There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
NCT05728697
Recruiting
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, which have traditionally had less accurate results in this population. The main questions it aims to answer are: Determine accuracy of EUS-SWE for liver fibrosis screening compared to other non-invasi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity
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A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (AMD) or Subjects With Diabetic Macular Edema (DME)
NCT05387837
Recruiting
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in subjects with Neovascular (wet) Age-Related Macular Degeneration (AMD) or subjects with Diabetic Macular Edema (DME)
Gender:
All
Ages:
18 years and above
Trial Updated:
02/09/2023
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
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A Study to Evaluate the Efficacy and Safety of Novel Treatment Combinations in Participants With Ovarian Cancer
NCT03574779
Recruiting
This study will evaluate the efficacy and safety of niraparib and novel treatment combinations of niraparib as described within each cohort-specific supplement in participants with ovarian, fallopian tube, or primary peritoneal cancer. Cohort A (single arm) includes participants with recurrent ovarian cancer. Cohort B will not be initiated. Cohort C (randomized-2 arms) includes participants with newly diagnosed ovarian cancer.
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/09/2023
Locations: GSK Investigational Site, Boston, Massachusetts +1 locations
Conditions: Ovarian Neoplasms
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Assess Fibrin in Brains With AD/ADRD
NCT05336695
Recruiting
The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
02/07/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Dementia of Alzheimer Type
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The PROMISE Study: Duavee in Women With DCIS
NCT02694809
Recruiting
The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee®) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat certain symptoms of menopause such as hot flashes. Since it is not approved in women with DCIS, its use in this study is experimental. This study will also look at whether taking t... Read More
Gender:
Female
Ages:
Between 18 years and 79 years
Trial Updated:
02/06/2023
Locations: Dana Farber/Partners Cancer Care Inc, Boston, Massachusetts
Conditions: Ductal Breast Carcinoma In Situ, Postmenopausal
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Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
NCT05236153
Recruiting
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velo... Read More
Gender:
All
Ages:
All
Trial Updated:
02/06/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
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Testing Effects of Melatonin on Uterine Contractions in Women
NCT05358834
Recruiting
The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women. The basic physiology work has been conducted in in vitro models of the human myometrium characterizing its responses to melatonin, and in pilot in vivo studies correlating the number of uterine contractions with melatonin concentrations that were manipulated by different types of light exposure. The planned experiment... Read More
Gender:
Female
Ages:
Between 18 years and 35 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pregnant Women
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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
NCT00985049
Recruiting
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Cardiovascular Diseases
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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
NCT00833313
Recruiting
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your... Read More
Gender:
All
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation
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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
NCT01177618
Recruiting
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.
Gender:
All
Ages:
All
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Chronic Obstructive Pulmonary Disease
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ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia
NCT05543694
Recruiting
To estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor after receiving a lidocaine "test dose"
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Labor Pain, Analgesia
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Multimodality Intervention for Function and Metabolism in SCI
NCT03576001
Recruiting
The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury. The trial will test the hypothesis that a Home-Based Multimodality Functional Recovery and Metabolic Health Enhancement Program that addresses multiple pathophysiologic factors in SCI and includes functional electrical stimulation during leg cycling (FES-LC) plus arm ergometry and an androgen will be more efficacious... Read More
Gender:
All
Ages:
Between 19 years and 70 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Spinal Cord Injuries
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