There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Beacon Sensors and Telerehabilitation for Low Vision
Recruiting
The successful application of magnification devices for reading and daily tasks is predicated on their correct use by individuals with low vision (LV). Barriers related to transportation, geography, and/or co-morbidities often limit LV patients' ability to attend several in-office training sessions as part of low vision rehabilitation (LVR) to optimize visual function with magnification devices. A promising solution is real-time videoconferencing to provide telerehabilitation, involving remotely... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2023
Locations: New England College of Optometry, Boston, Massachusetts
Conditions: Low Vision
The Boston Pace Study
Recruiting
Right ventricular (RV) pacing can cause left ventricular systolic dysfunction in 10- 20% of patients. Biventricular pacing had previously been shown to prevent left ventricular systolic dysfunction. However, implantation of coronary sinus lead increases procedural risk and can be limited by higher threshold and phrenic nerve capture. HIS pacing has been evaluated as an alternative pacing strategy, but its routine use was limited by difficulty of the procedure, success rate and high pacing thresh... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Left Bundle Branch Area Pacing
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Asthma
Intermuscular Coherence as a Biomarker for ALS
Recruiting
The specific aims of this study are to: Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a measure of intermuscular coherence (IMC-βγ), when added to current diagnostic criteria (Awaji criteria), can differentiate ALS from mimic diseases more accurately and earlier than currently possible. Characterize IMC-βγ in neurotypical subjects by age, sex, race, and ethnicity. Follow a cohort of ALS patie... Read More
Gender:
All
Ages:
Between 20 years and 80 years
Trial Updated:
05/16/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis
Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases
Recruiting
This study seeks to learn more about the vitamin D receptor and its relationship to colon cancer. The Vitamin D receptor is found in colon cancer cells. When Vitamin D binds to the receptor in the cancer cells, it may stop cancer cells from growing abnormally and may cause cancer cell death. Vitamin D has been used in other research studies and information from those other research studies suggests that Vitamin D may help in the treatment of colon cancer. Participants will receive either high-d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Stage, Colon Cancer, Stage I-III Colon Cancer, Stage IV Colon Cancer With Resectable Liver Metastases
Sodium Nitroprusside in Early Course Schizophrenia
Recruiting
Peripheral inflammation and microvascular dysfunction are central to the pathophysiology of schizophrenia (SZ). Retinal imaging allows for the accurate quantitative assessment of the condition of retinal microvessels, and early studies implicate microvascular dysfunction in SZ, but the specific pathophysiological mechanisms underlying greater length, density, capillary network and diameter are not yet entirely understood. Anti-inflammatory drug trials in SZ suggest that Early Course Schizophreni... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
05/12/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Schizophrenia, Schizoaffective Disorder
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis (AD)
Recruiting
The objective of this study is to describe and compare the incidence of adverse pregnancy outcomes (spontaneous abortion/miscarriage, stillbirth) and prevalence of infant outcomes (major congenital malformations [MCMs], small for gestational age [SGA]) in women with AD who are treated with dupilumab during pregnancy relative to women with AD who are not treated with dupilumab during pregnancy.
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
05/11/2023
Locations: Regeneron Research Site, Boston, Massachusetts
Conditions: Adverse Pregnancy Outcomes, Atopic Dermatitis
EndoBarrier System Pivotal Trial(Rev E v2)
Recruiting
A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the EndoBarrier System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study. A multi-center, double-blinded, randomized, sham-controlled trial to evaluate the safety and effectiveness of the EndoBarrier System plus moderate intensity lifestyle and dietary counseling compliant with 2019 ADA Standard of Care as compared to a sham control receiving moderate intensity... Read More
Gender:
All
Ages:
Between 30 years and 65 years
Trial Updated:
05/09/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Diabetes type2, Obesity
Sirtuin-NAD Activator in Alzheimer's Disease
Recruiting
The primary objectives are to: To determine whether MIB-626, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrations of MIB-626 and its key metabolites, nicotinamide (NAM), NR, 2-PY, and MeNAM at baseline and on day 90 at steady state. To evaluate whether oral MIB-626 administration engages the sirtuin-NAD pathway by determining the abundance of NAD (a SIRT1 substrate) in the brain using ultra-high field 7T magn... Read More
Gender:
All
Ages:
Between 55 years and 85 years
Trial Updated:
05/09/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Alzheimer's Disease (Incl Subtypes), Dementia
The T1D Exchange Registry
Recruiting
The T1D Exchange Registry is a research study, conducted over time, for individuals with type 1 diabetes and their supporters. Participants volunteer to provide their data for research (for example, by answering questions in annual surveys). Once enrolled, Registry participants have the opportunity to sign up for other studies on various topics related to type 1 diabetes. To participate, you will be asked to: Read and sign an online informed consent form Take a survey describing specific demog... Read More
Gender:
All
Ages:
All
Trial Updated:
05/04/2023
Locations: T1D Exchange, Boston, Massachusetts
Conditions: Diabetes Mellitus, Type 1, Diabetes, Type 1 Diabetes, Diabetes Mellitus
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
Recruiting
Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingd... Read More
Gender:
Male
Ages:
21 years and above
Trial Updated:
05/04/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Prostate Cancer
Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children
Recruiting
This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).
Gender:
All
Ages:
5 years and below
Trial Updated:
05/04/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Cystic Fibrosis