District Of Columbia is currently home to 851 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic
NCT06623981
Recruiting
The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children aged 4-11 years in an urban pediatric asthma clinic. Researchers will compare Enhanced IPT-B and supplemented usual care (brief care coordination). The main questions the trial aims to answer are: 1. Does Enhanced IPT-B decrease maternal depressive symptoms? 2. Does Enhanced IPT-B... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
10/21/2024
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Asthma in Children, Depression
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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
10/21/2024
Locations: MedStar Cardiovascular Research Network, Washington, District of Columbia
Conditions: Heart Failure With Preserved Ejection Fraction
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Optimal Pacing Rate for Cardiac Resynchronization Therapy
NCT06445439
Recruiting
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test. The investigators will randomly assign half of the participants to a starting rate of 60 bpm and then switch them to a rate of 80 bpm for 3 months, and vice versa.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/09/2024
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia
Conditions: Atrial Fibrillation, Persistent
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: Washington Cancer Institute at MedStar Washington Hospital Center, Washington, D.C., District of Columbia
Conditions: HER2-positive Advanced Solid Tumor
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Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
NCT05012475
Recruiting
Using a tele-research approach, we will recruit, enroll, guide and support carers and participants to engage in computer based activities (modified virtual reality) with the primary outcome of reducing stereotypies and increasing independent arm and hand use and secondary outcome of improving quality of living. Because of our virtual approach, we are able to recruit from multiple countries and all states and territories of the USA.
Gender:
ALL
Ages:
Between 4 years and 60 years
Trial Updated:
10/01/2024
Locations: Georgetown University School of Medicine, Washington, District of Columbia
Conditions: Rett Syndrome
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Diet, Hepcidin, and Chemotherapy RDI
NCT06483997
Recruiting
This prospective, observational cohort study will evaluate the extent of associations between self-reported pro- or anti- inflammatory dietary intake patterns for one month before induction chemotherapy for gynecological cancer or neo/adjuvant chemotherapy for breast cancer and baseline serum hepcidin concentrations. Associations between hepcidin concentration and relative dose intensity (RDI) of chemotherapy will also be evaluated.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
09/30/2024
Locations: George Washington University Cancer Center, Washington, District of Columbia
Conditions: Breast Cancer Female, Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, Endometrial Cancer, Gynecologic Cancer
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Prevent Cardiac Surgery Associated AKI Trial
NCT06620523
Recruiting
Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the first dose will be given the day before surgery and continues while admitted up to 1 week. Blood and urine samples will be collected. Adverse events related to the study drugs will be collected.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/29/2024
Locations: George Washington University Hospital, Washington, District of Columbia
Conditions: Renal Failure, Coronary Artery Disease, Surgery, Surgery-Complications
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Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry
NCT05052606
Recruiting
INSIGHTS is a registry research study that collects key information on medical history for girls and women with Turner syndrome and the clinical care they receive. This includes genetic tests, imaging, medications, and more for hundreds of patients seen at a number of clinics across the US. In addition to learning a lot about the current state of health for individuals with TS, INSIGHTS serves as an infrastructure to conduct future studies are meaningful to patients and their families.
Gender:
FEMALE
Ages:
All
Trial Updated:
09/27/2024
Locations: Children's National, Washington, District of Columbia
Conditions: Turner Syndrome
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Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)
NCT06193759
Recruiting
This is an open-label phase 1 safety and feasibility study that will employ multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA) derived from a patient's primary brain tumor tissues. Young patients with embryonal central nervous system (CNS) malignancies typically are unable to receive irradiation due to significant adverse effects and are treated with intensive chemotherapy followed by autologous st... Read More
Gender:
ALL
Ages:
Between 1 day and 4 years
Trial Updated:
09/25/2024
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS, Embryonal Tumor With Multilayered Rosettes, Pineoblastoma, Embryonal Tumor of CNS
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Improving Genetic Counseling for BRCA+ Mothers
NCT04258280
Recruiting
Genetic counseling and testing for hereditary breast cancer may reveal that you, and possibly your blood relatives, are at increased risk for the disease across the lifespan. This includes biological children, both male and female. We do not yet know the best ways to educate mothers who have a risk gene (are BRCA+) about whether, when, and how to share genetic information with their children or manage their thoughts and feelings. The purpose of this study is to help mothers make more informed ch... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: MedStar Georgetown University Hospital, Washington, District of Columbia
Conditions: Breast Cancer
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Novel Device for Ultrasound-guided Pediatric Vessel Cannulations
NCT04039490
Recruiting
Clinical Trial to investigate whether the use of a novel device to be used in conjunction with ultrasound in pediatric vessel cannulations is superior to ultrasound-only pediatric vessel cannulations in terms of number of cannulation attempts.
Gender:
ALL
Ages:
Between 1 month and 17 years
Trial Updated:
09/25/2024
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Clinical Procedures Which Require Vessel Cannulations in Pediatric Patients
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Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
NCT03474029
Recruiting
This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI). This trial is conducted among persons who are at increased risk of progression to tuberculosis (TB) and require treatment of LTBI. The study will be conducted in low, medium and high TB incidence settings that have t... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
09/25/2024
Locations: George Washington University, Washington, District of Columbia
Conditions: Latent Tuberculosis
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