There are currently 2694 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Cardiac Sarcoidosis Randomized Trial
NCT03593759
Recruiting
Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in significantly better quality of life and less toxicity than sta... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Cardiac Sarcoidosis, Sarcoidosis
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DNA Analysis of Blood and Tissue from Patients with Lung Cancer
NCT00471978
Recruiting
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is analyzing the DNA in blood and tissue samples from patients with lung cancer.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
11/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Lung Cancer
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A Prospective, Observational Study in Adults With Retinitis Pigmentosa (RP)
NCT06517940
Recruiting
The natural history in individuals with severe retinitis pigmentosa (RP) is variable and there remains an unmet need to better understand disease progression in this population. The goal of this study is to determine which visual assessments individuals with RP and low visual acuity can reliably perform and to evaluate the annual decline of visual function in severe RP.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Mass Eye and Ear, Boston, Massachusetts
Conditions: Retinitis Pigmentosa
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Molecular and Genetic Analysis of Lung Cancer
NCT03029325
Recruiting
Investigators use a genome-wide approach within a case-control design to identify SNPs that show evidence of association with lung cancer risk and survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer
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A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis
NCT06431373
Recruiting
The purpose of this study is to determine the safety and efficacy of brepocitinib in participants with active, non-anterior (intermediate, posterior, or pan) non-infectious uveitis (NIU).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/25/2024
Locations: Clinical Trial Site, Boston, Massachusetts
Conditions: Uveitis, Posterior, Uveitis, Intermediate, Uveitis
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Telemedicine Intervention in Patients With Chronic Pain in PD
NCT05410392
Recruiting
Pain is a very common and disabling symptom in Parkinson's disease, yet it is often untreated. This study will assess the impact of home-based physical and cognitive exercise interventions to reduce pain in this disease. This approach would offer an easily implemented and affordable way to encourage and maintain use of these interventions by patients virtually indefinitely through remote access technology. The study findings may help VA clinicians provide optimal care for the many Veterans with... Read More
Gender:
ALL
Ages:
Between 40 years and 89 years
Trial Updated:
11/25/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Parkinson's Disease
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KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children with Intestinal Failure
NCT05879835
Recruiting
A multi-site, randomized, 2-arm open-label trial to determine if 4% Tetrasodium (EDTA) catheter lock solution is more effective than heparin lock (standard of care) in preventing central venous catheter occlusions in children with intestinal failure (IF) on total parenteral nutrition (TPN).
Gender:
ALL
Ages:
Between 4 weeks and 18 years
Trial Updated:
11/25/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pediatric Intestinal Failure
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Skilled Nursing Facility Care At Home
NCT06416670
Recruiting
We will perform a parallel-group multicenter patient-level randomized controlled evaluation of skilled nursing facility care at home. Patients typically referred to a skilled nursing facility following hospitalization will be eligible for enrollment. Instead of admission to a skilled nursing facility, participants will receive care from a technology-enabled team in their own homes or will be allocated to receive care in a traditional skilled nursing facility setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +3 locations
Conditions: Skilled Nursing Facility, Rehabilitation
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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
NCT06201416
Recruiting
This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/25/2024
Locations: Tufts University, Boston, Massachusetts +2 locations
Conditions: Rheumatoid Arthritis
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Avelumab and M1774 in ARID1A-mutated Endometrial Cancer (Prior IO)
NCT06518564
Recruiting
The purpose of this research study is to see if the combination of study drugs avelumab and M1774 is effective and safe for participants with endometrial cancer. The names of the study drugs involved in this study are: * Avelumab (a type of human IgG1 antibody) * M1774 (a type of ATR inhibitor)
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +1 locations
Conditions: Endometrial Cancer, ARID1A Gene Mutation, Recurrent Endometrial Carcinoma
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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
NCT04916210
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
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Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
NCT04523194
Recruiting
The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.
Gender:
ALL
Ages:
All
Trial Updated:
11/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis
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