There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms
Recruiting
The purpose of this research study is to test the safety of a new three drug combination of navitoclax, decitabine, and venetoclax to treat advanced myeloid malignancies. The names of the drugs involved in this study are: Venetoclax Decitabine Navitoclax
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +2 locations
Conditions: Myeloid Malignancy, Myelodysplastic Syndromes, Myelofibrosis, Acute Myeloid Leukemia, Myeloproliferative Neoplasm
Cardiac Sarcoidosis Randomized Trial
Recruiting
Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in significantly better quality of life and less toxicity than sta... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/24/2023
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Cardiac Sarcoidosis, Sarcoidosis
Advanced Fetal Imaging - Phase II
Recruiting
The goal of Advanced Fetal Imaging - Phase II is to advance fetal MRI imaging by designing MRI coils specifically for pregnant women and testing recently developed MRI image acquisition techniques. The investigators aim to more reliably obtain higher quality fetal MRI images when compared to current clinical fetal MRI.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
07/24/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pregnancy
MRI Assessment of Placental Health
Recruiting
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specific correspondence between a single type of pathology and IUGR, the common result of these pathologies is placental insufficiency, which limits the maternal-fetal exchange. Oxygen and nutrition transpor... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
07/24/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Intrauterine Growth Restriction
Trial of Parkinson's And Zoledronic Acid
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
Project 1: Self-Triage by 2D Full-field Digital Mammography or Synthetic Images
Recruiting
One method of breast cancer screening involves radiologists reading digital tomosynthesis (DBT) images. DBT consists of a 3D stack of x-ray "slices" through the breast. The exam is accompanied by a 2D image like a standard mammogram, a single x-ray of the breast. In a screening setting, most cases are normal. Sometimes it is obvious that a case is normal from a quick look at the 2D image. It would speed up the process of screening if readers could dismiss a clearly normal case on the basis of th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/21/2023
Locations: Visual Attention Lab / Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Breast Cancer Screening
Inter-lobar Fissure Completion in Patients With Failed Bronchoscopic Lung Volume Reduction
Recruiting
The purpose of this protocol is to perform a pilot prospective controlled clinical trial to evaluate the potential role of lung fissure completion with pleural adhesiolysis strategy (experimental intervention) in severe emphysema/COPD patients with failed bronchoscopic lung volume reduction (BLVR) via the use of endobronchial valves (EBVs) therapy. In select patients, the lung fissure completion with adhesiolysis strategy will be performed by video-assisted thoracoscopic surgery (VATS) guided st... Read More
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
07/21/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Emphysema or COPD
Combined Zephyr Valve System With Inter-lobar Fissure Completion for Lung Volume Reduction in Emphysema
Recruiting
The purpose of this protocol is to perform a pilot prospective randomized controlled clinical trial to evaluate the potential role of lung fissure completion strategy (experimental intervention) in addition to endobronchial valve (EBV) placement (representing "standard-of-care") in select patients with severe COPD/emphysema and with evidence for <95% fissure completion between adjacent lung lobes. In select patients, lung fissure completion strategy will be performed by either video-assisted tho... Read More
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
07/21/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Emphysema or COPD
Apple Women's Health Study
Recruiting
This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research app(available on App Store), which allows a user to find, enroll, and participate in Apple-supported health-related research studies.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: Harvard T.H. Chan School of Public Health, Boston, Massachusetts
Conditions: Menstrual Cycle, Ovulation, Menstruation, Polycystic Ovary Syndrome, Infertility, Menopause, Reproduction, Reproductive Health
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism
Recruiting
The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism
Study to Assess Efficacy and Safety of Dupilumab in the Treatment of Keloids
Recruiting
The study investigates the efficacy and safety of dupilumab in the treatment of keloids
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
07/20/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Keloid
Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Recruiting
This study will assess patients who have recurrent urinary tract infections and kidney stones which are not blocking the kidney or causing other problems. Currently, we don't know if taking out these stones will improve recurrent urinary tract infections or not. Patients will make a decision with their surgeon about removing or monitoring their stone(s). Whether or not their infections continue with surgery or monitoring will be noted, and this information may help to inform future treatment dec... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Urinary Tract Infections, Kidney Stone