There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser
Recruiting
Hypertrophic Burn Scars (HTBS) are often treated with Fractional CO2 laser therapy to improve cosmetic appearance. It has been noted that this leads to a reduction in the pain and itch associated with this type of scars. While this phenomenon is commonly described in the literature, the mechanism of pain and itch reduction in unclear. The investigators aim to better understand this process by histological evaluation of HTBS at different stages of laser treatment.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hypertrophic Scar, Burn Scar
Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Merkel Cell Carcinoma (MCC) who have failed treatment with at least one anti-PD-1 or anti-PD-L1 immunotherapy or in combination with avelumab in MCC patients who are anti-PD-1 or anti-PD-L1 treatment naïve. Inhibition of MDM2 is a novel mechanism of action in MCC.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Merkel Cell Carcinoma
Implantable Microdevice In Primary Brain Tumors
Recruiting
This pilot study will assess the safety and feasibility of using an implantable microdevice to measure local intratumor response to chemotherapy and other clinically relevant drugs in malignant brain tumors. The device involved in this study is called a microdevice. The drugs used in this study will only include drugs already used systemically for the treatment of gliomas.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Grade II Glioma, Grade III Glioma, Grade IV Glioma, Astrocytoma, Oligodendroglioma of Brain, Anaplastic Astrocytoma of Brain, Anaplastic Oligodendroglioma, Glioblastoma
Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide
Recruiting
The overarching goal of this study is to examine the acute vasoreactive response to both inhaled nitric oxide and inhaled epoprostenol across both traditionally and non-traditionally interrogated phenotypes in PH, and to further characterize the relationship of vasoreactivity to disease severity and PH phenotype.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/25/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pulmonary Hypertension
Circadian Influence on Prolonged Exposure Therapy for PTSD
Recruiting
Proposed research will examine time-of-day effects on trauma-related fear extinction using Prolonged Exposure Therapy (PE) telemedicine for Posttraumatic Stress Disorder (PTSD) in the National Center for PTSD (NCPTSD). The primary mechanistic outcome measure will be change in psychophysiological reactivity to script-driven imagery (SDI-PR) measured, in person, at pre-treatment, after 5 PE sessions (mid-treatment), and after all 10 PE sessions (post-treatment). A secondary mechanistic outcome wil... Read More
Gender:
All
Ages:
Between 25 years and 45 years
Trial Updated:
02/25/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: PTSD
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
Recruiting
This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatment with medications that block aldosterone can reduce that risk. This study is trying to learn whether treatment with a medication that blocks aldosterone can improve heart function in people who make... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
02/24/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Primary Aldosteronism, Hypertension
The Safety and Pharmacokinetics Preliminary Efficacy of IMP7068 in Patients With Advanced Solid Tumors
Recruiting
A Phase 1 Dose Escalation and Expansion Study of IMP7068 Monotherapy in Advanced Solid Tumors
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Advanced Solid Tumors
SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression
Recruiting
The objectives of this study are to determine the safety and effectiveness of the SFM Anastomosis Device when used to create a small bowel anastomosis for patients undergoing ileostomy reversal as compared with a propensity-matched historic control group of patients who underwent ileostomy reversal using a conventional closure technique (sutures or stapler).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/19/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Retraction of Ileostomy
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
Recruiting
The aim of this study is to determine if suvorexant can help treat the severity of insomnia in midlife women who are pre-diabetic.
Gender:
Female
Ages:
Between 40 years and 65 years
Trial Updated:
02/16/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia, Diabetes, Menopause
Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury
Recruiting
Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivi... Read More
Gender:
All
Ages:
8 years and below
Trial Updated:
02/16/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Acute Kidney Injury
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects
Recruiting
The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma
Gender:
All
Ages:
1 year and above
Trial Updated:
02/15/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Neuroblastoma, Neuroectodermal Tumors, Neoplasms
Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors
Recruiting
A Phase 1, first-in-human study of EP31670, a dual BET and CBP/p300 inhibitor in patients with targeted advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/15/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Castrate Resistant Prostate Cancer, NUT Carcinoma