There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors
Recruiting
First-in-human, Phase I/II, Multicenter, Open-Label Study of EMB-01 in Patients with Advanced/Metastatic Solid Tumors
Gender:
All
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
All
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: Harvard University, Boston, Massachusetts
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Recruiting
Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benzodiazepines, which can have severe side effects and can be ineffective. Interventions combining virtual reality with olfactory stimuli are a promising alternative to opioids and benzodiazepines in the treatment of pain and anxiety around the time of surgery. The aim of this study is to evaluate the... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Postoperative Pain, Anxiety Postoperative, Opioid Use
Perception in Parkinson's Disease
Recruiting
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to pa... Read More
Gender:
All
Ages:
Between 40 years and 110 years
Trial Updated:
05/24/2023
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson's Disease, Visual Hallucination, Perception
Bovine Colostrum to Prevent Absorption of Gluten
Recruiting
To investigate the use of hyperimmune bovine colostrum to reduce gluten absorption. A double-blind, cross-over study will be performed in which persons who are following a strict gluten-free diet will be challenged with oral gluten with or without the bovine colostrum.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Celiac Disease, Gluten Sensitivity, Non-celiac Gluten Sensitivity
Role of Dietary Habits in Efficacy of Bariatric Surgery - Study B
Recruiting
The purpose of the study is to compare dietary habits after bariatric surgery in patients with poor weight loss versus good weight loss outcomes.
Gender:
All
Ages:
Between 22 years and 62 years
Trial Updated:
05/21/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Bariatric Surgery, Sleeve Gastrectomy, Obesity
Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders
Recruiting
The purpose of this protocol is to create an active natural history cohort of patients with degenerative movement disorders, tracked in a clinical setting with clinical rating scales and neuroimaging. The overarching rationale is that neurodegenerative diseases may be heterogeneous, complex disorders. A new way of performing clinical trials in these patients may be in order and this protocol aims to build a longitudinally tracked clinical trial-ready cohort of patients. The purpose of this proto... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Neurodegenerative Diseases, sca3, MSA - Multiple System Atrophy, Ataxia, Synucleinopathies
COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure
Recruiting
This is a randomized, open-label, initiative within the Mass General Brigham healthcare system testing two remote care strategies for optimizing the prescription of guideline-directed medical therapies in patients with heart failure, regardless of left ventricular ejection fraction (LVEF).
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/19/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Heart Failure
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Recruiting
RGX-314 is being developed as a potential novel one-time gene therapy treatment for the treatment of neovascular (wet) age related macular degeneration (wet AMD). Wet AMD is characterized by loss of vision due to new, leaky blood vessel formation in the retina. Wet AMD is a significant cause of vision loss in the United States, Europe and Japan, with up to 2 million people living with wet AMD in these geographies alone. Current anti-VEGF therapies have significantly changed the landscape for tre... Read More
Gender:
All
Ages:
Between 50 years and 89 years
Trial Updated:
05/18/2023
Locations: Boston Location, Boston, Massachusetts
Conditions: Neovascular Age-Related Macular Degeneration (nAMD)
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) Without Center Involved-Diabetic Macular Edema (CI-DME)
Recruiting
RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of diabetic retinopathy, a chronic and progressive complication of diabetes mellitus. Diabetic retinopathy (DR) is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that leads to further deterioration of functional vision. Despite the availability of current treatments, diabetic retinopathy remains the l... Read More
Gender:
All
Ages:
Between 25 years and 89 years
Trial Updated:
05/18/2023
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Diabetic Retinopathy (DR)
Home OCT Guided Management Study of Subjects Diagnosed With Neovascular-AMD
Recruiting
During the last 25 years, OCT has become one of the most common imaging technologies used to diagnose and monitor retinal diseases, including AMD. The OCT self-imaging capabilities of the Notal Vision Home OCT (NVHO) system for retinal fluid visualization in the central 10 degrees were validated during several prospective clinical studies1,2,3,4,5. This study is designed to evaluate the retinal fluid exposure of eyes with NV-AMD, using the NVHO system to guide therapy.
Gender:
All
Ages:
55 years and above
Trial Updated:
05/18/2023
Locations: Ophthalmic Cons. of Boston, Boston, Massachusetts
Conditions: Retinal Neovascularization
Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes
Recruiting
Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm. To address this problem, the investigators will use key stakeholder input to refine and implement an interoperable health information exchange platform that integrates with the electronic health record and improves the reliability of and access to necessary clinical information in three use cases involving transfer of pat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2023
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Infections, Heart Failure, COPD Exacerbation, Asthma, Gastrointestinal Diseases, Cardiac Event, Arrythmia, Renal Failure, Renal Disease, Rheumatic Diseases, Urologic Diseases, Neurologic Disorder, Hematologic Diseases, Oncology Problem, Shock, Critical Illness