Crohn's Disease Clinical Trials

A listing of 30 Crohn's Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 30 active clinical trials seeking participants for Crohn's Disease research studies. The states with the highest number of trials for Crohn's Disease participants are Florida, Texas, California and New York.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Pediatric IBD Study

Recruiting

Is your 2-17 year old living with Crohn's Disease or Ulcerative Colitis? A clinical trial is currently open to enroll
2-17-year-olds. Eligible participants will receive study-related medical care at no cost. Health insurance is not required.

Conditions:

Ulcerative Colitis

Colitis

Ulcerative

Ulcerative Colitis (UC)

Active Ulcerative Colitis

Learn More

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

NCT03167437

Recruiting

Background: Crohn s disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut. Symptoms may include diarrhea, abdominal pain, fatigue, weight loss and malnutrition. CD has no cure, but symptoms can sometimes be controlled with medicine. Researchers want to see if it is safe to treat CD with the medicine vorinostat. It is thought that vorinostat may reduce the inflammation process of CD. This may then help to relieve symptoms of CD. Participants who respond to Vorinostat will be invited to an extension phase of treatment with Vorinostat and possibly a maintenance treatment using Ustekinumab. Objectives: To see if vorinostat is safe for people with moderate-to-severe CD. To see if it is safe for people with moderate-to-sever CD to receive maintenance therapy using Ustekinumab after successful treatment of Vorinostat. Eligibility: Adults 18-65 with moderate-to-severe CD that medicine is not controlling. Design: Phase I is screening. It may last 120 days. Participants will have: Physical exam Medical history Tests of blood, urine, and stool samples Heart test Questionnaires Tuberculosis skin test They may have a colonoscopy and lymphapheresis collection. These will be explained in a separate consent. They will keep a diary of symptoms. Phase II is treatment using Vorinostat. It will take 12-13 weeks. Participants will take the study drug by mouth twice daily for 12 weeks. They will get a weekly phone call to talk about how the drug makes them feel. They will have blood taken regularly. Every 4 weeks, they will have a check-up that will repeat some screening tests. Phase III extension treatment of Vorinostat for an additional 6 months for those who respond to vorinostat and it is safe for them to continue treatment. Participants will continue to receive weekly calls to talk about how the drug makes them feel. They will have blood taken regularly. Every 3 months, they will have a check-up that will repeat some screening tests. Phase IV: is maintenance therapy for 2 years with Ustekinumab. Participants will receive a one time loading dose of ustekinumab, and then will receive the approved maintenance dose once every 8 weeks, at which time they will return to the NIH Clinical Center for evaluation. The participant will get a phone call 3 days after each dose and again 2 weeks later to see how the drug makes them feel. After two years of receiving treatment with ustekinumab the participant will have an end of study visit, where some of the screening tests, including a colonoscopy, will be repeated. Read Less

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

07/12/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Crohn's Disease

Learn More ›

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

NCT06548542

Recruiting

Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD.... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

07/11/2025

Locations: Digestive Health Specialists /ID# 266216, Dothan, Alabama +219 locations

Digestive Health Specialists /ID# 266216, Dothan, Alabama

East View Medical Research /ID# 270377, Mobile, Alabama

Southern California Res. Ctr /ID# 265549, Coronado, California

UC San Diego Health System /ID# 265565, La Jolla, California

uc davis medical center - patient support services building /ID# 265554, Sacramento, California

Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391, San Diego, California

Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557, Colorado Springs, Colorado

Danbury Hospital, Western Connecticut Health Network /ID# 265556, Danbury, Connecticut

Yale University School of Medicine /ID# 266786, New Haven, Connecticut

Nature Coast Clinical Research - Inverness /ID# 265874, Inverness, Florida

Atlantic Medical Research /ID# 266207, Margate, Florida

A Plus Research /ID# 265878, Miami, Florida

Sanchez Clinical Research /ID# 265887, Miami, Florida

Advanced Research Institute, Inc /ID# 265548, New Port Richey, Florida

Hillcrest Medical Research, LLC /ID# 267237, Orange City, Florida

Endoscopic Research, Inc. /ID# 267211, Orlando, Florida

AdventHealth Medical Group - Tampa - Bruce B Downs Boulevard /ID# 265538, Tampa, Florida

Florida Medical Clinic - Zephyrhills /ID# 267392, Zephyrhills, Florida

Gastroenterology Associates of Central Georgia /ID# 265547, Macon, Georgia

Treasure Valley Medical Research /ID# 267114, Boise, Idaho

University of Chicago Medical Center /ID# 267400, Chicago, Illinois

OSF St. Francis Medical Center /ID# 266973, Peoria, Illinois

Springfield Clinic Main Campus /ID# 267434, Springfield, Illinois

University of Kentucky Chandler Medical Center /ID# 265564, Lexington, Kentucky

Metropolitan Gastroenterology Group - Chevy Chase /ID# 265877, Chevy Chase, Maryland

Lucida Clinical Trials /ID# 266548, New Bedford, Massachusetts

Henry Ford Medical Center - Columbus /ID# 266503, Novi, Michigan

Mayo Clinic - Rochester /ID# 265550, Rochester, Minnesota

GI Associates Research, LLC /ID# 267433, Columbia, Missouri

BVL Clinical Research /ID# 265870, Liberty, Missouri

Washington University School of Medicine - St. Louis /ID# 266938, Saint Louis, Missouri

Vector Clinical Trials /ID# 265561, Las Vegas, Nevada

NYU Langone Long Island Clinical Research Association /ID# 265566, Great Neck, New York

Icahn School of Medicine at Mount Sinai /ID# 266857, New York, New York

Lenox Hill Hospital /ID# 265527, New York, New York

Care Access - Yonkers /ID# 266781, Yonkers, New York

Digestive Health Partners - Biltmore Office /ID# 265539, Asheville, North Carolina

Velocity Clinical Research - Durham /ID# 267712, Durham, North Carolina

University of Cincinnati /ID# 265589, Cincinnati, Ohio

The Ohio State University /ID# 265577, Columbus, Ohio

Digestive Disease Specialists - Oklahoma /ID# 265901, Oklahoma City, Oklahoma

Penn State Health Milton South Hershey Medical Center /ID# 267126, Hershey, Pennsylvania

University of Pennsylvania /ID# 265904, Philadelphia, Pennsylvania

Gastroenterology Associates of Orangeburg /ID# 267548, Orangeburg, South Carolina

GI associates of Northeast Tennessee /ID# 265567, Johnson City, Tennessee

Gi Alliance - Cedar Park /ID# 268153, Cedar Park, Texas

Proactive Clinical Research /ID# 267305, El Paso, Texas

Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 266935, Garland, Texas

Houston Methodist Hospital /ID# 265533, Houston, Texas

Caprock Gastro Research - Lubbock - 80th Street /ID# 265541, Lubbock, Texas

GI Alliance: Mansfield /ID# 266947, Mansfield, Texas

Clinical Associates in Research Therapeutics of America, LLC /ID# 265899, San Antonio, Texas

Sun Research Institute /ID# 266723, San Antonio, Texas

Texas Digestive Disease Consultants - Southlake /ID# 265576, Southlake, Texas

Tyler Research Institute, LLC /ID# 265545, Tyler, Texas

Care Access - Ogden /ID# 266428, Ogden, Utah

Care Access - Salt Lake City /ID# 266785, Salt Lake City, Utah

Washington Gastroenterology - Tacoma /ID# 267302, Tacoma, Washington

Ordensklinikum Linz - Barmherzige Schwestern /ID# 265929, Linz, Oberoesterreich

Klinikum Wels-Grieskirchen GmbH /ID# 266035, Wels, Oberoesterreich

Medizinische Universitaet Graz /ID# 275453, Graz, Steiermark

Medizinische Universitaet Innsbruck /ID# 265930, Innsbruck, Tirol

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 265928, Salzburg, Not set

Medizinische Universitaet Wien /ID# 265926, Wien, Not set

Imelda Ziekenhuis /ID# 265995, Bonheiden, Antwerpen

Universite Libre de Bruxelles - Hopital Erasme /ID# 265993, Anderlecht, Bruxelles-Capitale

CHU Saint-Pierre /ID# 266431, Brussels, Bruxelles-Capitale

Cliniques Universitaires UCL Saint-Luc /ID# 265521, Bruxelles, Bruxelles-Capitale

CHU de Liège /ID# 265542, Liège, Liege

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 265517, Yvoir, Namur

UZ Leuven /ID# 265519, Leuven, Vlaams-Brabant

AZ Groeninge /ID# 265544, Kortrijk, West-Vlaanderen

Groupe Sante CHC - Clinique du MontLegia /ID# 265522, Liege, Not set

Hospital Tsaritsa Yoanna /ID# 266235, Sofiya, Sofia

Medical Center - Doverie /ID# 267050, Sofiya, Sofia

ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 266239, Sofiya, Sofia

Umbal Kaspela /ID# 266234, Plovdiv, Not set

2nd Mhat /ID# 266238, Sofia, Not set

Acibadem City Clinic Tokuda University Hospital EAD /ID# 267437, Sofia, Not set

Military Medical Academy Multiprofile Hospital /ID# 267051, Sofia, Not set

Multiprofile Hospital for Active Treatment Sveta Marina /ID# 266237, Varna, Not set

University of Calgary /ID# 265524, Calgary, Alberta

Gastroenterology and Internal Medicine Research Institute /ID# 265610, Edmonton, Alberta

London Health Sciences Centre - University Hospital /ID# 267298, London, Ontario

Toronto Digestive Disease Associates /ID# 267358, Vaughan, Ontario

Diex Recherche Quebec Inc. /ID# 265611, Quebec, Not set

Poliklinika Solmed /ID# 265509, Zagreb, Grad Zagreb

Poliklinika Borzan d.o.o. /ID# 265503, Osijek, Osjecko-baranjska Zupanija

Klinicki Bolnicki Centar (KBC) Split /ID# 265511, Split, Splitsko-dalmatinska Zupanija

Specijalna bolnica Medico Rijeka /ID# 265504, Rijeka, Not set

Hepato-Gastroenterologie HK /ID# 265387, Hradec Králové, Hradec Kralove

SurGal Clinic /ID# 265388, Brno, Jihomoravsky Kraj

Iscare Klinické Centrum /ID# 265407, Prague, Praha 9

East Tallinn Central Hospital /ID# 267658, Tallinn, Harjumaa

Medicum /ID# 268304, Tallinn, Harjumaa

Tartu University Hospital /ID# 267656, Tartu, Not set

Chu de Nice-Hopital L'Archet Ii /Id# 267478, Nice, Alpes-Maritimes

Centre Hospitalier Universitaire de Bordeaux /ID# 265721, Pessac CEDEX, Gironde

CHU de Toulouse - Hôpital Rangueil /ID# 267479, Toulouse CEDEX 9, Haute-Garonne

CHU de Montpellier - Hopital Saint Eloi /ID# 265718, Montpellier, Herault

Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 265340, St-Priest-en-Jarez, Loire

CHRU de Nancy-Hopital Brabois Adultes /ID# 265703, Vandoeuvre les Nancy, Lorraine

Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 266851, Pierre Benite, Rhone

Clinique Jules Verne /ID# 267480, Nantes, Not set

Hôpital Saint Antoine /ID# 265725, Paris, Not set

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou /ID# 266848, Rennes, Not set

Universitaetsklinikum Freiburg /ID# 265755, Freiburg, Baden-Wuerttemberg

Universitaetsmedizin Mannheim /ID# 266961, Mannheim, Baden-Wuerttemberg

Universitaetsklinikum Ulm /ID# 266962, Ulm, Baden-Wuerttemberg

Universitaetsklinikum Erlangen /ID# 265927, Erlangen, Bayern

Markus Krankenhaus /ID# 265938, Frankfurt am Main, Hessen

Universitaetsklinikum Frankfurt /ID# 266827, Frankfurt, Hessen

Klinikum Lueneburg /ID# 266886, Lueneburg, Niedersachsen

St. Marien- und St. Annastiftskrankenhaus /ID# 265912, Ludwigshafen am Rhein, Rheinland-Pfalz

Universitaetsklinikum des Saarlandes /ID# 265753, Homburg, Saarland

Studiengesellschaft BSF Unternehmergesellschaft /ID# 265751, Halle (Saale), Sachsen-Anhalt

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 265931, Dresden, Sachsen

Eugastro /ID# 266826, Leipzig, Sachsen

Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 265738, Kiel, Schleswig-Holstein

Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 267254, Lübeck, Schleswig-Holstein

Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 265752, Berlin, Not set

DRK Kliniken Berlin - Westend /ID# 265925, Berlin, Not set

Krankenhaus Waldfriede /ID# 266676, Berlin, Not set

Debreceni Egyetem-Klinikai Kozpont /ID# 267389, Debrecen, Hajdu-Bihar

Clinfan /ID# 267385, Szekszárd, Tolna

Synexus Hungary Clinical Research Centre - Budapest /ID# 267384, Budapest, Not set

Semmelweis Egyetem /ID# 267064, Budapest, Not set

Semmelweis Egyetem /ID# 267068, Budapest, Not set

Szegedi Tudományegyetem /ID# 267386, Szeged, Not set

Portiuncula University Hospital /ID# 267771, Ballinasloe, Galway

Our Lady of Lourdes Hospital - Drogheda /ID# 267768, Drogheda, Louth

Midland Regional Hospital Mullingar /ID# 267769, Mullingar, Westmeath

St. Vincent's University Hospital /ID# 267766, Dublin, Not set

Beaumont Hospital /ID# 267770, Dublin, Not set

Connolly Hospital /ID# 268021, Dublin, Not set

Soroka Medical Center /ID# 267235, Be'er Sheva, HaDarom

Edith Wolfson Medical Center /ID# 267640, Holon, HaMerkaz

Tel Aviv Sourasky Medical Center /ID# 267307, Tel Aviv, Tel-Aviv

Rambam Health Care Campus /ID# 267641, Haifa, Not set

Azienda Ospedaliero Universitaria di Cagliari - P.O. Duilio Casula /ID# 267287, Monserrato, Cagliari

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 267143, San Giovanni Rotondo, Foggia

IRCCS Istituto Clinico Humanitas /ID# 265946, Rozzano, Lombardia

IRCCS Ospedale San Raffaele /ID# 265951, Milan, Milano

Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 265935, Rome, Roma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 265940, Rome, Roma

A.O. Ordine Mauriziano di Torino /ID# 267144, Turin, Torino

IRCCS Ospedale Sacro Cuore Don Calabria /ID# 265942, Negrar, Verona

Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 267722, Catanzaro, Not set

Azienda Ospedaliera Universitaria Gaetano Martino /ID# 267145, Messina, Not set

Inje University Haeundae Paik Hospital /ID# 266380, Busan, Busan Gwang Yeogsi

Dong-A University Medical Center /ID# 266709, Busan, Busan Gwang Yeogsi

The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 265488, Daejeon, Daejeon Gwang Yeogsi

Chungang University Hospital /ID# 266427, Dongjak-gu, Seoul Teugbyeolsi

Samsung Medical Center /ID# 265489, Seoul, Seoul Teugbyeolsi

Kyungpook National University Chilgok Hospital /ID# 265487, Daegu, Not set

Liepaja Regional Hospital /ID# 267703, Liepaja, Not set

Pauls Stradins Clinical University Hospital /ID# 267705, Riga, Not set

Digestive Diseases Center GASTRO /ID# 267707, Riga, Not set

Hospital of Lithuanian University of Health Sciences Kaunas /ID# 267695, Kaunas, Not set

Panevezys Republican Hospital /ID# 267709, Panevezys, Not set

Vilnius University Hospital Santaros Klinikos /ID# 267711, Vilnius, Not set

Elisabeth TweeSteden Ziekenhuis /ID# 265729, Tilburg, Noord-Brabant

Amsterdam UMC, locatie AMC /ID# 268321, Amsterdam, Noord-Holland

Universitair Medisch Centrum Groningen /ID# 265736, Groningen, Not set

Universitair Medisch Centrum Utrecht /ID# 265731, Utrecht, Not set

Akershus University Hospital /ID# 267642, Lørenskog, Akershus

Helse More- og Romsdal HF, Alesund sjukehus /ID# 267632, Alesund, More Og Romsdal

Oslo Universitetssykehus Ulleval /ID# 267630, Oslo, Not set

NZOZ Centrum Medyczne KERmed /ID# 266766, Bydgoszcz, Kujawsko-pomorskie

Gastromed Sp. z o.o /ID# 266765, Torun, Kujawsko-pomorskie

Malopolskie Centrum Kliniczne /ID# 265943, Krakow, Malopolskie

Medical Network Sp.z.o.o. WIP Warsaw IBD Point Profesor Kierkus /ID# 266764, Warsaw, Mazowieckie

Bodyclinic Sp. z o.o. sp.k. /ID# 265945, Warszawa, Mazowieckie

Endoskopia Sp. z.o.o. /ID# 265934, Sopot, Pomorskie

H-T Centrum Medyczne Endoterapia /ID# 265937, Tychy, Slaskie

Polimedica PTG Kielce /ID# 267066, Kielce, Swietokrzyskie

Unidade Local de Saude do Alto Ave, EPE /ID# 265892, Guimaraes, Braga

2CA-Braga, Hospital de Braga /ID# 265894, Braga, Not set

Unidade Local de Saude de Coimbra, EPE /ID# 267240, Coimbra, Not set

Unidade Local de Saude de Lisboa Ocidental, EPE /ID# 267242, Lisboa, Not set

Unidade Local de Saude de Santa Maria, EPE /ID# 266113, Lisboa, Not set

Unidade Local de Saude do Alto Minho, EPE - Hospital de Santa Luzia /ID# 265885, Viana Do Castelo, Not set

Memorial Healthcare International S.R.L. /Id# 267328, Bucharest, Bucuresti

Spitalul Clinic Colentina /ID# 267208, Bucharest, Bucuresti

Clinica Gastro Med SRL /ID# 267204, Cluj-Napoca, Cluj

OncoHelp Association /ID# 267203, Timișoara, Timis

Clinical Hospital Center Zvezdara /ID# 265605, Belgrade, Beograd

University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" /ID# 265607, Belgrade, Beograd

Clinical Hospital Center - Bežanijska Kosa /ID# 265604, Belgrade, Beograd

Leskovac General Hospital /ID# 265606, Leskovac, Jablanicki Okrug

General Hospital Djordje Joanovic /ID# 266040, Zrenjanin, Vojvodina

University Clinical Center Vojvodina /ID# 265603, Novi Sad, Not set

Gastroenterology and Liver Specialist Clinic /ID# 268354, Singapore, Central Singapore

Gleneagles Hospital /ID# 268385, Singapore, Central Singapore

National University Hospital /ID# 268128, Singapore, Not set

Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 266064, Banska Bystrica, Banskobystricky Kraj

KM Management, spol. s.r.o. /ID# 266070, Nitra, Nitriansky Kraj

Gastro I., s.r.o. /ID# 267159, Prešov, Presovsky Kraj

ENDOMED s.r.o /ID# 266068, Košice, Not set

General Hospital Celje /ID# 267699, Celje, Not set

University Medical Centre Ljubljana /ID# 267697, Ljubljana, Not set

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 266902, Santiago de Compostela, A Coruna

Hospital Universitario Virgen Macarena /ID# 266648, Seville, Sevilla

Hospital Universitario Virgen del Rocio /ID# 266727, Seville, Sevilla

Hospital Clinic de Barcelona /ID# 265415, Barcelona, Not set

Hospital Universitario 12 de Octubre /ID# 265444, Madrid, Not set

Hospital Universitario La Paz /ID# 265412, Madrid, Not set

Hospital Alvaro Cunqueiro /ID# 266647, Pontevedra, Not set

Hospital Universitari i Politècnic La Fe /ID# 265478, Valencia, Not set

Intesto /ID# 265728, Bern, Not set

Western General Hospital - NHS Lothian /ID# 266333, Edinburgh, Edinburgh, City Of

Gartnavel General Hospital /ID# 266407, Glasgow, Glasgow City

Royal Free Hospital /ID# 268065, London, Greater London

Guy's Hospital /ID# 266336, London, Greater London

St. George's Hospital /ID# 266335, London, Greater London

The John Radcliffe Hospital /ID# 266334, Oxford, Oxfordshire

The Royal Wolverhampton NHS Trust /ID# 268158, Guildford, Surrey

University Hospital Coventry & Warwickshire NHS Trust /ID# 267128, Coventry, Warwickshire

Barts Health NHS Trust /ID# 266410, London, Not set

Royal Victoria Infirmary /ID# 268064, Newcastle upon Tyne, Not set

Conditions: Crohn's Disease

Learn More ›

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

NCT06045754

Recruiting

The main aim of this study is to learn about the effect of treatment with vedolizumab IV (vedolizumab) together with adalimumab or vedolizumab (VDZ) together with ustekinumab (UST) in adults with moderate to severe Crohn's Disease, and the effect of treatment with vedolizumab alone, after the dual targeted treatment. The study is conducted in two parts. In Part A, participants will receive the dual targeted treatment (vedolizumab together with either adalimumab or ustekinumab). In part B, parti... Read More

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

07/10/2025

Locations: Digestive Health Specialsits, Dothan, Alabama +52 locations

Digestive Health Specialsits, Dothan, Alabama

GI Alliance Sun City, Sun City, Arizona

University of California San Diego Health (UCSD), La Jolla, California

Cedars-Sinai Medical Center, Los Angeles, California

Hoag Hospital Newport Beach, Newport Beach, California

Medical Research Center of Connecticut, LLC, Hamden, Connecticut

Endoscopic Research Inc, Orlando, Florida

Alliance Clinical Research of Tampa, LLC, Tampa, Florida

Gastroenterology Consultants, P.C., Roswell, Georgia

University of Chicago Medicine, Chicago, Illinois

GI Alliance - Illinois Gastroenterology Group - Glenview, Glenview, Illinois

GI Alliance - Illinois Gastroenterology Group LLC - Gurnee, Gurnee, Illinois

University of Kansas Medical Center, Kansas City, Kansas

Cotton ONeil Clinical Research Center, Topeka, Kansas

University of Louisville, Louisville, Kentucky

GI Alliance, Metairie, Louisiana

Tulane University, New Orleans, Louisiana

Huron Gastroenterology Associates, P.C., Ypsilanti, Michigan

Mid-America Gastro-Intestinal Consultants, Kansas City, Missouri

BVL Clinical Research, Liberty, Missouri

Washington University School of Medicine, Saint Louis, Missouri

NYU Langone Health, New York, New York

University of Cincinnati, Cincinnati, Ohio

Ohio Gastroenterology group, Inc., Columbus, Ohio

Great Lakes Gastroenterology Research, LLC, Mentor, Ohio

Gastro Intestinal Research Institute of Northern Ohio, LLC., Westlake, Ohio

Digestive Disease Specialists, Inc., Oklahoma City, Oklahoma

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Allegheny Health Network, Wexford, Pennsylvania

University Gastroenterology, Providence, Rhode Island

Rapid City Medical Center, LLP, Rapid City, South Dakota

Texas Digestive Disease Consultants Cedar Park, Cedar Park, Texas

GI Alliance - Digestive Health Associates of Texas, Dallas, Texas

The University of Texas Health Science Center at Houston, Houston, Texas

Texas Digestive Disease Consultants Lubbock, Lubbock, Texas

GI Alliance - Mansfield, Mansfield, Texas

Gastroenterology Research of San Antonio, LLC, San Antonio, Texas

Southern Star Research Institute, LLC., San Antonio, Texas

Texas Digestive Disease Consultants (TDDC), Southlake, Southlake, Texas

Tyler Research Institute, LLC, Tyler, Texas

GI Alliance - Webster, Webster, Texas

University of Utah Health, Salt Lake City, Utah

Washington Gastroenterology- GIA, Bellevue, Washington

Washington Gastroenterology- GIA, Tacoma, Washington

Covenant Health, Edmonton, Alberta

London Health Sciences Centre, London, Ontario

West GTA Endoscopy Inc., Mississauga, Ontario

Viable Clinical Research - North Bay, North Bay, Ontario

Toronto Immune and Digestive Health Institute Inc. (TIDHI), North York, Ontario

ABP Research Services Corp., Oakville, Ontario

Taunton Surgical Centre, Oshawa, Ontario

Toronto Digestive Disease Associates (TDDA) Specialty Research, Vaughan, Ontario

McGill University Health Centre Montreal General Hospital, Montreal, Quebec

Conditions: Crohn's Disease

Learn More ›

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

NCT06430801

Recruiting

The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to severely active Crohn's disease. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week... Read More

Gender:

ALL

Ages:

Between 16 years and 80 years

Trial Updated:

07/10/2025

Locations: Digestive Health Specialists ( Site 5064), Dothan, Alabama +404 locations

Digestive Health Specialists ( Site 5064), Dothan, Alabama

Arizona Arthritis & Rheumatology Research, PC ( Site 5094), Phoenix, Arizona

GI Alliance - Sun City ( Site 5118), Sun City, Arizona

University of Arizona Clinical and Translational Sciences Research Center ( Site 5111), Tucson, Arizona

Clinnova Research ( Site 5110), Anaheim, California

Southern California Research Center ( Site 5044), Coronado, California

Om Research LLC ( Site 5038), Lancaster, California

UCLA Clinical & Translational Research Center (CTRC) ( Site 5116), Los Angeles, California

Om Research LLC ( Site 5045), Oxnard, California

Amicis Research Center - Valencia ( Site 5055), Valencia, California

University of Colorado Anschutz Medical Campus-Division of Gastroenterology and Hepatology ( Site 5026), Aurora, Colorado

Peak Gastroenterology Associates ( Site 5023), Colorado Springs, Colorado

South Denver Gastroenterology, PC ( Site 5132), Englewood, Colorado

Medical Research Center of Connecticut ( Site 5005), Hamden, Connecticut

Emerson Clinical Research Institute ( Site 5051), Washington, District of Columbia

Gastroenterology Consultants of Clearwater ( Site 5052), Clearwater, Florida

Nature Coast Clinical Research - Inverness ( Site 5042), Inverness, Florida

Atlantic Medical Research ( Site 5073), Margate, Florida

Endoscopic Research Inc ( Site 5061), Orlando, Florida

Orlando Health-Digestive Health Institute ( Site 5010), Orlando, Florida

USF Health Carol and Frank Morsani Center for Advanced Healthcare ( Site 5039), Tampa, Florida

Atlanta Center for Gastroenterology ( Site 5035), Decatur, Georgia

Gastroenterology Associates of Central Georgia ( Site 5048), Macon, Georgia

Eagle Clinical Research ( Site 5089), Chicago, Illinois

University of Chicago Medical Center ( Site 5066), Chicago, Illinois

Endeavor Health ( Site 5018), Evanston, Illinois

GI ALLIANCE - GURNEE ( Site 5003), Gurnee, Illinois

Indiana University Health University Hospital ( Site 5022), Indianapolis, Indiana

Iowa Digestive Disease Center ( Site 5007), Clive, Iowa

Cotton O'Neil Digestive Health Center ( Site 5033), Topeka, Kansas

Massachusetts General Hospital-Crohn's and Colitis Center ( Site 5037), Boston, Massachusetts

University of Michigan ( Site 5060), Ann Arbor, Michigan

Clinical Research Institute of Michigan, LLC ( Site 5002), Clinton Township, Michigan

Mayo Clinic in Rochester, Minnesota ( Site 5024), Rochester, Minnesota

BVL Research - Kansas ( Site 5099), Liberty, Missouri

Washington University School of Medicine ( Site 5058), Saint Louis, Missouri

HMHN Justice Marie Garibaldi Medical Plaza ( Site 5072), Hackensack, New Jersey

Northwell Health Division of Gastroenterology at Great Neck ( Site 5017), Great Neck, New York

Circuit Clinical /Crystal Run Healthcare LLP ( Site 5050), Middletown, New York

NYU Langone Health - Inflammatory Bowel Disease Center (IBD) ( Site 5078), New York, New York

Weill Cornell Medical College, New-York Presbyterian Hospital ( Site 5079), New York, New York

New York Gastroenterology Associates ( Site 5013), New York, New York

University of North Carolina Medical Center ( Site 5034), Chapel Hill, North Carolina

Atrium Health Gastroenterology MMP ( Site 5105), Charlotte, North Carolina

Javara - Tryon Medical Partners ( Site 5046), Charlotte, North Carolina

Great Lakes Gastroenterology Research, LLC ( Site 5016), Mentor, Ohio

Digestive Disease Specialists Inc. ( Site 5117), Oklahoma City, Oklahoma

Frontier Clinical Research, LLC ( Site 5098), Uniontown, Pennsylvania

University Gastroenterology - Providence - West River Street ( Site 5057), Providence, Rhode Island

Vanderbilt Inflammatory Bowel Disease Clinic ( Site 5049), Nashville, Tennessee

Quality Medical Research ( Site 5114), Nashville, Tennessee

Baylor University Medical Center ( Site 5031), Dallas, Texas

GI Alliance - Dallas - Gaston Avenue ( Site 5054), Dallas, Texas

Baylor College of Medicine Medical Center ( Site 5020), Houston, Texas

GI Alliance - Lubbock ( Site 5012), Lubbock, Texas

Caprock Gastro Research ( Site 5077), Lubbock, Texas

GI Alliance: Mansfield ( Site 5015), Mansfield, Texas

Southern Star Research Institute ( Site 5000), San Antonio, Texas

GI Alliance - Southlake ( Site 5109), Southlake, Texas

Tyler Research Institute ( Site 5001), Tyler, Texas

Richmond VA Medical Center ( Site 5021), Richmond, Virginia

Washington Gastroenterology - Bellevue ( Site 5040), Bellevue, Washington

Swedish Medical Center ( Site 5112), Seattle, Washington

Washington Gastroenterology - Tacoma ( Site 5004), Tacoma, Washington

Concord Repatriation General Hospital-Gastroenterology and Liver Services ( Site 3202), Concord, New South Wales

Royal Brisbane and Women's Hospital ( Site 3200), Brisbane, Queensland

Royal Adelaide Hosp - GI Clinical Trials ( Site 3203), Adelaide, South Australia

Monash Health-Gastroenterology ( Site 3206), Clayton, Victoria

The Alfred Hospital-Gastroenterology ( Site 3201), Melbourne, Victoria

Medizinische Universitaet Innsbruck-Innere Medizin 1 ( Site 0200), Innsbruck, Tirol

Medizinische Universität Wien-Klinik für Innere Medizin III - Abteilung für Gastroenterologie und H ( Site 0202), Vienna, Wien

Uniklinikum Salzburg-Innere Medizin I ( Site 0201), Salzburg, Not set

UZ Gent ( Site 0300), Gent, Oost-Vlaanderen

UZ Leuven-Gastroenterology - Inflammatory Bowel Disease ( Site 0301), Leuven, Vlaams-Brabant

AZ Delta vzw-Gastroenterology ( Site 0304), Roeselare, West-Vlaanderen

Heritage Medical Research Clinic ( Site 0004), Calgary, Alberta

SIX08 Gastroenterology ( Site 0015), Lethbridge, Alberta

Fraser Clinical Trials Inc ( Site 0001), New Westminster, British Columbia

G.I.R.I. GI Research Institute Foundation ( Site 0018), Vancouver, British Columbia

Barrie GI Associates ( Site 0016), Barrie, Ontario

University Hospital - London Health Sciences Centre ( Site 0002), London, Ontario

Victoria Hospital & Children's Hospital - London Health Sciences Centre ( Site 0007), London, Ontario

West GTA Research Inc. ( Site 0020), Mississauga, Ontario

ABP Research Services Corp. ( Site 0019), Oakville, Ontario

Toronto Immune & Digestive Health Institute ( Site 0005), Toronto, Ontario

Toronto Digestive Disease Associates ( Site 0006), Vaughan, Ontario

Centre de recherche du CISSS de Chaudière-Appalaches - Hôpital Hôtel Dieu de Levis ( Site 0011), Levis, Quebec

Montreal General Hospital ( Site 0003), Montreal, Quebec

Diex Recherche Quebec ( Site 0008), Quebec, Not set

Hospital hernan henriquez aravena de temuco ( Site 2607), Temuco, Araucania

Hospital Clínico Regional Dr. Guillermo Grant Benavente ( Site 2604), Concepción, Biobio

FALP-UIDO ( Site 2600), Santiago, Region M. De Santiago

Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2602), Santiago, Region M. De Santiago

Espacio Eme ( Site 2608), Santiago, Region M. De Santiago

CECIM ( Site 2603), Santiago, Region M. De Santiago

Centro de Investigaciones Clinicas Vina del Mar ( Site 2606), Vina del Mar, Valparaiso

Anhui Provincial Hospital ( Site 3922), Hefei, Anhui

Peking University Third Hospital ( Site 3910), Beijing, Beijing

Chongqing General Hospital ( Site 3940), Chongqing, Chongqing

The First Affiliated Hospital Of Fujian Medical University ( Site 3916), Fuzhou, Fujian

The First Affiliated hospital of Xiamen University ( Site 3924), XiaMen, Fujian

Zhongshan Hospital Affiliated to Xiamen University ( Site 3923), Xiamen, Fujian

Dongguan People's Hospital ( Site 3933), Dongguan, Guangdong

The First Affiliated Hospital, Sun Yat-sen University ( Site 3901), Guangzhou, Guangdong

The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3907), Guangzhou, Guangdong

Huizhou Municipal Central Hospital ( Site 3915), Huizhou, Guangdong

The University of Hong Kong-Shenzhen Hospital ( Site 3930), Shenzhen, Guangdong

Shenzhen Hospital of Southern Medical University ( Site 3932), Shenzhen, Guangdong

The Second Afilliated Hospital of Hebei Medical University ( Site 3913), Shijiazhuang, Hebei

The Second Affiliated Hospital of Zhengzhou University ( Site 3909), Zhengzhou, Henan

Taihe Hospital ( Site 3944), Shiyan, Hubei

Renmin Hospital of Wuhan University ( Site 3921), Wuhan, Hubei

The Second Xiangya Hospital of Central South University-gastroenterology department ( Site 3905), Changsha, Hunan

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 3937), Nanjing, Jiangsu

Zhongda Hospital Southeast University-Gastroenterology ( Site 3911), Nanjing, Jiangsu

Wuxi People's Hospital ( Site 3925), Wuxi, Jiangsu

Affiliated Hospital of Jiangsu University ( Site 3919), Zhenjiang, Jiangsu

Changzhou No.2 People's Hospital ( Site 3904), Zhenjiang, Jiangsu

Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army ( Site 3918), Xian, Shaanxi

Ruijin Hospital Shanghai Jiaotong University School of Medicine ( Site 3931), Shanghai, Shanghai

Huashan Hospital of Fudan University ( Site 3946), Shanghai, Shanghai

Shanghai East Hospital ( Site 3914), Shanghai, Shanghai

West China Hospital, Sichuan University ( Site 3929), Cheng Du, Sichuan

Suining Central Hospital ( Site 3927), SuiNing, Sichuan

First Affiliated Hospital of Kunming Medical University ( Site 3928), Kunming, Yunnan

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-GI Medicine ( Site 3902), Hangzhou, Zhejiang

Taizhou Hospital of Zhejiang Province ( Site 3936), Taizhou, Zhejiang

Clinica Medellin S.A ( Site 2705), Medellín, Antioquia

IMAT S.A.S ( Site 2700), Monteria, Cordoba

Oncologos del Occidente ( Site 2702), Pereira., Risaralda

Fundación Valle del Lili ( Site 2704), Cali., Valle Del Cauca

Poliklinika Bates ( Site 0504), Zagreb, Grad Zagreb

Poliklinika Solmed ( Site 0502), Zagreb, Grad Zagreb

Poliklinika Borzan ( Site 0500), Osijek, Osjecko-baranjska Zupanija

Institut Klinicke a Experimentalni Mediciny-Klinika hepatogastroentrologie ( Site 0654), Praha, Praha 4

Nemocnice Slany-Gastroenterologicka a Endoskopicka ambulance ( Site 0651), Slany, Stredocesky Kraj

Hepato-Gastroenterologie HK ( Site 0652), Hradec Kralove, Not set

Herlev and Gentofte Hospital ( Site 5300), Copenhagen, Hovedstaden

Odense Universitetshospital ( Site 5301), Odense C, Syddanmark

Tampereen yliopistollinen sairaala ( Site 5401), Tampere, Pirkanmaa

Pohjois-Karjalan Keskussairaala ( Site 5403), Joensuu, Pohjois-Karjala

Turku University Hospital ( Site 5402), Turku, Varsinais-Suomi

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0711), Nice, Alpes-Maritimes

CHU Bordeaux Haut-Leveque ( Site 0713), Pessac, Aquitaine

Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0722), Marseille, Bouches-du-Rhone

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 0708), Dijon, Bourgogne

Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 0707), Reims cedex, Champagne-Ardenne

CHU Besançon ( Site 0724), Besançon, Doubs

Centre Hospitalier de Valence ( Site 0725), Valence, Drome

C.H.U. de Nimes. Hopital Caremeau ( Site 0731), Nimes, Gard

CHU Rangueil ( Site 0710), Toulouse, Haute-Garonne

Hopital Beaujon ( Site 0729), Clichy, Hauts-de-Seine

CMC Ambroise Paré Hartmann - Institut des MICI ( Site 0723), Neuilly-sur-Seine, Hauts-de-Seine

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0702), Kremlin Bicetre, Ile-de-France

CHU SAINT ELOI ( Site 0701), Montpellier, Languedoc-Roussillon

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0705), Nantes, Loire-Atlantique

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 0717), Vandoeuvre-les-Nancy, Meurthe-et-Moselle

Hopital Claude Huriez - CHU de Lille ( Site 0715), Lille, Nord

centre hospitalier lyon sud ( Site 0716), Pierre-Bénite, Rhone

CHU d'Amiens-Picardie - Hôpital Sud ( Site 0709), Amiens, Somme

Hopital Henri Mondor ( Site 0730), Creteil, Val-de-Marne

Hôpital Saint Antoine ( Site 0721), Paris, Not set

LTD High Technology Hospital Medcenter ( Site 0802), Batumi, Ajaria

Caucasus Medical Centre ( Site 0801), Tbilisi, Ajaria

New Hospitals ( Site 0800), Tbilisi, Not set

Caraps Medline ( Site 0803), Tbilisi, Not set

Siloah St. Trudpert Klinikum-Zentrum für Innere Medizin ( Site 0992), Pforzheim, Baden-Wurttemberg

Klinikum der Universität München Großhadern ( Site 0990), München, Bayern

klinikum rechts der isar der technischen universität münchen ( Site 0989), München, Bayern

Universitaetsklinikum Ulm. ( Site 0994), Ulm, Bayern

Universitätsmedizin Rostock ( Site 0993), Rostock, Mecklenburg-Vorpommern

Medizinische Hochschule Hannover ( Site 0999), Hannover, Niedersachsen

Klinikum Lüneburg ( Site 0991), Lüneburg, Niedersachsen

Stadtische Kliniken Duisburg, Abtlg. Innere Medizin ( Site 0985), Duisburg, Nordrhein-Westfalen

Evangelisches Krankenhaus Kalk gGmbH ( Site 0986), Koln, Nordrhein-Westfalen

Gastroenterologische Gemeinschaftspraxis Minden ( Site 0998), Minden, Nordrhein-Westfalen

Medizinisches Versorgungszentrum Portal 10 ( Site 0988), Münster, Nordrhein-Westfalen

Magen Darm Zentrum Remscheid ( Site 0984), Remscheid, Nordrhein-Westfalen

St. Marien und St. Annastift Krankenhaus ( Site 0987), Ludwighafen Am Rhein, Rheinland-Pfalz

Universitätsklinikum Leipzig ( Site 0997), Leipzig, Sachsen

Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0995), Kiel, Schleswig-Holstein

Charité Campus Virchow-Klinikum ( Site 0996), Berlin, Not set

Städtisches Klinikum Brandenburg ( Site 0903), Brandenburg, Not set

Evangelismos General Hospital of Athens ( Site 1002), Athens, Attiki

THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1004), Athens, Attiki

General Hospital of Nikaia-Piraeus "Agios Panteleimon" ( Site 1003), Nikaia Piraeus, Attiki

Ippokrateio General Hospital of Thessaloniki ( Site 1001), Thessaloniki, Kentriki Makedonia

University General Hospital of Heraklion-GASTROENTEROLOGY & HEPATOLOGY ( Site 1000), Heraklion, Kriti

Queen Mary Hospital ( Site 3300), Hksar, Not set

Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-4. Belgyogyaszat Gasztroenterologia ( Site 1105), Békéscsaba, Bekescsaba

Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet ( Site 1117), Eger, Heves

Gyöngyösi Bugát Pál Kórház ( Site 1111), Gyongyos, Heves

Komarom-Esztergom Varmegyei Szent Borbala Korhaz ( Site 1115), Tatabánya, Komarom-Esztergom

VeszLife Magánklinika ( Site 1102), Veszprém, Veszprem

Clinexpert Kft.-Clinexpert Budapest ( Site 1108), Budapest, Not set

Synexus Magyarorszag Kft. (Budapest DRS) ( Site 1107), Budapest, Not set

Pannónia Magánorvosi Centrum ( Site 1103), Budapest, Not set

Emek Medical Center ( Site 1206), Afula, Not set

Barzilai Medical Center ( Site 1209), Ashkelon, Not set

Rambam Health Care Campus ( Site 1201), Haifa, Not set

Bnai Zion Medical Center ( Site 1203), Haifa, Not set

Edith Wolfson Medical Center ( Site 1204), Holon, Not set

Shaare Zedek Medical Center ( Site 1208), Jerusalem, Not set

Meir Medical Center. ( Site 1202), Kfar Saba, Not set

Rabin Medical Center ( Site 1207), Petah Tikva, Not set

Sheba Medical Center ( Site 1200), Ramat Gan, Not set

Policlinico Universitario Monserrato-SC Gastroenterologia ( Site 1313), Monserrato, Cagliari

Fondazione Policlinico Tor Vergata ( Site 1307), Rome, Lazio

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-Gastroenterology and Endoscopy Unit ( Site 1304), Milano, Lombardia

Istituto Clinico Humanitas-IBD center ( Site 1309), Rozzano, Lombardia

A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 1310), Napoles, Napoli

Ospedale "Felice Lotti" Di Pontedera ( Site 1311), Pontedera, Pisa

A.O.U.C. Policlinico di Bari ( Site 1306), Bari, Puglia

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO-U.O.S.D. Malattie Infiammatorie Croniche Intestinali ( Site 1302), Palermo, Sicilia

Ospedale Sacro Cuore Don G. Calabria-IBD Unit ( Site 1303), Negrar Di Valpolicella, Verona

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1308), Bologna, Not set

Azienda Ospedaliera Universitaria Di Messina G. Martino ( Site 1314), Messina, Not set

Ospedale San Raffaele-Gastroenterology and Gastrointestinal Endoscopy ( Site 1300), Milano, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Dipartimento di Medicina Interna e Gas ( Site 1312), Roma, Not set

Aichi Medical University Hospital ( Site 3429), Nagakute, Aichi

Nagoya University Hospital ( Site 3445), Nagoya,, Aichi

Nagoya City University Hospital ( Site 3446), Nagoya, Aichi

Tokatsu Tsujinaka Hospital ( Site 3403), Abiko, Chiba

Tsujinaka Hospital - Kashiwanoha ( Site 3402), Kashiwa, Chiba

Toho University Sakura Medical Center ( Site 3413), Sakura, Chiba

Kurume University Hospital ( Site 3419), Kurume, Fukuoka

Gunma University Hospital ( Site 3432), Maebashi, Gunma

National Hospital Organization Fukuyama Medical Center ( Site 3442), Fukuyama, Hiroshima

Sapporo Tokushukai Hospital ( Site 3427), Sapporo, Hokkaido

Sapporo Medical University Hospital ( Site 3460), Sapporo, Hokkaido

Medical Corporation Sapporo IBD Clinic ( Site 3420), Sapporo, Hokkaido

Sapporohigashi Tokushukai Hospital ( Site 3441), Sapporo, Hokkaido

Hyogo Medical University Hospital ( Site 3430), Nishinomiya, Hyogo

Hitachi General Hospital ( Site 3438), Hitachi, Ibaraki

Kanazawa University Hospital ( Site 3436), Kanazawa, Ishikawa

Iwate Medical University Uchimaru Medical Center ( Site 3457), Morioka, Iwate

Gokeikai Ofuna Chuo Hospital ( Site 3412), Kamakura, Kanagawa

St. Marianna University Hospital ( Site 3440), Kawasaki, Kanagawa

Matsushima Hospital ( Site 3450), Yokohama, Kanagawa

Yokohama City University Medical Center ( Site 3439), Yokohama, Kanagawa

Mie University Hospital ( Site 3405), Tsu, Mie

Tohoku University Hospital ( Site 3447), Sendai, Miyagi

University of the Ryukyus Hospital ( Site 3459), Ginowan, Okinawa

Kansai Medical University Hospital ( Site 3409), Hirakata, Osaka

Saitama Medical Center ( Site 3452), Kawagoe, Saitama

Hamamatsu University Hospital ( Site 3449), Hamamatsu, Shizuoka

Matsuda Hospital ( Site 3404), Hamamatsu, Shizuoka

National Hospital Organization Shizuoka Medical Center ( Site 3401), Shimizu, Shizuoka

Institute of Science Tokyo Hospital ( Site 3437), Bunkyō, Tokyo

Ginza Central Clinic ( Site 3407), Chuo, Tokyo

Kitasato University Kitasato Institute Hospital ( Site 3458), Minato, Tokyo

Kyorin University Hospital ( Site 3443), Mitaka, Tokyo

The Jikei University Hospital ( Site 3414), Mitato, Tokyo

Tokyo Medical University Hospital ( Site 3456), Shinjuku, Tokyo

National Center for Global Health and Medicine ( Site 3423), Shinjuku, Tokyo

Yamanashi Prefectural Central Hospital ( Site 3435), Kofu, Yamanashi

Fukuoka University Hospital ( Site 3417), Fukuoka, Not set

Hiroshima University Hospital ( Site 3418), Hiroshima, Not set

Kagoshima University Hospital ( Site 3425), Kagoshima, Not set

Kagoshima IBD Gastroenterology Clinic ( Site 3428), Kagoshima, Not set

University Hospital,Kyoto Prefectural University of Medicine ( Site 3406), Kyoto, Not set

National Hospital Organization Kyoto Medical Center ( Site 3411), Kyoto, Not set

Okayama University Hospital ( Site 3454), Okayama, Not set

Infusion Clinic ( Site 3408), Osaka, Not set

National Hospital Organization Osaka National Hospital ( Site 3453), Osaka, Not set

Saga University Hospital ( Site 3424), Saga, Not set

Tokyo Yamate Medical Center ( Site 3415), Tokyo, Not set

Toyama Prefectural Central Hospital ( Site 3410), Toyama, Not set

Yamagata University Hospital ( Site 3426), Yamagata, Not set

Wonju Severance Christian Hospital-Internal Medicine ( Site 3600), Wonju, Kang-won-do

The Catholic University Of Korea St. Vincent's Hospital-Gastroenterology ( Site 3608), Suwon-si, Kyonggi-do

Dong-A University Hospital ( Site 3601), Busan, Pusan-Kwangyokshi

Inje University Haeundae Paik Hospital ( Site 3605), Haeundae-gu, Pusan-Kwangyokshi

Chung-Ang University Hospital ( Site 3606), Dongjak-gu, Seoul

Yeungnam Univeristy Medical Center ( Site 3610), Daegu, Taegu-Kwangyokshi

The Catholic University of Korea, Daejeon St. Mary's Hospital ( Site 3604), Daejeon, Taejon-Kwangyokshi

Kyung Hee University Hospital ( Site 3611), Seoul, Not set

Seoul National University Hospital ( Site 3607), Seoul, Not set

Kangbuk Samsung Hospital-Internal Medicine ( Site 3612), Seoul, Not set

The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3602), Seoul, Not set

Severance Hospital, Yonsei University Health System-Department of Internal Medicine ( Site 3603), Seoul, Not set

Asan Medical Center ( Site 3609), Seoul, Not set

Samsung Medical Center ( Site 3613), Seoul, Not set

Hospital of Lithuanian University of Health Sciences Kauno klinikos-Gastroenterology ( Site 6000), Kaunas, Kauno Apskritis

VILNIUS UNIVERSITY HOSPITAL SANTAROS KLINIKOS-Department of Clinical Trials and Pharmacology ( Site 6001), Vilnius, Not set

Hospital Sultanah Aminah ( Site 6104), Johor Bahru, Johor

Hospital Universiti Sains Malaysia ( Site 6103), Kubang Kerian, Kelantan

University Malaya Medical Centre ( Site 6101), Lembah Pantai, Kuala Lumpur

Sarawak General Hospital ( Site 6102), Kuching, Sarawak

Hospital Ampang ( Site 6106), Ampang, Selangor

Centro de Investigación y Gastroenterología - S.C. ( Site 3102), Ciudad de Mexico, Distrito Federal

Morales Vargas Centro de Investigacion ( Site 3101), Leon, Guanajuato

Centro Medico Clinico Quirurgico Especializado en Investigación ( Site 3106), Tlajomulco de Zúñiga, Jalisco

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Gastroenterología ( Site 3100), Monterrey, Nuevo Leon

Servicios de Oncología Médica Integral, S.A de C.V. ( Site 3108), San Pedro Garza Garcia, Nuevo Leon

Centro de Investigacion Clinica de Oaxaca ( Site 3105), Oaxaca de Juarez, Oaxaca

Medical Care and Research SA de CV-GASTROENTEROLOGY ( Site 3110), Merida, Yucatan

Radboudumc ( Site 1505), Nijmegen, Gelderland

ETZ Elisabeth ( Site 1501), Tilburg, Noord-Brabant

Ziekenhuis Bernhoven ( Site 1508), Uden, Noord-Brabant

Amsterdam UMC, locatie VUmc-IBD Trial Unit ( Site 1500), Amsterdam, Noord-Holland

Erasmus Medisch Centrum ( Site 1504), Rotterdam, Zuid-Holland

Franciscus Gasthuis & Vlietland, Locatie Gasthuis ( Site 1503), Rotterdam, Zuid-Holland

University Medical Center Groningen ( Site 1506), Groningen, Not set

Universitair Medisch Centrum Utrecht ( Site 1502), Utrecht, Not set

Dunedin Hospital ( Site 3505), Dunedin, Otago

Hutt Valley District Health board HVDHB ( Site 3500), Lower Hutt, Wellington

Aotearoa Clinical Trials ( Site 3501), Auckland, Not set

Investigaciones Clínicas / Instituto de Ginecología y Reproducción ( Site 3002), Lima, Not set

Hospital Cayetano Heredia ( Site 3003), Lima, Not set

Amicare ( Site 1620), Jelenia Gora, Dolnoslaskie

Planetmed ( Site 1600), Wroclaw, Dolnoslaskie

Melita Medical ( Site 1607), Wroclaw, Dolnoslaskie

EMC Instytut Medyczny SA ( Site 1601), Wroclaw, Dolnoslaskie

Gastromed Sp. z o. o. ( Site 1619), Torun, Kujawsko-pomorskie

Centrum Medyczne Med-Gastr Sp. z o.o. ( Site 1616), Lodz, Lodzkie

AmiCare Sp. z o.o. Sp. k. ( Site 1608), Lodz, Lodzkie

Allmedica ( Site 1602), Nowy Targ, Malopolskie

Centrum Zdrowia MDM ( Site 1618), Warszawa, Mazowieckie

WIP Warsaw IBD Point Profesor Kierkuś ( Site 1622), Warszawa, Mazowieckie

H-T Centrum Medyczne Endoterapia ( Site 1610), Tychy, Slaskie

PL Certus ( Site 1605), Poznan, Wielkopolskie

Pratia Poznań ( Site 1603), Poznań, Wielkopolskie

Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 1612), Szczecin, Zachodniopomorskie

Sonomed Sp. z o. o. ( Site 1617), Szczecin, Zachodniopomorskie

Unidade Local de Saúde do Alto Ave - Hospital Senhora da Oliveira ( Site 1704), Guimaraes, Braga

Unidade Local de Saude do Algarve - Hospital de Portimão ( Site 1700), Portimão, Faro

Unidade Local de Saude da Região de Leiria - Hospital Santo André ( Site 1706), Leiria, Not set

Hospital da Luz Lisboa ( Site 1707), Lisboa, Not set

Hospital dos Lusíadas Lisboa ( Site 1701), Lisboa, Not set

ULSAM - Hospital de Santa Luzia ( Site 1703), Viana do Castelo, Not set

Unidade Local de Saude Dão-Lafões - Hospital de São Teotónio ( Site 1702), Viseu, Not set

MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 1806), Bucharest, Bucuresti

Fundeni Clinical Institute-Gastroenterology and Hepatology Center ( Site 1808), București, Bucuresti

GastroMed ( Site 1809), Cluj-Napoca, Cluj

Spitalul Clinic Judetean Mures-Gastroenterology ( Site 1807), Targu Mures, Mures

ASOCIATIA ONCOHELP ( Site 1805), Timisoara, Timis

S.C. Centrul Medical Medicum SRL-Gastroenterology ( Site 1804), Bucuresti, Not set

Clinical Hospital Center Zvezdara-Gastroenterology and hepatology Department ( Site 1903), Belgrade, Beograd

University Medical Center "Bezanijska kosa"-Gastroenterology and hepatology ( Site 1900), Belgrade, Beograd

General Hospital "Djordje Joanovic" ( Site 1905), Zrenjanin, Srednjebanatski Okrug

Clinical Center Kragujevac ( Site 1904), Kragujevac, Sumadijski Okrug

Singapore General Hospital ( Site 6202), Singapore, Central Singapore

Tan Tock Seng Hospital-Gastroenterology and Hepatology ( Site 6201), Singapore, Central Singapore

Changi General Hospital ( Site 6203), Singapore, South East

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica-Gastroenterologicke oddelenie ( Site 2002), Banska Bystrica, Banskobystricky Kraj

Cliniq s.r.o. ( Site 2001), Bratislava, Bratislavsky Kraj

KM Management ( Site 2000), Nitra, Nitriansky Kraj

GASTRO I ( Site 2004), Presov, Presovsky Kraj

Gastro LM ( Site 2005), Presov, Presovsky Kraj

Wits Clinical Research ( Site 4004), Johannesburg, Gauteng

Panorama Medical Centre ( Site 4001), Cape Town, Western Cape

Spoke Research ( Site 4003), Cape Town, Western Cape

Life Kingsbury Hospital ( Site 4000), Cape Town, Western Cape

Private Practice - Dr. M.N. Rajabally ( Site 4007), Plumstead, Western Cape

Hospital Germans Trias i Pujol ( Site 2101), Badalona, Barcelona

HOSPITAL CLÍNIC DE BARCELONA-ICMDM - Clinical Institute of Digestive and Metabolic Diseases ( Site 2112), Barcelona, Cataluna

Complejo Hospitalario Universitario de Ferrol ( Site 2114), A Coruña, La Coruna

Hospital Universitario Puerta de Hierro ( Site 2102), Majadahonda, Madrid

Hospital Universitario de Torrejón ( Site 2108), Torrejón de Ardoz, Madrid

Hospital Universitario La Paz ( Site 2100), Madrid, Not set

Hospital Montecelo. Complexo Hospitalario de Pontevedra ( Site 2107), Pontevedra, Not set

Hospital Universitario Nuestra Senora de la Candelaria ( Site 2105), Santa Cruz de Tenerife, Not set

HOSPITAL CLINICO DE VALENCIA-MEDICINA DIGESTIVA ( Site 2103), Valencia, Not set

Hospital Universitari i Politecnic La Fe ( Site 2111), Valencia, Not set

Hospital Universitario Miguel Servet ( Site 2104), Zaragoza, Not set

Universitetssjukhuset i Linköping ( Site 5502), Linköping, Ostergotlands Lan

Danderyds Sjukhus ( Site 5501), Danderyd, Stockholms Lan

Karolinska Universitetssjukhuset Solna ( Site 5500), Stockholm, Stockholms Lan

University Hospital Basel-Gastroenterology and Hepatology ( Site 2204), Basel, Basel-Stadt

INTESTO-Gastroenterologische Praxis / Crohn-Colitis Zentrum Bern ( Site 2202), Bern, Berne

Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 2201), St.Gallen, Sankt Gallen

UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 2200), Zürich, Zurich

National Taiwan University BioMedical Park Hospital ( Site 3702), Zhu Bei City, Hsinchu

National Taiwan University Hospital-Internal Medicine ( Site 3700), Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch ( Site 3701), Taoyuan, Not set

Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2300), Ankara, Not set

ANKARA UNIVERSITY IBNI SINA HOSPITAL-Gastroenterology ( Site 2303), Ankara, Not set

Ankara Bilkent Şehir Hastanesi-Gastroenterology ( Site 2301), Ankara, Not set

Antalya Egitim ve Arastırma Hastanesi ( Site 2304), Antalya, Not set

Eskisehir Osmangazi University Faculty of Medicine ( Site 2308), Eskisehir, Not set

Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi ( Site 2306), Istanbul, Not set

Marmara Univetsitesi Pendik Egitim ve Arastirma Hastanesi ( Site 2305), Istanbul, Not set

Ege Universitesi Hastanesi ( Site 2302), İzmir, Not set

Kocaeli University Medical Faculty Hospital ( Site 2309), Kocaeli, Not set

Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 5815), Ivano-Frankivsk, Ivano-Frankivska Oblast

Medical Center of Limited ( Site 5806), Kyiv, Kyivska Oblast

Center of Family Medicine Plus ( Site 5803), Kyiv, Kyivska Oblast

Communal Non-profit Enterprise of Lviv Regional Council "Lviv Regional Clinical Hospital"-proctology ( Site 5809), Lviv, Lvivska Oblast

Limited liability company "Medical center Health Clinic" ( Site 5807), Vinnytsia, Vinnytska Oblast

Clinic of Scientific and Research Institute of Invalid Rehabilitation of VNMU n.a. M.I.Pyrohov ( Site 5812), Vinnytsia, Vinnytska Oblast

Communal Non-Commercial Enterprise "Vinnytsia City Clinical -Clinical Therapeutic Department #1 ( Site 5811), Vinnytsia, Vinnytska Oblast

Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 5814), Vinnytsya, Vinnytska Oblast

Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 5813), Lutsk, Volynska Oblast

Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 5800), Kyiv, Not set

Dobrobut Medical Center ( Site 5801), Kyiv, Not set

Medical Center of Private Enterprise "Sygma" ( Site 5808), Kyiv, Not set

Royal Devon & Exeter Hospital ... ( Site 2407), Exeter, Devon

Doncaster Royal Infirmary ( Site 2401), Doncaster, England

Huddersfield Royal Infirmary ( Site 2409), Huddersfield, England

Whipps Cross University Hospital-Clinical Research Unit ( Site 2404), London, England

University College London Hospital-Clinical Research Facility ( Site 2405), London, London, City Of

The John Radcliffe Hospital ( Site 2406), Oxford, Oxfordshire

Southmead Hospital ( Site 2403), Bristol, South Gloucestershire

Walsall Manor Hospital ( Site 2410), West Midlands, Walsall

Conditions: Crohn's Disease

Learn More ›

A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

NCT06581328

Recruiting

Ulcerative Colitis (UC) and Crohn's Disease (CD) are long-term conditions in the gut that can cause diarrhea, swelling (inflammation), bleeding from the anus, and belly pain. The main aim of this study is to check for how many participants with UC and CD signs and symptoms disappear after 3.5 months (14 weeks) of treatment with Vedolizumab (this is called remission). Participants will be treated with Vedolizumab for approximately 1 year (50 weeks). During the first 1.5 months (6 weeks), partici... Read More

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

07/08/2025

Locations: Woodholme Gastroenterology, Glen Burnie, Maryland +3 locations

Conditions: Ulcerative Colitis, Crohn's Disease

Learn More ›

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

NCT04844606

Recruiting

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits. Additional treatment may be available to participants via a Continued Access Period.

Gender:

ALL

Ages:

Between 2 years and 19 years

Trial Updated:

07/07/2025

Locations: UCSF Medical Center at Mission Bay, San Francisco, California +59 locations

UCSF Medical Center at Mission Bay, San Francisco, California

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University School of Medicine, Atlanta, Georgia

Children's Center for Digestive Health Care, LLC, Atlanta, Georgia

Boston Children's Hospital, Boston, Massachusetts

Massachusetts General Hospital, Waltham, Massachusetts

Icahn School of Medicine at Mount Sinai, New York, New York

Cook Children's Medical Center, Fort Worth, Texas

Pediatric Specialists of Virginia, Fairfax, Virginia

Medizinische Universität Wien, Vienna, Wien

Antwerp University Hospital, Edegem, Antwerpen

UZ Brussel, Brussels, Bruxelles-Capitale, Région De

Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De

UZ Gent, Gent, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams-Brabant

Hospital Universitario Cassiano Antonio de Moraes, Vitoria, Espírito Santo

Universidade Federal de Goias, Goiania, Goiás

Hospital Pequeno Príncipe / Associação Hospitalar de Proteção à Infância, Curitiba, Paraná

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Centro de Pesquisa Sao Lucas, Campinas, São Paulo

Integral Pesquisa e Ensino, Votuporanga, São Paulo

The Hospital for Sick Children, Toronto, Ontario

Hôpital Jeanne de Flandre, Lille, Nord-Pas-de-Calais

CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme

Hôpital Armand Trousseau, Paris, Not set

Hôpital Universitaire Necker Enfants Malades, Paris, Not set

Dr. von Haunersches Kinderspital, Munich, Bayern

HELIOS Klinikum Wuppertal, Wuppertal, Nordrhein-Westfalen

Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz, Rheinland-Pfalz

Schneider Children's Medical Center, Petah-Tikva, HaMerkaz

Yitzhak Shamir Medical Center, Zerifin, HaMerkaz

Rambam Health Care Campus, Haifa, HaTsafon

Shaare Zedek Medical Center, Jerusalem, Yerushalayim

Hadassah Medical Center, Jerusalem, Yerushalayim

AOU Policlinico Umberto I, Roma, Lazio

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Lombardia

Ospedale dei Bambini Vittore Buzzi, Milan, Milano

Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Roma

Azienda Ospedaliera Universitaria Meyer IRCCS, Firenze, Toscana

Ospedale Maggiore Azienda USL di Bologna, Bologna, Not set

Tsujinaka Hospital - Kashiwanoha, Kashiwa, Chiba

Juntendo University Hospital, Bunkyo-ku, Tokyo

Institute of Science Tokyo Hospital, Bunkyō, Tokyo

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

Kyungpook National University Chilgok Hospital, Deagu, Taegu-Kwangyǒkshi

Amsterdam UMC, locatie AMC, Amsterdam, Noord-Holland

Erasmus Medisch Centrum, Rotterdam, Zuid-Holland

Centrum Zdrowia Dziecka w Warszawie, Warsaw, Mazowieckie

Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś, Warszawa, Mazowieckie

Korczowski Bartosz, Gabinet Lekarski, Rzeszów, Podkarpackie

Twoja Przychodnia SCM, Szczecin, Zachodniopomorskie

Centro Hospitalar de Sao Joao - Hospital de Sao Joao, Porto, Not set

Hospital Universitario Reina Sofia, Cordoba, Andalucía

Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona [Barcelona]

Hospital Universitari Parc Tauli, Sabadell, Barcelona [Barcelona]

Hospital Universitari i Politecnic La Fe, València, Not set

Royal London Hospital, London, England

The John Radcliffe Hospital, Oxford, England

Sheffield Children's Hospital, Sheffield, Not set

Conditions: Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease

Learn More ›

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

NCT05509777

Recruiting

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of the mirikizumab study is to evaluate efficacy, safety, tolerability, and how well mirikizumab absorbs into the body of pediatric participants with Crohn's disease. Study periods for the intervention-specific appendix (ISA) will be as follows: * A 12-week induction period * A maintenance period from Week 12 to Week 52, and * A safety follow-up period... Read More

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

07/07/2025

Locations: University of California San Diego, La Jolla, California +82 locations

University of California San Diego, La Jolla, California

Cedars Sinai Medical Center, Los Angeles, California

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University, Atlanta, Georgia

Children's Center for Digestive Health Care, LLC, Atlanta, Georgia

Riley Childrens Hospital, Indianapolis, Indiana

Boston Children's Hospital, Boston, Massachusetts

Atlantic Children's Health--Pediatric Gastroenterology, Morristown, New Jersey

Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC), New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Medical Center/New York Presbyterian, New York, New York

Childrens Medical Center, Dayton, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Cook Children's Medical Center, Fort Worth, Texas

University of Vermont Medical Center, Burlington, Vermont

Seattle Children's Hospital, Seattle, Washington

AKH - Medizinische Universtität Wien, Vienna, Not set

Cliniques universitaires Saint-Luc, Bruxelles, Brussel

UZ Leuven, Leuven, Vlaams-Brabant

Universitair Ziekenhuis Brussel, Brussel, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Integral Pesquisa e Ensino, Votuporanga, Sao Paulo

Hospital PUC-CAMPINAS, Campinas, São Paulo

Hospital Pequeno Príncipe, Curitiba-PR, Not set

Hospital das Clínicas - UFG (Universidade Federal de Goiás), Goiânia, Not set

Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set

NDI - Nucleo de Doenças Infecciosas, Santos Dumont, Not set

Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia

IWK Health Centre, Halifax, Nova Scotia

London Health Sciences Centre (LHSC) - Victoria Hospital, London, Ontario

The Hospital for Sick Children, Toronto, Ontario

Hopital Jeanne de Flandre - CHRU Lille, Lille Cedex, Nord

CHU AMIENS Picardie Site SUD CRC, Amiens, Not set

URC CIC, Paris, Not set

Hôpital Robert Debré - Paris, Paris, Not set

Kaplan Medical Center, Pediatric Gastroenterology Dept., Rehovot, Central Dsitrict Of Israel

Soroka Medical Center, Beer Sheva, Not set

Shamir Medical Center (Assaf Harofeh), Israel, Not set

Shaare Zedek, Jerusalem, Not set

Hadassah University Hospital, Ein Kerem,, Jerusalem, Not set

Schneider Children's Medical Center, Petah Tiqva, Not set

Asst Papa Giovanni Xxiii Bergamo, Bergamo, Not set

Azienda USL di Bologna, Bologna, Not set

SOC Gastroenterologia e Nutrizione - AOU Meyer (Primo Piano Ala OVEST, accettazione DH centralizzato), Firenze, Not set

Ospedale dei Bambini Vittore Buzzi, Milano, Not set

Ospedale Pediatrico Bambino Gesù, Roma, Not set

Gastroenterologia ed epatologia pediatrica (Piano terra della Clinica Pediatrica), Roma, Not set

Hirosaki University Hospital, Hirosaki, Aomori Pref.

Kokikai Tsujinaka Hospital Kashiwanoha, Kashiwa-shi, Chiba-Ken

Kobe University Hospital, Kobe, Hyogo

Yokohama City University Medical Center, Center of IBD, Yokohama-shi, Kanagawa-Ken

Miyagi Children's Hospital, Sendai-shi, Miyagi

Juntendo University Hospital, Bunkyo-ku, Tokyo

National Center for Child Health and Development, Setagaya-ku, Tokyo

Saga University Hospital, Saga, Not set

Kyungpook National University Chilgok Hospital, Daegu, Gyeongsangbuk-do

Samsung Medical Center, Seoul, Korea

Inje University Haeundae Paik Hospital, Busan, Kwangyǒkshi

Seoul National University Hospital, Seoul, Teukbyeolsi [Seoul]

Severance Hospital, Yonsei University Health System, Seoul, Not set

Erasmus Medisch Centrum, Rotterdam, Zuid-Holland

Akershus Universitetssykehus, Nordbyagen, Not set

Oslo University Hospital, Oslo, Not set

Universitetssykehuset Nord-Norge, Tromsø, Not set

St-Olavs Hospital, Trondheim, Not set

Instytut Pomnik-Centrum Zdrowia Dziecka, Warszawa, Masovian

Uniwersytecki Szpital Dziecięcy w Krakowie, Krakow, Not set

Korczowski Bartosz, Gabinet Lekarski, Rzeszow, Not set

Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga), Braga, Not set

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisboa, Not set

Centro Hospitalar de São João, E.P.E., Porto, Not set

Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona

Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona

Hospital Universitario Reina Sofia, Cordoba, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

Royal London Hospital, Whitechapel, Greater London

Great Ormond Street Hospital For Children NHS Foundation Trust, London, London, City Of

Royal Hospital for Children and Young People, Edinburgh, Lothian Region

Oxford University Hospitals NHS trust John Radcliffe hospital, Headington, Oxford

Sheffield Children's Hospital, Sheffield, South Yorkshire

Manchester University NHS Foundation Trust, Manchester, Not set

Conditions: Crohn's Disease

Learn More ›

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

NCT06637631

Recruiting

This is a phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn's Disease (CD). The primary objective of this study is to assess the efficacy of different doses of SAR441566 compared with placebo in participants with moderate to severe CD. This study will include a screening period of 4 weeks (+7 calendar days if needed), followed by the Main Study (MS) treatm... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

07/04/2025

Locations: GI Alliance - Sun City- Site Number : 8400020, Sun City, Arizona +93 locations

GI Alliance - Sun City- Site Number : 8400020, Sun City, Arizona

Connecticut Clinical Research Institute- Site Number : 8400007, Bristol, Connecticut

Novum Research LLC - Site Number : 8400021, Clermont, Florida

Homestead Associates in Research- Site Number : 8400012, Homestead, Florida

Clinical Research of Osceola- Site Number : 8400013, Kissimmee, Florida

Wellness Clinical Research - Miami Lakes - 8181 Northwest 154th Street- Site Number : 8400010, Miami Lakes, Florida

GI Alliance - Glenview- Site Number : 8400015, Glenview, Illinois

Illinois Gastroenterology Group- Site Number : 8400011, Gurnee, Illinois

University of Michigan Health System - Ann Arbor- Site Number : 8400017, Ann Arbor, Michigan

GIA Alliance - Flowood - Site Number : 8400019, Flowood, Mississippi

Vector Clinical Trials- Site Number : 8400001, Las Vegas, Nevada

A1 Clinical Network- Site Number : 8400005, New York, New York

Carolina Digestive Diseases- Site Number : 8400014, Greenville, North Carolina

Frontier Clinical Research - Uniontown- Site Number : 8400009, Uniontown, Pennsylvania

Vitality Digestive Institute Clinical Research- Site Number : 8400003, Katy, Texas

Texas Digestive Disease Consultants - Southlake- Site Number : 8400002, Southlake, Texas

Washington Gastroenterology - Tacoma- Site Number : 8400008, Tacoma, Washington

Investigational Site Number : 0320002, San Miguel de Tucumán, Tucumán

Investigational Site Number : 0320003, Buenos Aires, Not set

Investigational Site Number : 0320005, Buenos Aires, Not set

Investigational Site Number : 0320001, Buenos Aires, Not set

Investigational Site Number : 0360002, Sydney, New South Wales

Investigational Site Number : 0360001, South Brisbane, Queensland

Investigational Site Number : 0360003, Parkville, Victoria

Centro de Pesquisas da Clínica IBIS- Site Number : 0760001, Salvador, Bahia

Hospital Moinhos de Vento- Site Number : 0760006, Porto Alegre, Rio Grande Do Sul

Instituto Ceos- Site Number : 0760002, Porto Alegre, Rio Grande Do Sul

Investigational Site Number : 1000001, Gorna Oryahovitsa, Not set

Investigational Site Number : 1240001, Calgary, Alberta

Investigational Site Number : 1240003, Montreal, Quebec

Investigational Site Number : 1240005, Québec City, Quebec

Investigational Site Number : 1520004, Talcahuano, Biobío

Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago

Investigational Site Number : 1520002, Viña Del Mar, Valparaíso

Investigational Site Number : 1520003, Santiago, Not set

Investigational Site Number : 1560008, Changzhou, Not set

Investigational Site Number : 1560009, Chongqing, Not set

Investigational Site Number : 1560012, Fuzhou, Not set

Investigational Site Number : 1560001, Guangzhou, Not set

Investigational Site Number : 1560002, Guangzhou, Not set

Investigational Site Number : 1560004, Hangzhou, Not set

Investigational Site Number : 1560003, Hangzhou, Not set

Investigational Site Number : 1560007, Hefei, Not set

Investigational Site Number : 1560011, Nanchang, Not set

Investigational Site Number : 1560006, Shanghai, Not set

Investigational Site Number : 1560005, Shanghai, Not set

Investigational Site Number : 1560010, Suzhou, Not set

Investigational Site Number : 1910004, Osijek, Not set

Investigational Site Number : 2030001, Olomouc, Not set

Investigational Site Number : 2500005, Montpellier, Not set

Investigational Site Number : 2500002, Nice, Not set

Investigational Site Number : 2500003, Toulouse Cedex 9, Not set

Investigational Site Number : 2500001, Vandoeuvre-les-nancy, Not set

Investigational Site Number : 2680006, Kutaisi, Not set

Investigational Site Number : 2680003, Tbilisi, Not set

Investigational Site Number : 2680007, Tbilisi, Not set

Investigational Site Number : 2680001, Tbilisi, Not set

Investigational Site Number : 2680005, Tbilisi, Not set

Investigational Site Number : 2680002, Tbilisi, Not set

Investigational Site Number : 2680004, Tbilisi, Not set

Investigational Site Number : 2760004, Berlin, Not set

Investigational Site Number : 2760002, Berlin, Not set

Investigational Site Number : 2760005, Halle, Not set

Investigational Site Number : 3800008, Roma, Lazio

Investigational Site Number : 3800009, Milan, Milano

Investigational Site Number : 3800002, Milan, Milano

Investigational Site Number : 3800004, Rozzano, Milano

Investigational Site Number : 3800001, Padua, Padova

Investigational Site Number : 3800006, Rome, Roma

Investigational Site Number : 3800005, Pisa, Not set

Investigational Site Number : 3920004, Kashiwa, Chiba

Investigational Site Number : 3920001, Sakura, Chiba

Investigational Site Number : 3920006, Sapporo, Hokkaido

Investigational Site Number : 3920010, Sapporo, Hokkaido

Investigational Site Number : 3920007, Sapporo, Hokkaido

Investigational Site Number : 3920008, Morioka, Iwate

Investigational Site Number : 3920019, Takamatsu-shi, Kagawa

Investigational Site Number : 3920020, Nagaoka, Niigata

Investigational Site Number : 3920002, Osaka-shi, Osaka

Investigational Site Number : 3920003, Bunkyo, Tokyo

Investigational Site Number : 3920011, Shinjuku-ku, Tokyo

Investigational Site Number : 3920018, Oita, Not set

Investigational Site Number : 3920012, Wakayama, Not set

Investigational Site Number : 4100002, Haeundae-gu, Busan-gwangyeoksi

Investigational Site Number : 4100003, Daejeon, Daejeon-gwangyeoksi

Investigational Site Number : 4800001, Quatre Bornes, Not set

Investigational Site Number : 5280004, Breda, Not set

Investigational Site Number : 5280002, Nijmegen, Not set

Investigational Site Number : 5280001, Tilburg, Not set

Investigational Site Number : 5280003, Utrecht, Not set

Investigational Site Number : 7240002, Seville, Sevilla

Investigational Site Number : 7920003, Istanbul, Not set

Investigational Site Number : 7920001, Mersin, Not set

Investigational Site Number : 7920002, Zonguldak, Not set

Conditions: Crohn's Disease

Learn More ›

A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

NCT06958536

Recruiting

This is a phase 2b, randomized, double-blind, 3-arm study for the treatment of Crohn's disease. The primary objective of this study is to assess the efficacy of different doses of SAR442970 compared with placebo in participants with moderate to severe Crohn's disease. The total study duration is up to 168 weeks, with a treatment period of up to 158 weeks including an open-label (OL) long-term extension (LTE) period of up to 104 weeks for eligible participants

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

07/03/2025

Locations: Gastro Care Institute - Site Number: 8400001, Lancaster, California +5 locations

Conditions: Crohn's Disease

Learn More ›

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

NCT05923073

Recruiting

The purpose of this study is to evaluate the clinical and endoscopic efficacy of guselkumab in pediatric participants with Crohn's Disease (CD) at the end of maintenance therapy (Week 52) among participants who were in clinical response to guselkumab at Week 12.

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

07/02/2025

Locations: Connecticut Children's Medical Center, Hartford, Connecticut +67 locations

Connecticut Children's Medical Center, Hartford, Connecticut

Emory University, Atlanta, Georgia

Children's Center for Digestive Health Care, Atlanta, Georgia

Riley Hospital for Children, Indianapolis, Indiana

Weill Cornell Medical College - Judith Jaffe Multiple Sclerosis Center, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Medical Center, New York, New York

The Children's Medical Center of Dayton, Dayton, Ohio

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Cook Childrens Medical Center, Fort Worth, Texas

University of Vermont Medical Center, Colchester, Vermont

AKH - Medizinische Universitat Wien, Vienna, Not set

Universitair Ziekenhuis Brussel, Brussels, Not set

Cliniques Universitaires Saint Luc, Bruxelles, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro, Campinas, Not set

Associacao Hospitalar de Protecao a Infancia Dr. Raul Carneiro, Curitiba, Not set

Universidade Federal de Goias - Hospital das Clinicas da UFG, Goiania, Not set

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set

Centro de Ciências e Saúde da Universidade Federal do Espirito Santo-Núcleo de Doenças Infecciosas, Vitória, Not set

INTEGRAL Pesquisa e Ensino, Votuporanga, Not set

Iwk Health Centre, Halifax, Nova Scotia

CHU Amiens-Hopital Nord, Amiens Cedex 1, Not set

Hôpital Jeanne de FLANDRE, CHRU LILLE, Lille, Not set

Hôpital Necker - Enfants Malades, Paris cedex 15, Not set

Hôpital Robert Debré, Paris, Not set

Shamir Medical Center Assaf Harofeh, Be Er Ya Akov, Not set

Soroka University Medical Center, Beersheba, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Hadassah Medical Center, Jerusalem, Not set

Schneider Children's Medical Center, Petach-Tikva, Not set

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo, Not set

Ospedale Bellaria, U.O.Cardiologia Az. USL di Bologna, Bologna, Not set

Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer, Firenze, Not set

Azienda Socio Sanitaria Territoriale Fatebenefratelli Presidio Ospedale dei Bambini Vittore Buzzi, Milano, Not set

AOU Policlinico Umberto I, Roma, Not set

Hirosaki University Hospital, Hirosaki, Not set

Tsujinaka Hospital Kashiwanoha, Kashiwa-shi, Not set

Saga University Hospital, Saga, Not set

Miyagi Children's Hospital, Sendai, Not set

National Center for Child Health and Development, Setagaya Ku, Not set

Juntendo University Hospital, Tokyo, Not set

Yokohama City University Medical Center, Yokohama-shi, Not set

Inje University Haeundae Paik Hospital, Busan, Not set

Kyungpook National University Chilgok Hospital, Daegu, Not set

Seoul National University Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Severance Hospital Yonsei University Health System, Seoul, Not set

Erasmus Medisch Centrum, Rotterdam, Not set

Akershus Universitetssykehus HF, Nordbyhagen, Not set

Oslo University Hospital, Oslo, Not set

Universitetssykehuset Nord-Norge HF, Tromsø, Not set

St. Olavs Hospital, Trondheim, Not set

Korczowski Bartosz Gabinet Lekarski, Rzeszow, Not set

WIP Warsaw IBD Point Profesor Kierkus, Warszawa, Not set

Instytut Pomnik Centrum Zdrowia, Warszawa, Not set

Hospital de Braga, Braga, Not set

Centro Hospitalar de Lisboa Norte Hospital Santa Maria, Lisboa, Not set

Centro Hospitalar de Sao Joao E.P.E., Porto, Not set

Hosp Reina Sofia, Córdoba, Not set

Corporacio Sanitari Parc Tauli, Sabadell, Not set

Hosp. Univ. I Politecni La Fe, Valencia, Not set

Royal Hospital for Sick Children, Glasgow, Not set

Great Ormond Street Hospital, London, Not set

Nowgen Centre, Research and Innovation, Manchester, Not set

Royal Manchester Children's Hospital, Manchester, Not set

John Radcliffe Hospital, Oxford, Not set

Sheffield Children's Hospital, Sheffield, Not set

Conditions: Crohn's Disease

Learn More ›

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

NCT06937099

Recruiting

The main purpose of this study is to evaluate the efficacy and safety of mirikizumab and placebo compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and obesity, or overweight. The maximum duration of this study is up to 61 weeks.

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

07/02/2025

Locations: Digestive Health Specialists, Dothan, Alabama +190 locations

Digestive Health Specialists, Dothan, Alabama

Smart Cures Clinical Research, Anaheim, California

Cedars-Sinai Medical Center, Beverly Hills, California

United Medical Doctors - Los Alamitos, Los Alamitos, California

California Medical Research Associates, Northridge, California

Research Associates of South Florida - Miami - Southwest 8th Street, Miami, Florida

Gastro Health Research - Miami, Miami, Florida

Orlando Health, Orlando, Florida

Digestive and Liver Center of Florida, Orlando, Florida

Gastro Health Research - Pensacola, Pensacola, Florida

Precision Clinical Research, Sunrise, Florida

Grand Teton Research Group, Idaho Falls, Idaho

Rush University Medical Center, Chicago, Illinois

Indiana University Health University Hospital, Indianapolis, Indiana

Gastroenterology Health Partners, New Albany, Indiana

Gastroenterology Health Partners, Louisville, Kentucky

Care Access - New Iberia, New Iberia, Louisiana

Louisiana Research Center, Shreveport, Louisiana

Capital Digestive Care - Chevy Chase, Chevy Chase, Maryland

Lucida Clinical Trials, New Bedford, Massachusetts

Washington University School of Medicine, Saint Louis, Missouri

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

New York Gastroenterology Associates, New York, New York

Care Access - Yonkers, Yonkers, New York

Coastal Research Institute - Fayetteville, Fayetteville, North Carolina

Gastro Intestinal Research Institute of Northern Ohio, LLC, Westlake, Ohio

Thomas Jefferson University - Medicine/GI and Hepatology, Philadelphia, Pennsylvania

University Gastroenterology - Providence - West River Street, Providence, Rhode Island

Gastroenterology Associates - Patewood, Greenville, South Carolina

Gastroenterology Center Of The Midsouth, Cordova, Tennessee

Caprock Gastro Research, Lubbock, Texas

Gastroenterology Research of San Antonio, San Antonio, Texas

Southern Star Research Institute, San Antonio, Texas

Tyler Research Institute, Tyler, Texas

Washington Gastroenterology - Tacoma, Tacoma, Washington

Wisconsin Center for Advanced Research, Milwaukee, Wisconsin

Medizinische Universität Graz, Graz, Steiermark

Medizinische Universitaet Innsbruck, Innsbruck, Tirol

Medizinische Universität Wien, Vienna, Wien

Université Libre de Bruxelles - Hôpital Erasme, Brussels, Bruxelles-Capitale, Région De

Clinical Chc Montlégia, Liege, Liège

AZORG Campus Aalst-Moorselbaan, Aalst, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams-Brabant

AZ Groeninge Campus Kennedylaan, Kortrijk, West-Vlaanderen

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set

CLIAGEN Clínica de Atenção em Gastroenterologia, Especialidades e Nutrição, Salvador, Bahia

L2IP - Instituto de Pesquisas Clínicas, Brasília, Distrito Federal

CEDOES, Vitória, Espírito Santo

Galileo Medical Research, Juiz de Fora, Minas Gerais

Centro Digestivo de Curitiba, Curitiba, Paraná

Fundação Universidade de Caxias do Sul (FUCS), Caxias do sul, Rio Grande Do Sul

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

NewData Clinical Research - Aracaju, Aracaju, Sergipe

Loema Instituto de Pesquisa Clinica, Campinas, São Paulo

Hospital de Clínicas de Ribeirão Preto, Ribeirão Preto, São Paulo

Pesquisare Saude, Santo André, São Paulo

Integral Pesquisa e Ensino, Votuporanga, São Paulo

CPQuali Pesquisa Clínica, São Paulo, Not set

CEPIC - Centro Paulista de Investigação Clínica, São Paulo, Not set

Clínica Hepatogastro JK, São Paulo, Not set

University Hospital "St. Ivan Rilski", Gorna Oryahovitsa, Veliko Tarnovo

University Multiprofile Hospital for Active Treatment "Tsaritsa Yoanna-ISUL" EAD, Sofia, Not set

Gastroenterology and internal medicine research institute, Edmonton, Alberta

Vancouver General Hospital, Vancouver, British Columbia

(G.I.R.I.) GI Research Institute Foundation, Vancouver, British Columbia

Victoria Hospital & Children's Hospital - London Health Sciences Centre, London, Ontario

London Digestive Disease Institute, London, Ontario

Clinique IMD, Montreal, Quebec

Poliklinika Solmed, Zagreb, Grad Zagreb

SurGal Clinic, Brno, Brno-město

Nemocnice České Budějovice, České Budějovice, Jihočeský Kraj

Krajská nemocnice Liberec, Turnov, Liberecký Kraj

EndoArt, Ostrava, Moravskoslezský Kraj

ResTrial GastroEndo s.r.o, Prague, Praha 4

ISCARE klinické centrum, Prague, Praha 9

Gastroenterologie, Hradec Králové, Not set

Masarykova Nemocnice V Usti Nad Labem, Usti nad Labem, Ústí Nad Labem

Rigshospitalet, Copenhagen, Hovedstaden

Herlev and Gentofte Hospital, Copenhagen, Hovedstaden

Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland

Aalborg Universitetshospital, Syd, Aalborg, Nordjylland

Vejle Sygehus, Vejle, Syddanmark

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Alpes-Maritimes

Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Bouches-du-Rhône

CHU Rangueil, Toulouse cedex 9, Haute-Garonne

Clinique Pasteur, Toulouse, Haute-Garonne

CHU Charles Nicolle, Rouen, Haute-Normandie

Centres Médico Chirurgicaux - Clinique Ambroise Paré, Neuilly-sur-Seine, Hauts-de-Seine

Clinique des Cèdres, Échirolles, Isère

Chu Saint Eloi, Montpellier, Languedoc-Roussillon

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre, Le Kremlin-Bicêtre, Paris

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, Paris

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes, Pays-de-la-Loire

Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord, Saint-Priest-en-Jarez, Rhône-Alpes

CHD Vendee, La Roche-sur-Yon, Vendée

Hôpital Saint Antoine, Paris, Not set

Klinikum Ernst von Bergmann, Potsdam, Brandenburg

Universitätsklinikum Frankfurt Goethe-Universität, Frankfurt, Hessen

Medizinische Hochschule Hannover, Hannover, Niedersachsen

Praxiszentrum für Gastroenterologie, Grevenbroich, Nordrhein-Westfalen

Studiengesellschaft BSF Unternehmergesellschaft, Halle (Saale), Sachsen-Anhalt

Eugastro GmbH, Leipzig, Sachsen

Evangelismos General Hospital of Athens, Athens, Attikí

Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí

University Hospital of Ioannina, Ioannina, Ioánnina

Ippokrateio General Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía

University General Hospital of Heraklion, Heraklion, Krítí

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged, Csongrád

CLINFAN Szolgáltató Kft, Szekszárd, Tolna

Semmelweis Egyetem, Budapest, Not set

Assuta Ashdod Medical Center, Ashdod, HaDarom

Edith Wolfson Medical Center, Holon, HaMerkaz

Rabin Medical Center, Petah Tikva, HaMerkaz

Sheba Medical Center, Ramat Gan, HaMerkaz

Yitzhak Shamir Medical Center, Zerifin, HaMerkaz

Rambam Health Care Campus, Haifa, HaTsafon

Sourasky Medical Center, Tel Aviv, Tell Abīb

Shaare Zedek Medical Center, Jerusalem, Yerushalayim

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Emilia-Romagna

Fondazione Policlinico Universitario Agostino Gemelli, Roma, Lazio

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Lombardia

Humanitas, Rozzano, Lombardia

Ospedale Di Circolo, Rho, Milano

Ospedale Specializzato in Gastroenterologia "Saverio de Bellis", Castellana Grotte, Puglia

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicilia

Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana

Azienda Ospedale - Università Padova, Padova, Veneto

Ospedale San Raffaele, Milano, Not set

Boca Clinical Trials Mexico S.C., Guadajalara, Jalisco

Centro de Investigación Clínica y Medicina Traslacional (CIMeT), Guadalajara, Jalisco

Hospital General de Occidente, Guadalajara, Jalisco

Centro de Investigacion Clinica Chapultepec, Morelia, Michoacán

Servicios de Oncología Médica Integral - Monterrey, Monterrey, Nuevo León

Health Pharma Querétaro, Juriquilla, Querétaro

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C., Ciudad Madero, Tamaulipas

Medical Care and Research SA de CV, Merida, Yucatán

San Peregrino Unidad de Investigación, Aguascalientes, Not set

Scientia Investigacion Clinica S.C., Chihuahua, Not set

Instituto de Investigaciones Aplicadas a la Neurociencia A.C., Durango, Not set

Centro de Investigación Clinica Chapultepec, Mexico City, Not set

Boca Clinical Trials Mexico SC, Puebla, Not set

Clinical Research Institute S.C., Tlalnepantla de Baz, Not set

FAICIC S. de R.L. de C.V., Veracruz, Not set

Radboudumc, Nijmegen, Gelderland

Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland

Erasmus Medisch Centrum, Rotterdam, Zuid-Holland

Ikazia Ziekenhuis, Rotterdam, Zuid-Holland

Universitair Medisch Centrum Utrecht, Utrecht, Not set

Melita Medical, Wroclaw, Dolnośląskie

Medrise Sp. z o.o., Lublin, Lubelskie

ETG Zamość, Zamość, Lubelskie

NZOZ GynCentrum - Oddział Warszawa, Warsaw, Mazowieckie

Vivamed Sp. z o.o., Warszawa, Mazowieckie

Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś, Warszawa, Mazowieckie

Korczowski Bartosz, Gabinet Lekarski, Rzeszów, Podkarpackie

Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty, Bialystok, Podlaskie

Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej, Poznan, Wielkopolskie

Twoja Przychodnia PCM, Poznań, Wielkopolskie

Twoja Przychodnia SCM, Szczecin, Zachodniopomorskie

IRMED, Piotrkow Trybunalski, Łódzkie

Caribbean Medical Research Center, San Juan, Not set

Spitalul Județean de Urgență Bacău, Bacau, Bacău

Spitalul Clinic Colentina, Bucuresti, București

Constanta County Emergency Clinical Hospital Sf.Ap.Andrei, Constanta, Constanța

Spitalul Clinic Județean de Urgență, Craiova, Dolj

S.C Centrul de Gastroenterologie Dr. Goldis S.R.L, Timisoara, Timiș

Spitalul Universitar de Urgență București, București, Not set

University Medical Center "Bezanijska kosa", Belgrade, Beograd

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Banskobystrický Kraj

Cliniq s.r.o., Bratislava, Bratislavský Kraj

ENDOMED, Kosice, Košický Kraj

Gastro LM, Presov, Not set

Hospital de Cabueñes, Gijón, Asturias

Hospital Universitario Central de Asturias, Oviedo, Asturias

Centro Médico Teknon, Barcelona, Barcelona [Barcelona]

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Galdakao-Usansolo, Galdakao, Bizkaia

Complejo Hospitalario de Navarra, Pamplona, Navarra

Hospital General Universitario Gregorio Marañon, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

Antalya Egitim ve Arastırma Hastanesi, Muratpasa, Antalya

Eskisehir Osmangazi University, Eskisehir, Eskişehir

Kocaeli University Medical Faculty Hospital, Izmit, Kocaeli

Uludag Universitesi, Bursa, Not set

Mustafa Kemal Universitesi, Hatay, Not set

Bezmialem Vakf Üniversitesi, Istanbul, Not set

Ege Universitesi Hastanesi, İzmir, Not set

Mersin University, Mersin, Not set

Conditions: Crohn's Disease, Obesity or Overweight

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

NCT06332534

Recruiting

Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most often affecting the bowels. It can cause many different symptoms including abdominal pain, diarrhea, tiredness, and weight loss. This study will assess how safe and effective oral Upadacitinib is in treating moderately to severely active Crohn's Disease in pediatric participants aged 2 to 18 years old who have had inadequate response, loss of response, intolerance, or medical contraindications to corticosteroids, immunosuppressants, and/or biologic therapy. Upadacitinib (RINVOQ) is a drug approved in adults for moderate- to severely active CD and is being developed for moderate- to severely active CD in pediatric participants. This study is conducted in 2 periods: Period 1 is comprised of two phases: a 12-week open-label induction phase which means that the study doctor and participants know that participants will receive UPA Dose-A (or the adult equivalent based on body weight) followed by a 52-week double-blind maintenance phase meaning that neither the participants nor the study doctors will know which dose of upadacitinib will be given(UPA Dose B or Dose C). Period 2 is a 156-week open-label extension of Period 1. Approximately 110 pediatric participants with moderate to severely active CD will be enrolled at approximately 92 sites worldwide. Participants will receive upadacitinib oral tablets once daily or oral solution twice daily at approximately the same time each day, with or without food. Participants will have a safety follow up for 30 days after discontinuation from any time point within the study. There may be higher treatment burden for participants in this trial compared to their standard of care (due to study procedures). Participants will attend regular (weekly, monthly) visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires. Read Less

Gender:

ALL

Ages:

Between 2 years and 17 years

Trial Updated:

07/01/2025

Locations: UCSF Benioff Children's Hospital - Oakland /ID# 262217, Oakland, California +74 locations

UCSF Benioff Children's Hospital - Oakland /ID# 262217, Oakland, California

Children's Hospital Colorado - Aurora /ID# 262207, Aurora, Colorado

Connecticut Children's Medical Center - Hartford /ID# 262256, Hartford, Connecticut

OSF St. Francis Medical Center /ID# 262192, Peoria, Illinois

Indiana University Health Riley Hospital for Children /ID# 262215, Indianapolis, Indiana

MNGI Digestive Health, P. A. /ID# 262204, Minneapolis, Minnesota

Icahn School of Medicine at Mount Sinai /ID# 262216, New York, New York

Univ NC Chapel Hill /ID# 262198, Chapel Hill, North Carolina

UH Cleveland Medical Center /ID# 262188, Cleveland, Ohio

Children's Hospital of Philadelphia - Main /ID# 262197, Philadelphia, Pennsylvania

Sydney Children's Hospital /ID# 262352, Randwick, New South Wales

Children's Hospital at Westmead /ID# 262350, Westmead, New South Wales

Queensland Children's Hospital /ID# 262351, South Brisbane, Queensland

Monash Health - Monash Medical Centre /ID# 262878, Clayton, Victoria

Perth Children'S Hospital /ID# 272905, Perth, Western Australia

Uza /Id# 261745, Edegem, Antwerpen

Cliniques Universitaires UCL Saint-Luc /ID# 261741, Bruxelles, Bruxelles-Capitale

Universitair Ziekenhuis Leuven /ID# 261740, Leuven, Vlaams-Brabant

Hospital Universite Enfants Reine Fabiola /ID# 261744, Bruxelles, Not set

CHR de la Citadelle /ID# 261749, Liege, Not set

UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 261750, Namur, Not set

Galileo Medical Research Ltda /ID# 262602, Juiz de Fora, Minas Gerais

Hospital Pequeno Príncipe /ID# 262600, Curitiba, Parana

Irmandade da Santa Casa de Misericordia de Porto Alegre /ID# 262601, Porto Alegre, Rio Grande Do Sul

Hospital Sírio Libanês /ID# 262670, São Paulo, Sao Paulo

Rocco & Nazato Servicos Medicos /ID# 262485, São Paulo, Sao Paulo

UMHAT Sveti Georgi /ID# 262590, Plovdiv, Not set

Specialized Hospital For Active Treatment Of Children Diseases Prof. Ivan Mitev /ID# 262589, Sofiya, Not set

Beijing Children's Hospital /ID# 262258, Beijing, Beijing

Guangzhou Medical University Affiliated Women and Children's Medical Center /ID# 262596, Guangzhou, Guangdong

The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 272807, Guangzhou, Guangdong

Henan Children's Hospital Zhengzhou Children's Hospital /ID# 262300, Zhengzhou, Henan

Hunan Children's Hospital /ID# 262512, Changsha, Hunan

Shengjing Hospital of China Medical University /ID# 262301, Shenyang, Liaoning

Children's Hospital of Shanghai /ID# 262356, Shanghai, Shanghai

Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 262502, Shanghai, Shanghai

Hospices Civils de Lyon - Hôpital Femme Mère Enfant /ID# 263422, Bron CEDEX, Rhone

CHU de CAEN - Hopital de la Cote de Nacre /ID# 262311, Caen, Not set

Hopitaux de Paris (AP-HP) - Hopital Robert Debre - CHU /ID# 262308, Paris, Not set

Agia Sofia Hospital /ID# 261792, Athens, Attiki

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 261790, Athens, Attiki

University General Hospital of Heraklion PA.G.N.I /ID# 261791, Heraklion, Kriti

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 262384, San Giovanni Rotondo, Foggia

Azienda Ospedaliera Universitaria Gaetano Martino /ID# 262380, Messina, Not set

Tsujinaka Hospital Kashiwanoha /ID# 262454, Kashiwa-shi, Chiba

Kurume University Hospital /ID# 262455, Kurume-shi, Fukuoka

Miyagi Children's Hospital /ID# 262459, Sendai-shi, Miyagi

Osaka Women's and Children's Hospital /ID# 262549, Izumi-Shi, Osaka

Saga University Hospital /ID# 262753, Saga-shi, Saga

Saitama Children's Medical Center /ID# 262461, Saitama-shi, Saitama

Institute of Science Tokyo Hospital /ID# 262510, Bunkyo-ku, Tokyo

Tokyo Metropolitan Children's Medical Center /ID# 262550, Fuchu-shi, Tokyo

National Center for Child Health and Development /ID# 262456, Setagaya-ku, Tokyo

Toyama Prefectural Central Hospital /ID# 262739, Toyama-shi, Toyama

Seoul National University Hospital /ID# 262324, Seoul, Seoul Teugbyeolsi

Yonsei University Health System Severance Hospital /ID# 262721, Seoul, Seoul Teugbyeolsi

Samsung Medical Center /ID# 262323, Seoul, Seoul Teugbyeolsi

Christchurch Hospital /ID# 262577, Christchurch, Canterbury

Starship Child Health /ID# 262576, Auckland, Not set

Gastromed Sp. z o.o /ID# 262367, Torun, Kujawsko-pomorskie

Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 262366, Warszawa, Mazowieckie

Clinical Research Investigator Group, LLC /ID# 262357, Bayamon, Not set

Puerto Rico Health Institute /ID# 262358, Dorado, Not set

Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 262226, Ferrol, A Coruna

Hospital Sant Joan de Deu /ID# 262599, Esplugues de Llobregat, Barcelona

Hospital Regional Universitario de Malaga /ID# 262228, Malaga, Not set

Hospital Universitario Virgen del Rocio /ID# 262712, Sevilla, Not set

Hospital Clinico Universitario Lozano Blesa /ID# 262227, Zaragoza, Not set

National Taiwan University Hospital /ID# 261695, Taipei City, Taipei

Linkou Chang Gung Memorial Hospital /ID# 261696, Taoyuan City, Not set

Addenbrooke's Hospital /ID# 262707, Cambridge, Cambridgeshire

Sheffield Children's Hospital NHS Foundation Trust /ID# 261832, Sheffield, England

Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 262811, London, Greater London

Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 262778, Norwich, Norfolk

Royal Hospital for Children and Young People /ID# 262388, Edinburgh, Not set

Conditions: Crohn's Disease

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