Heart Failure Clinical Trials

A listing of 179 Heart Failure clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 179 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and Pennsylvania.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

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Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

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Featured Trial

Heart Failure Clinical Trial

Recruiting

You or someone you love may be eligible for a heart failure clinical study. Eligible participants will receive study-related assessments, care, and treatment at no cost. You may be reimbursed for travel while participating. See if you are eligible.

Conditions:

Heart Failure

Congestive Heart Failure

Chronic Heart Failure

Heart Failure

Congestive

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Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68)

NCT04363697

Recruiting

This is an international, multicenter, parallel-group, randomized, double-blind, placebo-controlled trial in patients who have been stabilized during hospitalization for acute heart failure, evaluating the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/15/2025

Locations: TIMI Study Group, Boston, Massachusetts

Conditions: Acute Heart Failure, Heart Failure

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Mechanisms of Diuretic Resistance in Heart Failure, Aim 1

NCT05323487

Recruiting

This study will employ a randomized order, double-blind, repeated measures dose ranging design. This design was chosen in order to generate multiple within-subject serial loop diuretic dose response exposures. The overall study schema will include 75 heart failure (HF) patients.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/10/2025

Locations: Yale University, New Haven, Connecticut

Conditions: Heart Failure

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Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure

NCT05177822

Recruiting

Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.

Gender:

ALL

Ages:

21 years and above

Trial Updated:

01/10/2025

Locations: University of Virginia, Charlottesville, Virginia +1 locations

Conditions: Heart Failure

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Polypill Strategy for Heart Failure With Reduced Ejection Fraction

NCT04633005

Recruiting

Heart failure with a reduced ejection fraction (HFrEF) represents a significant public health burden in the United States, with a growing prevalence particularly among African Americans and Hispanic Americans and individuals of low socioeconomic status (SES). Although effective therapies exist, gaps in their uptake contribute substantially to the excess burden of heart failure. The "polypill" is an inexpensive once daily pill containing three agents proven to improve morbidity and mortality in h... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/03/2025

Locations: UT Southwestern Medical Center, Dallas, Texas

Conditions: Heart Failure

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Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

NCT04982419

Recruiting

This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/27/2024

Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania +2 locations

Conditions: Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography, Percutaneous Coronary Intervention

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Early Feasibility Study of the NORM™ System in Heart Failure Patients (FUTURE-HFII)

NCT05763407

Recruiting

Early Feasibility Study of the NORM™ System in Heart Failure Patients

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/23/2024

Locations: Columbia University Irving Medical Center/ New York Presbyterian Hospital, New York, New York +4 locations

Conditions: Heart Failure

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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

NCT00271180

Recruiting

The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.

Gender:

ALL

Ages:

All

Trial Updated:

12/23/2024

Locations: Not set, Birmingham, Alabama +308 locations

Not set, Birmingham, Alabama

Not set, Anchorage, Alaska

Not set, Chandler, Arizona

Not set, Jonesboro, Arkansas

Not set, Little Rock, Arkansas

Not set, Bakersfield, California

Not set, Chula Vista, California

Not set, La Jolla, California

Not set, Los Angeles, California

Not set, Palm Springs, California

Not set, Rancho Mirage, California

Not set, Redwood City, California

Not set, Salinas, California

Not set, San Diego, California

Not set, Stanford, California

Not set, Torrance, California

Not set, Van Nuys, California

Not set, Ventura, California

Not set, Centennial, Colorado

Not set, Colorado Springs, Colorado

Not set, Denver, Colorado

Not set, Lakewood, Colorado

Not set, Hartford, Connecticut

Not set, New Haven, Connecticut

Not set, Washington, District of Columbia

Not set, Bradenton, Florida

Not set, Clearwater, Florida

Not set, Hollywood, Florida

Not set, Jacksonville, Florida

Not set, Panama City, Florida

Not set, Safety Harbor, Florida

Not set, Sarasota, Florida

Not set, Atlanta, Georgia

Not set, Marietta, Georgia

Not set, Evansville, Indiana

Not set, Indianapolis, Indiana

Not set, West Des Moines, Iowa

Not set, Kansas City, Kansas

Not set, Edgewood, Kentucky

Not set, Louisville, Kentucky

Not set, Baton Rouge, Louisiana

Not set, Shreveport, Louisiana

Not set, Baltimore, Maryland

Not set, Bethesda, Maryland

Not set, Clinton, Maryland

Not set, Hyattsville, Maryland

Not set, Salisbury, Maryland

Not set, Silver Spring, Maryland

Not set, Takoma Park, Maryland

Not set, Boston, Massachusetts

Not set, Lansing, Michigan

Not set, Marquette, Michigan

Not set, Ypsilanti, Michigan

Not set, Coon Rapids, Minnesota

Not set, Minneapolis, Minnesota

Not set, Robbinsdale, Minnesota

Not set, Rochester, Minnesota

Not set, Saint Cloud, Minnesota

Not set, Saint Paul, Minnesota

Not set, Hattiesburg, Mississippi

Not set, Columbia, Missouri

Not set, Kansas City, Missouri

Not set, Saint Louis, Missouri

Not set, Omaha, Nebraska

Not set, Marlton, New Jersey

Not set, Morristown, New Jersey

Not set, New Brunswick, New Jersey

Not set, Ocean City, New Jersey

Not set, Ridgewood, New Jersey

Not set, Albuquerque, New Mexico

Not set, Huntington, New York

Not set, Manhasset, New York

Not set, New York, New York

Not set, Poughkeepsie, New York

Not set, Utica, New York

Not set, Durham, North Carolina

Not set, Raleigh, North Carolina

Not set, Akron, Ohio

Not set, Cincinnati, Ohio

Not set, Cleveland, Ohio

Not set, Columbus, Ohio

Not set, Toledo, Ohio

Not set, Oklahoma City, Oklahoma

Not set, Portland, Oregon

Not set, Allentown, Pennsylvania

Not set, Bethlehem, Pennsylvania

Not set, Danville, Pennsylvania

Not set, Erie, Pennsylvania

Not set, Lancaster, Pennsylvania

Not set, Philadelphia, Pennsylvania

Not set, Pittsburgh, Pennsylvania

Not set, Wilkes-Barre, Pennsylvania

Not set, Columbia, South Carolina

Not set, Germantown, Tennessee

Not set, Nashville, Tennessee

Not set, Austin, Texas

Not set, Dallas, Texas

Not set, Fort Worth, Texas

Not set, Houston, Texas

Not set, Plano, Texas

Not set, The Woodlands, Texas

Not set, Tyler, Texas

Not set, Burlington, Vermont

Not set, Charlottesville, Virginia

Not set, Olympia, Washington

Not set, Spokane, Washington

Not set, Madison, Wisconsin

Not set, Milwaukee, Wisconsin

Not set, Chermside, Not set

Not set, Douglas, Not set

Not set, Murdoch, Not set

Not set, Southport, Not set

Not set, Graz, Not set

Not set, Innsbruck, Not set

Not set, Linz, Not set

Not set, Wien, Not set

Not set, Brugge, Not set

Not set, Brussel, Not set

Not set, Edegem, Not set

Not set, Leuven, Not set

Not set, Liège, Not set

Not set, Yvoir, Not set

Not set, Calgary, Not set

Not set, Kingston, Not set

Not set, Montreal, Not set

Not set, Québec, Not set

Not set, Beijing, Not set

Not set, Changsha, Not set

Not set, Dalian, Not set

Not set, Fuzhou, Not set

Not set, Guangzhou, Not set

Not set, Hangzhou, Not set

Not set, Harbin, Not set

Not set, Kunming, Not set

Not set, Nanchang, Not set

Not set, Shanghai, Not set

Not set, Shantou, Not set

Not set, Suzhou, Not set

Not set, Taiyuan, Not set

Not set, Tianjin, Not set

Not set, Praha, Not set

Not set, Copenhagen, Not set

Not set, Hellerup, Not set

Not set, Hillerød, Not set

Not set, Odense, Not set

Not set, Århus, Not set

Not set, Helsinki, Not set

Not set, Avignon, Not set

Not set, Bayonne, Not set

Not set, Brest, Not set

Not set, Caen, Not set

Not set, Chambray-lès-Tours, Not set

Not set, Clermont-Ferrand, Not set

Not set, Dijon, Not set

Not set, La Rochelle, Not set

Not set, La Tronche, Not set

Not set, Lille, Not set

Not set, Montpellier, Not set

Not set, Nantes, Not set

Not set, Neuilly-sur-Seine, Not set

Not set, Paris, Not set

Not set, Pessac, Not set

Not set, Pringy, Not set

Not set, Rennes, Not set

Not set, Saint-Priest-en-Jarez, Not set

Not set, Strasbourg, Not set

Not set, Toulouse, Not set

Not set, Vandoeuvre les Nancy, Not set

Not set, Villeurbanne, Not set

Not set, Aachen, Not set

Not set, Bad Oeynhausen, Not set

Not set, Bremen, Not set

Not set, Dresden, Not set

Not set, Düsseldorf, Not set

Not set, Essen, Not set

Not set, Hamburg, Not set

Not set, Hannover, Not set

Not set, Heidelberg, Not set

Not set, Homburg, Not set

Not set, Jena, Not set

Not set, Köln, Not set

Not set, München, Not set

Not set, Münster, Not set

Not set, Tübingen, Not set

Not set, Ulm, Not set

Not set, Athens, Not set

Not set, Marousi, Not set

Not set, Thessaloníki, Not set

Not set, Hong Kong, Not set

Not set, Budapest, Not set

Not set, Reykjavik, Not set

Not set, Bangalore, Not set

Not set, Gurgaon, Not set

Not set, New Delhi, Not set

Not set, Ashkelon, Not set

Not set, Be'er Sheva, Not set

Not set, Jerusalem, Not set

Not set, Ramat Gan, Not set

Not set, Ancona, Not set

Not set, Bari, Not set

Not set, Bologna, Not set

Not set, Brescia, Not set

Not set, Castrovillari, Not set

Not set, Cotignola, Not set

Not set, Lecce, Not set

Not set, Milano, Not set

Not set, Monza, Not set

Not set, Pisa, Not set

Not set, Taranto, Not set

Not set, Udine, Not set

Not set, Ageo, Not set

Not set, Gifu, Not set

Not set, Hidaka, Not set

Not set, Hiroshima City, Not set

Not set, Kagoshima, Not set

Not set, Kamakura, Not set

Not set, Kawasaki, Not set

Not set, Kitakyushu, Not set

Not set, Koshigaya, Not set

Not set, Kyoto, Not set

Not set, Mitaka, Not set

Not set, Nagoya, Not set

Not set, Niigata, Not set

Not set, Okayama, Not set

Not set, Sapporo, Not set

Not set, Shinagawa-Ku, Not set

Not set, Shizuoka, Not set

Not set, Suita, Not set

Not set, Tokyo, Not set

Not set, Toyoake, Not set

Not set, Urasoe, Not set

Not set, Yamagata, Not set

Not set, Yokohama, Not set

Not set, Ōsaka-sayama, Not set

Not set, Cheongju-si, Not set

Not set, Daejeon, Not set

Not set, Gyeonggi-do, Not set

Not set, Seoul, Not set

Not set, Suwon-si, Not set

Not set, Hadiya, Not set

Not set, Kuwait, Not set

Not set, Kuala Lumpur, Not set

Not set, Amsterdam, Not set

Not set, Breda, Not set

Not set, Den Haag, Not set

Not set, Eindhoven, Not set

Not set, Enschede, Not set

Not set, Groningen, Not set

Not set, Leiden, Not set

Not set, Maastricht, Not set

Not set, Nieuwegein, Not set

Not set, Rotterdam, Not set

Not set, Christchurch, Not set

Not set, Bergen, Not set

Not set, Oslo, Not set

Not set, Trondheim, Not set

Not set, Poznań, Not set

Not set, Warsaw, Not set

Not set, Zabrze, Not set

Not set, Carnaxide, Not set

Not set, Creixomil, Not set

Not set, Lisboa, Not set

Not set, Porto, Not set

Not set, Santarém, Not set

Not set, Jeddah, Not set

Not set, Riyadh, Not set

Not set, Belgrade, Not set

Not set, Bratislava, Not set

Not set, Košice, Not set

Not set, Ljubljana, Not set

Not set, A Coruña, Not set

Not set, Barcelona, Not set

Not set, Córdoba, Not set

Not set, Girona, Not set

Not set, Granada, Not set

Not set, Madrid, Not set

Not set, Palma De Mallorca, Not set

Not set, Salamanca, Not set

Not set, Santa Cruz De Tenerife, Not set

Not set, Santiago de Compostela, Not set

Not set, Toledo, Not set

Not set, Valencia, Not set

Not set, Valladolid, Not set

Not set, Vitoria-Gasteiz, Not set

Not set, Göteborg, Not set

Not set, Lund, Not set

Not set, Skövde, Not set

Not set, Uppsala, Not set

Not set, Basel, Not set

Not set, Bern, Not set

Not set, Fribourg, Not set

Not set, Geneva, Not set

Not set, Lausanne, Not set

Not set, Lugano, Not set

Not set, Zürich, Not set

Not set, Birmingham, Not set

Not set, Blackpool, Not set

Not set, Bristol, Not set

Not set, Leeds, Not set

Not set, Leicester, Not set

Not set, Liverpool, Not set

Not set, London, Not set

Not set, Manchester, Not set

Not set, Middlesbrough, Not set

Not set, Northampton, Not set

Not set, Nottingham, Not set

Not set, Sheffield, Not set

Not set, Southampton, Not set

Conditions: Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia

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Effects of Acute and Chronic Empagliflozin Heart Failure

NCT05553938

Recruiting

This is a 60-patient randomized, double-blind, placebo-controlled mechanistic study to understand the utility of empagliflozin in worsening heart failure (HF) patients with or without diabetes. Participants will be randomized to empagliflozin or placebo for 6 weeks, followed by a crossover of placebo patients to active therapy at 6 weeks-12 weeks.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/16/2024

Locations: Yale New Haven Hospital, New Haven, Connecticut +1 locations

Conditions: Heart Failure

Learn More ›

Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

NCT05537467

Recruiting

The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/13/2024

Locations: University of Kentucky, Lexington, Kentucky

Conditions: Heart Failure

Learn More ›

A SkeleTal Muscle Recovery Intervention with Dietary Protein in Heart Failure

NCT05627440

Recruiting

Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF). This prospective randomized controlled trial will compare changes in the muscle mass in the arms and the legs (appendicular lean mass) in patients with HFrEF randomized between 3 groups of no, low- or high-dose protein supplementation. The dietary protein supplementation will be Ensure(R) products manufactured by Abbott Nutrition. The Investigators hypothe... Read More

Gender:

ALL

Ages:

Between 18 years and 100 years

Trial Updated:

12/12/2024

Locations: Tufts Medical Center, Boston, Massachusetts +1 locations

Conditions: Heart Failure, Muscle Atrophy

Learn More ›

Brain Volume and Cardiac Function in Heart Failure

NCT06623344

Recruiting

Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes. Indeed, lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke, dementia, or heart failure. A few... Read More

Gender:

ALL

Ages:

21 years and above

Trial Updated:

12/10/2024

Locations: Johns Hopkins Center for Advanced Imaging and Research Science, Johns Hopkins Science + Technology Park at 1812 Ashland Avenue, Baltimore, MD, Baltimore, Maryland +1 locations

Conditions: Heart Failure

Learn More ›

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

NCT05577819

Recruiting

Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF) or diastolic heart failure. In this single center diagnostic study, we will evaluate for ATTR in patients with HFpEF in order to to determine how frequently this occurs and how we can predict which heart failure patients may have TTR amyloidosis. Our goal is to identify a... Read More

Gender:

ALL

Ages:

65 years and above

Trial Updated:

12/06/2024

Locations: Massachusetts General Hospital, Boston, Massachusetts

Conditions: Transthyretin Amyloidosis, Heart Failure, Heart Failure, Diastolic, Amyloidosis

Learn More ›