There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Effects of Ketosis on Brain Function in Patients With T1DM
Recruiting
The scientific goal of this study is to examine the effects of a ketogenic diet on hypoglycemia tolerance and brain function in people with type 1 diabetes mellitus (T1D) and to clarify the mechanistic role of ketones in this process. Glycemic management of T1D is typified by alternating periods of hyper- and hypo-glycemia. Because brain metabolism under usual conditions depends on glucose, acute hypoglycemia leads to immediate complications including impaired cognitive function and a counter-re... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
06/29/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Type1diabetes
Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults
Recruiting
A multicenter, randomized, parallel-group, placebo-controlled, double-blind, Phase 1/2a clinical study to investigate the safety, tolerability, immunogenicity and exploratory efficacy of a vaccine regimen consisting of an Ad26.Mos4.HIV prime and a boost with Modified Vaccinia Ankara (MVA)-BN-HIV in combination with broadly neutralizing antibodies (bNAb) PGT121, PGDM1400, and VRC07-523LS in human immunodeficiency virus type 1 (HIV-1)-infected study participants on suppressive anti-retroviral ther... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
06/29/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: HIV, Acquired Immunodeficiency Syndrome, Immunologic Deficiency Syndrome, Acquired, Sexually Transmitted Diseases, Viral, Retroviridae Infections
Very Low Carbohydrate Diets and Glucagon Response in T1DM
Recruiting
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications. After meals, a mismatch between carbohydrate absorption rate and insulin action typically leads to alternating periods of hyper- and hypoglycemia. A conceptually promising approach to control both problems is dietary carbohydrate restriction to reduce postprandial blood glucose changes and insulin needs. In a prior... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
06/29/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Type1diabetes
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT
Recruiting
This is a Phase III randomized controlled trial of a passive ROM exercise program that will be performed in infants with HLHS and other single right ventricle anomalies following the Norwood procedure at PHN and Auxiliary Centers.
Gender:
All
Ages:
29 days and below
Trial Updated:
06/28/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease
Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development
Recruiting
This study is a randomized trial comparing 2 methods of human milk fortification for preterm infants in the neonatal intensive care unit (NICU). All participating infants will receive a human milk diet comprising maternal and/or donor milk plus multi-component and modular fortifiers. In one group (control), the milk will be fortified according to routine standard of care. In the other group (intervention), the fortification will be individually targeted based on the results of point-of-care huma... Read More
Gender:
All
Ages:
Between 1 day and 21 days
Trial Updated:
06/27/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Preterm Birth, Breast Milk Expression, Nutrition Disorder, Infant, Brain Development Abnormality, Neurodevelopmental Disorders
A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment
Recruiting
The purpose of this study to find out whether codrituzumab is a safe treatment that causes few or mild side effects in children and young adults who have solid tumors that express the protein GPC3. The researchers also want to study the way codrituzumab is absorbed, distributed, and cleared from the body.
Gender:
All
Ages:
Between 1 year and 21 years
Trial Updated:
06/27/2023
Locations: Dana Farber Cancer Institute (Data Collection Only), Boston, Massachusetts
Conditions: Primary Extra-cranial Solid Tumor, Recurrent or Refractory Glypican 3 (GPC3)
Proactive Therapeutic Drug Monitoring Based Adalimumab Therapy Optimization in Patients With Rheumatoid Arthritis
Recruiting
Current standard of care of rheumatoid arthritis (RA) management includes a routine clinical assessment of disease activity to adjust therapy. For the most part, therapy adjustment for therapy non-response and/or suboptimal therapy response leads to therapy switch within the same class of therapy or to a different class of therapy. The lack of objective data to titrate dose of a given therapeutic agent for maximal possible efficacy makes it difficult for providers and payors to titrate dose as n... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/26/2023
Locations: Boston Medical Center, Rheumatology Clinic, Boston, Massachusetts
Conditions: Rheumatoid Arthritis
Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts
Recruiting
This research study is testing if Talazoparib is an effective treatment for patients with AML and MDS that have a mutation in the cohesin complex.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/26/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Leukemia
Individualized Vocational and Educational Support and Training for Clinical High Risk for Psychosis (InVEST)
Recruiting
The purpose of this study is to test the efficacy of InVEST (Individualized Vocational and Educational Support and Training) for CHR-P (clinical high risk for psychosis) to address specific role functioning difficulties associated with the CHR-P phase. Our specific goals are: Part 1: Preliminary open trial of InVEST (n = 8) to collect preliminary feasibility and acceptability data by providing the intervention, administering assessments, and collecting focus group and self-report feedback from... Read More
Gender:
All
Ages:
Between 12 years and 22 years
Trial Updated:
06/23/2023
Locations: Beth Israel Deaconess Medical Center/ Massachusetts Mental Health Center, Boston, Massachusetts
Conditions: Clinical High Risk for Psychosis
Vaginal Microbiota Transplant
Recruiting
This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
06/23/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Recurrent Bacterial Vaginosis
Mind-body Approach and Gut Microbiota in Osteoarthritis
Recruiting
This exploratory study is to compares mechanisms of mind-body exercise with wellness education program on gut microbiota for osteoarthritis as a basis for a future large-scale trial.
Gender:
All
Ages:
55 years and above
Trial Updated:
06/22/2023
Locations: Tufts Medical Center, Rheumatology, Boston, Massachusetts
Conditions: Osteoarthritis
Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial
Recruiting
This phase II trial investigates how well biomarkers on PET/CT imaging drive early discontinuation of anti-PD-1 therapy in patients with stage IIIB-IV melanoma that cannot be removed by surgery (unresectable). Anti-PD-1 therapy has become a standard therapy option for patients with unresectable melanoma. This trial is being done to determine if doctors can safely shorten the use of standard of care anti-PD1 therapy for melanoma by using biomarkers seen on PET/CT imaging and tumor biopsy.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Advanced Melanoma, Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IIID Cutaneous Melanoma AJCC v8, Pathologic Stage IV Cutaneous Melanoma AJCC v8, Unresectable Acral Lentiginous Melanoma, Unresectable Melanoma, Unresectable Mucosal Melanoma