There are currently 536 clinical trials in Gainesville, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Florida /ID# 144834, University of Florida Health Science Center - Gainesville, University of Florida Shands Cancer Center and Sarkis Clinical Trials. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
NCT04573140
Recruiting
The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly diagnosed GBM (MGMT low level or unmethylated in adults only) and (Stratum 2) in pediatric patients with newly diagnosed HGG (pHGG). Funding Source - FDA OOPD
Gender:
ALL
Ages:
4 years and above
Trial Updated:
06/30/2025
Locations: UF Health, Gainesville, Florida
Conditions: Adult Glioblastoma, High Grade Glioma, WHO Grade III or IV Malignant Glioma
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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
NCT05624450
Recruiting
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/30/2025
Locations: Research Site, Gainesville, Florida
Conditions: Viral Lung Infection and Acute Respiratory Failure
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A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
NCT06455449
Recruiting
The purpose of this multicenter, randomized, placebo-controlled and double-blind study is to evaluate the efficacy and safety of subcutaneous anifrolumab compared with placebo on the overall disease activity in participants with moderate to severe Idiopathic Inflammatory Myopathies (IIM) \[polymyositis (PM) or dermatomyositis (DM)\] while receiving standard of care (SoC) treatment.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/30/2025
Locations: Research Site, Gainesville, Florida
Conditions: Polymyositis, Dermatomyositis
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OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial
NCT06558214
Recruiting
In this study we are evaluating the safety and feasibility of the triple combination (TTFields, MLA, pembrolizumab) in adult patients diagnosed with recurrent or progressive glioblastoma (GBM) WHO Grade IV, IDH wild type or recurrent or progressive astrocytoma WHO grade IV.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
06/30/2025
Locations: UF Health Shands Hospital, Gainesville, Florida
Conditions: Recurrent Glioblastoma
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The Study of Urinary Biomarkers in Patients With Hypomagnesemia
NCT07056283
Recruiting
In this pilot exploratory study, we aim to examine extracellular vesicles (EVs) as biomarkers in urine from up to 15 patients, with up to 10 samples per patient among the patients with a history of hypomagnesemia.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/29/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Hypomagnesemia
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Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
NCT03876223
Recruiting
The purpose of this study is to examine small vessel disease (a condition in which the small arteries in the heart become narrowed). The investigators want to know how the small vessel disease contributes to pre-HFpEF (a condition with inadequate heart muscle function in the setting of preserved muscle pumping) and to better identify potential treatment for prevention of HFpEF. The main procedures of this study include up to 2 clinic visits (initial visit and a second clinical visit only if part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF), Coronary Microvascular Dysfunction
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TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer
NCT05507879
Recruiting
This study examines TRPC6 in predicting and preventing chemotherapy related cardiac toxicity and heart failure in patients with breast cancer. Cardiac toxicity, changes in heart function is a well-recognized complication of certain cancer related therapies. Understanding these changes may allow early intervention against therapy-related cardiac toxicity and also identify novel therapeutic targets to protect patient long-term cardiac health. Studying samples of blood from patients with breast can... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Breast Carcinoma, Cardiomyopathy, Congestive Heart Failure
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Study to Evaluate ACDN-01 in ABCA4-related Stargardt Retinopathy (STELLAR)
NCT06467344
Recruiting
This study is an open-label, single ascending dose clinical trial in participants who have ABCA4-related retinopathies. This is the first-in-human clinical trial in which ACDN-01 will be evaluated for safety, tolerability, and preliminary efficacy following a single subretinal injection of ACDN-01.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: Vitreo Retinal Associates, Gainesville, Florida
Conditions: Stargardt Disease, Cone Rod Dystrophy, Juvenile Macular Degeneration, Stargardt Disease 1
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Group Integrative Breathwork for Chronic Pain
NCT06977984
Recruiting
The aim of the proposed research is to iteratively develop, pilot test, and refine an integrative breathwork intervention that is suitable for group delivery to individuals with chronic pain. The intervention will be evaluated for feasibility, acceptability, and plausibility for clinically significant effects in people with chronic musculoskeletal pain.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/27/2025
Locations: University of Florida Clinical Research Center, Gainesville, Florida
Conditions: Chronic Pain
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Non-invasive Nerve Stimulation for PTSD and Sleep
NCT03170440
Recruiting
In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/26/2025
Locations: UF Health Jacksonville, Gainesville, Florida +1 locations
Conditions: Post Traumatic Stress Disorder, Traumatic Brain Injury
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Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
NCT03814317
Recruiting
This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/26/2025
Locations: University of Florida, Division of Pulmonary and Critical Care Medicine, Gainesville, Florida
Conditions: Sarcoidosis, Precapillary Pulmonary Hypertension, Interstitial Lung Disease
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A Media Parenting Prevention Intervention
NCT05332275
Recruiting
Entertainment media commonly depict SU, and youth exposure to media SU is linked to youth initiation and progression of SU behavior. Parenting practices reduce exposure to and may mitigate risk associated with media depictions of SU, thus this research proposal will build upon current understanding of effective media parenting with the end goal of developing and testing a media parenting intervention designed to reduce youth risk for SU.
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
06/26/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Substance Related Problem
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