There are currently 697 clinical trials in Orlando, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including AdventHealth Orlando, Orlando Clinical Research Center, GSK Investigational Site and Nemours Children's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
NCT04408625
Recruiting
Study J4B-MC-OKAA is a Phase 1/2, multi-center, open-label ascending dose, first-in-human study that will evaluate the safety and effect of intra-cisternal LY3884963 administration on progranulin protein (PGRN) levels in patients with frontotemporal dementia with progranulin mutations (FTD-GRN). Two escalating dose (low dose and medium dose) cohorts are planned, as well as one bridging cohort which will allocate patients to receive either low or medium dose. The duration of the study is 5 years.... Read More
Gender:
ALL
Ages:
Between 30 years and 85 years
Trial Updated:
03/14/2025
Locations: PPD Phase 1 Clinic, 100 West Gore Street, Suite 202, Orlando, Florida
Conditions: Frontotemporal Dementia
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Efficacy, Safety & Pharmacokinetic (PK) Study of HLD200 in Children Aged 4-5 Years with ADHD
NCT06431256
Recruiting
This study will evaluate the efficacy, safety and pharmacokinetics of HLD200 (20 mg and 40 mg) in children aged 4 to 5 years with ADHD.
Gender:
ALL
Ages:
Between 4 years and 5 years
Trial Updated:
03/14/2025
Locations: HLD200-112 Study Site, Orlando, Florida
Conditions: Attention Deficit Hyperactivity Disorder
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Magnetic Resonance & Optical Spectroscopy Validation
NCT01827527
Recruiting
The purpose of this study is to develop and refine techniques for using magnetic resonance and optical spectroscopy to investigate how your body uses energy.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
03/12/2025
Locations: Translational Research Institute for Metabolism and Diabetes, Orlando, Florida
Conditions: Validation Studies, Magnetic Resonance Spectroscopy
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The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
NCT03761446
Recruiting
The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
03/12/2025
Locations: Translational Research Institute for Metabolism and Diabetes, Orlando, Florida
Conditions: Muscle Atrophy, Aging, Sedentary Behavior, Type 2 Diabetes, Pre-diabetes
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Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells (MoTrMyo)
NCT04334343
Recruiting
The goal of the study is to examine the ability of resistance or aerobic exercise training to "imprint" skeletal muscle cells in a manner which confers long-term changes in this tissue which in-turn contribute to improved metabolic health and functional capacity through epigenetic regulation of novel exercise response genes. This study will also provide primary human skeletal muscle cells to the Molecular Transducers of Physical Activity Consortium (MoTrPAC) (NCT03960827) repository for future u... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: AdventHealth Translational Research Institute, Orlando, Florida
Conditions: Physical Activity
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AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)
NCT04807868
Recruiting
The purpose of this study is to create a resource that will advance research that is focused on discovery of novel therapies, risk stratification, and aggressive interventions for those at highest risk for non-alcoholic fatty liver disease (NAFLD). To achieve this, we will generate a biobank of liver tissue collected during standard of care liver biopsies. Paired blood/urine samples, FibroScan and relevant data will also be collected.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: AdventHealth Translational Research Institute, Orlando, Florida
Conditions: Non-Alcoholic Fatty Liver Disease
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ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks
NCT05820490
Recruiting
The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
03/12/2025
Locations: AdventHealth Translational Research Institute, Orlando, Florida
Conditions: Metabolic Health
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A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
NCT04636814
Recruiting
The purpose of this study is to evaluate the efficacy and the safety of two doses of CHF6001 (Tanimilast) as add-on to maintenance triple therapy in the target patient population.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
03/11/2025
Locations: Chiesi Clinical Trial - Site 840524, Orlando, Florida +1 locations
Conditions: Chronic Obstructive Pulmonary Disease
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A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients with Advanced Solid Tumors
NCT06384352
Recruiting
This is a multicenter, open-label, Phase 1 study. The study will enroll subjects with advanced solid tumors. It consists of three parts. Part 1 is dose-escalation part. In part 1, the safety and tolerability of YL211 in patients with selected advanced solid tumors will be evaluated and the MTD and RED will be determined. Part 2 is backfill enrollment part. We will further estimate the safety and efficacy of YL211 in patients with selected adcance tumor to select the RED(s) of YL211. Part 3 is... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando, Florida
Conditions: Advanced Solid Tumors
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A Study to Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis
NCT06723535
Recruiting
The purpose of this study is to assess the effect of severe renal impairment (RI) and end-stage renal disease (ESRD) with intermittent hemodialysis (IHD) on the pharmacokinetics and safety of BMS-986278. This study plans to use a staged design based on RI severity.
Gender:
ALL
Ages:
Between 18 years and 84 years
Trial Updated:
03/11/2025
Locations: Omega Research Group, LLC - Orlando, Orlando, Florida +1 locations
Conditions: Kidney Failure, Chronic, Healthy Volunteers, Renal Impairment
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A Varegacestat Hepatic Impairment Study
NCT06841315
Recruiting
This clinical trial is designed to determine the pharmacokinetics, safety and tolerability of varegacestat in people with impaired liver function compared to people with normal liver function.
Gender:
ALL
Ages:
Between 18 years and 84 years
Trial Updated:
03/10/2025
Locations: Orlando Clinical Research Center, Orlando, Florida
Conditions: Healthy Volunteer, Hepatic Impairment (HI)
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University of Central Florida CereBank
NCT06876857
Recruiting
Millions of persons are affected by brain diseases. The CereBank will be used to support research studies aimed at improving the diagnosis and treatment of brain diseases. Brain diseases can be inherited; developed due to diseases or aging; or can be due to trauma. The Central Florida does not have a brain biobank to meet the needs of research. Therefore, it is necessary for the University of Central Florida to establish a brain biobank.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: University of Central Florida, Orlando, Florida
Conditions: Biospecimen Donation, Brain Injury, Brain Diseases
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