There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Ureteral Stent Placement After Ureteroscopy for Renal Stones: A Randomized Controlled Trial
Recruiting
The rationale for this study is to determine if there is a difference in complications among patients undergoing ureteroscopy for renal stones who receive a stent compared to not receiving a stent postoperatively.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Kidney Calculi
Apple Women's Health Study
Recruiting
This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research app(available on App Store), which allows a user to find, enroll, and participate in Apple-supported health-related research studies.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2023
Locations: Harvard T.H. Chan School of Public Health, Boston, Massachusetts
Conditions: Menstrual Cycle, Ovulation, Menstruation, Polycystic Ovary Syndrome, Infertility, Menopause, Reproduction, Reproductive Health
The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis
Recruiting
Determine the difference in the modified Rankin score at 16 weeks in participants with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis treated with "first-line" immunomodulatory therapies provided as standard-of-care, and either inebilizumab (investigational agent) or placebo.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/19/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Autoimmune Encephalitis, Encephalitis
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
Recruiting
This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.
Gender:
All
Ages:
Between 0 days and 17 years
Trial Updated:
07/19/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Drug Effect
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
All
Ages:
All
Trial Updated:
07/19/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
Muscle Catabolism and Outcomes in Children Following Cardiac Surgery
Recruiting
Background & Significance. Children with congenital heart disease (CHD) have experienced improved postoperative survival shifting the focus away from minimizing mortality to curtailing morbidities. Critical illness following cardiac surgery induces catabolism which may impact functional status. Catabolism, a state in which protein breakdown exceeds protein synthesis, can lead to lean body mass (LBM) breakdown. LBM loss has been associated with poor clinical outcomes. Muscle ultrasound (mUS) has... Read More
Gender:
All
Ages:
Between 3 months and 18 years
Trial Updated:
07/18/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, ICU Acquired Weakness, Catabolic State
BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic Syndrome
Recruiting
The goal of this research study is to find the safest and most effective dose of the study drug, BXCL701, for the treatment of Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS). The names of the study drugs involved in this study are/is: BXCL701
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders
Recruiting
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in women with hypothalamic amenorrhea (HA). The investigators are also examining whether kisspeptin can help women release eggs from their ovaries. Kisspeptin will be administered subcutaneously (SC) for two weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth and frequent blood sampling (every 10 minutes for up to two hours) wil... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
07/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism
Venetoclax Plus Inotuzumab for B-ALL
Recruiting
This research study is evaluating the safety and efficacy of administering venetoclax and inotuzumab ozogamicin in combination in patients with acute lymphoblastic leukemia (ALL) The names of the study drugs involved in this study are: Venetoclax Inotuzumab ozogamicin Dexamethasone
Gender:
All
Ages:
18 years and above
Trial Updated:
07/17/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: B-cell Acute Lymphoblastic Leukemia, B-Cell Lymphoma, ALL
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test
Recruiting
The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an oral glucose tolerance test
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
07/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Metabolic Diseases
Kisspeptin Administration in the Adult
Recruiting
The goal of this study is to learn about the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that causes the release of other hormones, including gonadotropin-releasing hormone (GnRH) in the body.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism, Kallmann Syndrome, GnRH Deficiency, PCOS, Polycystic Ovarian Syndrome, Hyperprolactinemia
Neuropeptides in Human Reproduction
Recruiting
The investigators are seeking healthy volunteers and volunteers with reproductive disorders for the study of the role of dynorphin in the reproductive system. Dynorphin is a naturally occurring opioid hormone that is blocked by naloxone. We hypothesize that naloxone, by blocking dynorphin, will stimulate production of gonadotropin-releasing hormone (GnRH) and kisspeptin, two other naturally occurring reproductive hormones.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
07/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypogonadotropic Hypogonadism