There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
Recruiting
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial. The purpose of this study is to compare glaucoma drainage device implantation in the anterior chamber (front part of the eye) and sulcus (small space between iris and front chamber of the eye) in efforts to minimize cell loss in the eye.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Glaucoma
Prospective Screening for Breast Cancer-related Lymphedema
Recruiting
The primary objectives of this study are twofold: 1) to detect and determine the level of symptoms, functional disability, and changes in quality of life that breast cancer patients experience from changes in their arms during and after treatment for breast cancer by collecting patient reported outcome measures, objective measurements, and clinical information in a prospectively maintained database and 2) to improve breast cancer-related lymphedema outcomes by early detection using objective mea... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lymphedema
Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study
Recruiting
This research is being conducted to understand if treatment can be tailored for participants with HPV-related oropharynx cancers using both clinical features (stage of the tumor, smoking status) combined with an investigational HPV blood test. The names of the test and treatments involved in this study are: NavDx® HPV ctDNA testing (HPV blood test) Radiation therapy Chemotherapy: Cisplatin, or Carboplatin and Paclitaxel (not all participants receive any or all of these agents)
Gender:
All
Ages:
22 years and above
Trial Updated:
07/10/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: HPV-Associated Oropharyngeal Squamous Cell Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma, HPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Stage, HPV-Related Squamous Cell Carcinoma, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, HPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Clinical Stage, HPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Pathologic Stage
Imaging Markers of Subclinical Cardiotoxicity in Breast Cancer
Recruiting
This research study is evaluating the use of Cardiac Magnetic Resonance Imaging (CMR) as a method of detecting early signs of damage to the heart that can be associated with anthracycline-based chemotherapy for the treatment of breast cancer.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/07/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Breast Cancer
Optimal Treatment for Recurrent Clostridium Difficile
Recruiting
The purpose of this study is to determine whether fidaxomicin and vancomycin followed by taper and pulse vancomycin treatment are superior to standard vancomycin treatment for the treatment of recurrent Clostridium difficile infection.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/07/2023
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Clostridium, Difficile, Fidaxomicin, Vancomycin
Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression
Recruiting
The goal of this research study is to determine whether hormonal therapies used early in the course of prostate cancer could increase the amount of Prostate-Specific Membrane Antigen (PSMA) as detected by PET/CT scans for participants with recurrent prostate cancer. This study will measure PSMA levels using standard PET/CT scans and participants will receive standard-of-care androgen receptor antagonist monotherapy. The names of the treatment interventions involved in this study are: Androgen... Read More
Gender:
Male
Ages:
40 years and above
Trial Updated:
07/07/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Prostate Adenocarcinoma, Prostate Cancer, Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Impact of Sunscreen Dispensers in Parks Visited by Teenagers
Recruiting
This study will evaluate the use of publicly available free sunscreen dispensers at Maine beaches and Boston parks. Aim 1: Determine the impact of DFS+ (dispensers, flyers, enhanced signage, + a social media component delivered by teen ambassadors) sun protection education on the use of free sunscreen dispensers by adolescents ages 12-18 compared with DFS (dispensers, flyers, standard signage). Aim 2: Outcomes evaluation to assess the effects of the sunscreen dispensers and the sun-safety educ... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
07/06/2023
Locations: Harvard TH Chan School of Public Health, Boston, Massachusetts
Conditions: Skin Neoplasm, Adolescent Behavior, Sunscreening Agents
An Augmented Reality Based System for Neglect Detection, Assessment, and Rehabilitation
Recruiting
The aim of this phase is to examine the feasibility and acceptability of the Augmented Reality (AR)-based and electroencephalography (EEG)-based neglect detection and rehabilitation tool.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/05/2023
Locations: Northeastern University, Boston, Massachusetts
Conditions: Stroke
Atomoxetine and DAW2022 on OSA Severity
Recruiting
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. In previous research atomoxetine and oxybutynin showed promising effect at reducing OSA severity, however they reduced arousal threshold, one of the key traits responsible for OSA. Since oxybutynin was used mainly as a hypnotic, but it is burdened by several anti-cholinergic side effects, DAW2020, a hypnotic which prolonged the total sleep time in a previous trial in OSA patients, could b... Read More
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
07/05/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
Treatment of Brain AVMs (TOBAS) Study
Recruiting
The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of uncertainty. Management may include interventional therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in combination) or conservative management. The trial has been designed to test a) whether medical management or interventional therapy will redu... Read More
Gender:
All
Ages:
5 years and above
Trial Updated:
07/04/2023
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM, BAVM
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab
Recruiting
This study will test the hypothesis that in patients with previous daratumumab exposure, combination therapy of daratumumab, pomalidomide, and dexamethasone (DPd) will yield higher complete remission (CR) rates in relapsed/refractory amyloidosis than historical pomalidomide/dexamethasone treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/02/2023
Locations: Boston University Medical Center, Boston, Massachusetts
Conditions: Amyloid, AL Amyloidosis, Refractory AL Amyloidosis
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
Recruiting
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications. After meals, a mismatch between carbohydrate absorption rate and insulin action typically leads to alternating periods of hyper- and hypoglycemia. A conceptually promising approach to control both problems is dietary carbohydrate restriction to reduce postprandial blood glucose changes and insulin needs. In a prior... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
06/29/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Type1diabetes