There are currently 2699 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
NCT05317390
Recruiting
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor, Dyskinesias, Myoclonus, Tic Disorders, Torticollis, Ulnar Nerve Entrapment, Temporomandibular Joint Disorders, Dysphonia
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Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928
Recruiting
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +3 locations
Conditions: Myocarditis Acute, Cancer
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Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)
NCT06029244
Recruiting
The purpose of this research is to investigate whether addition of the EyeControl-Pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium incidence and severity.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/19/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
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Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
NCT06088758
Recruiting
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Brigham, Boston, Massachusetts
Conditions: Liver Transplant
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Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person Vs. ONline
NCT06432790
Recruiting
The goal of this study is to evaluate the effectiveness of CHAMPION ("Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline"), a primary care-based intervention to address childhood obesity and asthma, and test the effectiveness of a telehealth-only version of the program. Intensive Health Behavior and Lifestyle Treatment (IHBLT), when delivered via telehealth vs. in-person among children with overweight or obesity and persistent asthma.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Overweight, Childhood, Obesity, Childhood, Asthma in Children
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Guideline Directed Medical Therapy in Patients with Heart Failure
NCT06700213
Recruiting
The TEAM-MGH study will formerly evaluate impact of the GDMT Clinic versus matched usual care patients on the proportion of GDMT administration over a 12 week period in approximately 300 total patients with HF across the spectrum of LVEF (with a minimum of 150 with HFrEF). The study will also assess impact of the GDMT Clinic on health status, functional capacity, biomarker profiles, cardiac remodeling and cardiovascular events.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Heart Failure
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Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU
NCT06116110
Recruiting
This is an observational long-term follow-up (LTFU) study for subjects who previously received zamtocabtagene autoleucel, known as MB-CART2019.1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Non Hodgkin Lymphoma
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Optimal Stimulation Parameters to Disrupt Epileptiform Activity
NCT06141668
Recruiting
Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.
Gender:
ALL
Ages:
All
Trial Updated:
11/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Refractory Epilepsy
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Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
NCT06247098
Recruiting
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Tufts University School of Dental Medicine, Boston, Massachusetts
Conditions: Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
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Language During Inhalational Induction
NCT06324955
Recruiting
The aim of this study is to compare the impact of common (standard of care) language vs positive language used by clinicians during inhalational induction of anesthesia on anxiety and negative behaviors in children. This is a prospective randomized parallel group trial. Patients will be randomized 1:1 to the common/standard language group or the positive language group.
Gender:
ALL
Ages:
Between 5 years and 10 years
Trial Updated:
11/18/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Emergence Delirium, Anesthesia; Adverse Effect
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Web-administered STAIR for Patients on Behavioral Health Waitlists
NCT06431022
Recruiting
Posttraumatic stress disorder (PTSD) is a significant public health challenge with population prevalence rates in the US between 6.1 to 9.2%. There are large racial and socioeconomic inequities in access to PTSD treatment, as up to half (30-50%) of patients in safety net clinical settings meet criteria for PTSD, yet only 13% receive any behavioral health treatment. Workforce shortages are one major barrier to accessing care. Additional barriers to care can include heightened mental health stigma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Post Traumatic Stress Disorder
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Employment Support After Hematopoietic Stem Cell Transplantation
NCT06494423
Recruiting
This is a feasibility study of a Work Support (WorkS) intervention designed to ameliorate employment challenges for people preparing to return to work after allogeneic stem cell transplantation. The aim of this study is to evaluate "proof of concept" by: 1. examining the feasibility and acceptability of the WorkS intervention and the study procedures, and 2. exploring the preliminary effects of WorkS for improving patient-reported return-to-work self-efficacy, work status, quality of life, and... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/18/2024
Locations: MGH Cancer Center, Boston, Massachusetts
Conditions: Hematopoietic Stem Cell Transplantation
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