Teaching Hospitals, Blackpool, Not set

Ninewells Hospital, Dundee, Not set

Harefield Hospital, Harefield, Not set

Kettering General Hospital, Kettering, Not set

University Hospitals of Leicester, Leicester, Not set

Liverpool Heart and Chest Hospital, Liverpool, Not set

Barts Health NHS Trust, London, Not set

Imperial College Healthcare NHS Trust, London, Not set

Royal Free London NHS Foundation Trust, London, Not set

Manchester University NHS Foundation Trust, Manchester, Not set

The James Cook University Hospital, Middlesbrough, Not set

Freeman Hospital, Newcastle upon Tyne, Not set

Royal Berkshire Foundation NHS Trust, Reading, Not set

Sheffield Teaching Hospitals, Sheffield, Not set

East and North Hertfordshire NHS Trust, Stevenage, Not set

Royal Cornwall Hospitals NHS Trust, Truro, Not set

The Royal Wolverhampton NHS Trust, Wolverhampton, Not set

Worcestershire Acute Hospitals NHS Trust, Worcester, Not set

Conditions: Acute Myocardial Infarction, Coronary Artery Disease

Learn More ›

Abbott's Coronary IVL IDE Study

NCT06885177

Recruiting

A prospective, single-arm, multi-center Coronary IVL IDE Study with 47 US sites

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/16/2025

Locations: Arkansas Heart Hospital, Little Rock, Arkansas +9 locations

Conditions: Coronary Artery Calcification, Coronary Artery Disease, Stenotic Coronary Lesion

Learn More ›

A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque

NCT06305559

Recruiting

This placebo-controlled, double-blind, randomized, Phase 3 study is being conducted in adult participants with high-risk atherosclerotic cardiovascular disease (ASCVD) who are not adequately controlled by their maximally tolerated lipid-modifying therapy, to assess the impact of the obicetrapib 10 mg + ezetimibe 10 mg FDC daily on coronary plaque and inflammation characteristics, evaluated using cardiovascular computed tomography angiography (CCTA).

Gender:

ALL

Ages:

45 years and above

Trial Updated:

06/12/2025

Locations: NGMR, Hialeah, Florida

Conditions: Lipidemia, Coronary Artery Disease, Plaque, Atherosclerotic

Learn More ›

CTSN Embolic Protection Trial

NCT06027788

Recruiting

This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

Gender:

ALL

Ages:

60 years and above

Trial Updated:

06/09/2025

Locations: CHI St. Vincent Heart Institute, North Little Rock, Arkansas +27 locations

CHI St. Vincent Heart Institute, North Little Rock, Arkansas

Keck Hospital of the University of Southern California, Los Angeles, California

Emory University, Atlanta, Georgia

Indiana University, Bloomington, Indiana

Indiana Ohio Heart, Fort Wayne, Indiana

Ochsner Clinic, New Orleans, Louisiana

Maine Medical Center, Portland, Maine

Johns Hopkins Medicine, Baltimore, Maryland

University of Maryland, College Park, Maryland

Massachusetts General Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Mayo Clinic, Rochester, Minnesota

Saint Luke's Hospital of Kansas City, Kansas City, Missouri

Montefiore Medical Center, Bronx, New York

Columbia University Medical Center, New York, New York

New York Presbyterian-Cornell Medical Center, New York, New York

NYU Langone Hospital Brooklyn, New York, New York

Northwell Health, New York, New York

Duke University, Durham, North Carolina

University Hospitals, Cleveland, Ohio

Cleveland Clinic, Cleveland, Ohio

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

University of Virginia, Charlottesville, Virginia

West Virginia University, Morgantown, West Virginia

London Health Sciences Centre, London, Ontario

University of Ottawa Heart Institute, Ottawa, Ontario

Montreal Heart Institute, Montréal, Quebec

Hôpital Laval, Quebec City, Quebec

Conditions: Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease

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Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

NCT06181240

Recruiting

The FRACTURE Trial is a prospective, non-randomized, single-arm, multicenter, interventional study in US and international centers.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/07/2025

Locations: Scripps Health, La Jolla, California +29 locations

Scripps Health, La Jolla, California

Riverside Community Hospital, Riverside, California

The Cardiac & Vascular Institute, Gainesville, Florida

HCA FL Memorial Hospital, Jacksonville, Florida

HCA Florida Largo Hospital, Largo, Florida

Northeast Georgia Medical Center, Gainesville, Georgia

Brigham and Women's Hospital, Boston, Massachusetts

Massachusetts General Hospital, Boston, Massachusetts

Trinity Health Michigan Heart, Ypsilanti, Michigan

North Mississippi Medical Center, Tupelo, Mississippi

The Icahn School of Medicine at Mt. Sinai, New York, New York

Nyph/Cuimc, New York, New York

Tristar Centennial Medical Center, Nashville, Tennessee

Methodist Healthcare Methodist Research Institute, San Antonio, Texas

Chippenham Johnson Willis Hospital, Richmond, Virginia

Onze-Lieve-Vrouwziekenhuis, afgekort OLV ziekenhuis, Aalst, Not set

Aarhus University Hospital, Aarhus, Not set

Segeberger Kliniken GmbH,, Bad Segeberg, Not set

SJG St. Paulus GmbH, St.-Johannes-Hospital Dortmund, Dortmund, Not set

Cellitinnen Krankenhaus St. Vinzenz, Köln, Not set

Klaipeda University Hospital, Klaipėda, Not set

Vilnius University Hospital Santaros Klinikos, Vilnius, Not set

Amsterdam University Medical Center, Amsterdam, Not set

Erasmus Medical Center, Rotterdam, Not set

Harefield Hospital, Harefield, Not set

Royal Free Hospital, London, Not set

St. Thomas' Hospital, London, Not set

King's College Hospital, London, Not set

St George's University of London, London, Not set

Royal Brompton Hospital, London, Not set

Conditions: Coronary Artery Disease, Coronary Artery Calcification

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

NCT06445608

Recruiting

This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure.

Gender:

ALL

Ages:

Between 18 years and 90 years

Trial Updated:

06/06/2025

Locations: Dignity Health - Chandler Regional Medical Center, Chandler, Arizona +17 locations

Conditions: Coronary Artery Disease

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Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease

NCT04272060

Recruiting

Cardiac catheterization with invasive coronary angiography is the gold standard for determining the presence or absence of significant coronary heart disease (CHD). However, cardiac catheterization is costly and, as an invasive procedure, it is associated with some risk of adverse events, rarely even stroke, myocardial infarction, or death. Recent advances in multi-detector computed tomography angiography (CTA) have allowed rapid, noninvasive coronary artery imaging in patients with suspected CHD. CTA generally yields high accuracy for identifying patients with CHD when compared to cardiac catheterization. However, diagnostic accuracy is reduced in the setting of severe coronary artery calcification and coronary stents due to its inferior spatial resolution compared to cardiac catheterization. Because high-risk patients often have severe coronary calcification or stents, the application of CTA has been particularly limited in this important patient group. Recently, an ultrahigh-resolution CT scanner was released which has shown promise to overcome the limitation of conventional CTA in the setting of severe coronary artery calcification or stents. This ultrahigh-resolution "precision" CT scanner (UHR-CT) contains detector rows with half the width than currently available systems (0.25 mm vs. 0.5 mm) resulting in approximately twice the spatial resolution. The purpose of this investigation is to test the hypothesis that high-resolution CTA is not inferior to the current standard of cardiac catheterization for identifying significant CHD in patients with high-risk characteristics, including severe coronary artery calcification and coronary stents. The investigators propose to enroll 50 patients over 24-30 months in this investigation as part of a multicenter study. Patients referred for cardiac catheterization with known CHD and suspected obstructive coronary artery stenosis will be included. All patients will undergo both cardiac catheterization and UHR-CT for determining significant CHD as defined by coronary functional assessment. The primary end point will be the diagnostic accuracy by area-under-curve (AUC) method for identifying patients with hemodynamically significant CHD. Read Less

Gender:

ALL

Ages:

Between 45 years and 85 years

Trial Updated:

06/05/2025

Locations: Johns Hopkins Hospital, Baltimore, Maryland

Conditions: Coronary Artery Disease

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Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure

NCT07016477

Recruiting

The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple comorbidities, high prevalence of heavily calcified coronary artery disease (CAD) and revascularized coronary arteries. Such vulnerable patients could benefit from a more precise assessment and charact... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/04/2025

Locations: Medical University of South Carolina, Charleston, South Carolina +6 locations

Conditions: Coronary Artery Disease, Aortic Valve Stenosis, Tomography, X-Ray Computed

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