There are currently 2699 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Psychoeducational Intervention for Patients With Hepatocellular Carcinoma
NCT06541990
Recruiting
This study aims to refine and pilot test HARMONY, a psychoeducational intervention for patients with newly diagnosed hepatocellular carcinoma (HCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hepatocellular Carcinoma, Cirrhosis
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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
NCT04065399
Recruiting
Phase 1 dose escalation will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of revumenib in participants with acute leukemia. In Phase 2, participants will be enrolled in 3 indication-specific expansion cohorts to determine the efficacy, short- and long-term safety, and tolerability of revumenib.
Gender:
ALL
Ages:
30 days and above
Trial Updated:
11/19/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage
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Genome Environment Microbiome and Metabolome in Autism Study
NCT04271774
Recruiting
GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and possible solutions for alleviating and/or preventing ASD and ASD-related symptoms in pat... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital for Children, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
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Brain-Computer Interfaces in Laryngeal Dystonia
NCT04421365
Recruiting
The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Laryngeal Dystonia
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Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
NCT05150106
Recruiting
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear and University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
NCT05150093
Recruiting
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, University of California San Francisco, University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
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Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
NCT05216770
Recruiting
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear and University of California San Francisco, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
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Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
NCT05317390
Recruiting
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor, Dyskinesias, Myoclonus, Tic Disorders, Torticollis, Ulnar Nerve Entrapment, Temporomandibular Joint Disorders, Dysphonia
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Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928
Recruiting
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +3 locations
Conditions: Myocarditis Acute, Cancer
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Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)
NCT06029244
Recruiting
The purpose of this research is to investigate whether addition of the EyeControl-Pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium incidence and severity.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/19/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
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Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
NCT06088758
Recruiting
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Brigham, Boston, Massachusetts
Conditions: Liver Transplant
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Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person Vs. ONline
NCT06432790
Recruiting
The goal of this study is to evaluate the effectiveness of CHAMPION ("Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline"), a primary care-based intervention to address childhood obesity and asthma, and test the effectiveness of a telehealth-only version of the program. Intensive Health Behavior and Lifestyle Treatment (IHBLT), when delivered via telehealth vs. in-person among children with overweight or obesity and persistent asthma.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Overweight, Childhood, Obesity, Childhood, Asthma in Children
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