There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
NCT05728697
Recruiting
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, which have traditionally had less accurate results in this population. The main questions it aims to answer are: Determine accuracy of EUS-SWE for liver fibrosis screening compared to other non-invasi... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity
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A Study to Evaluate the Efficacy and Safety of Novel Treatment Combinations in Participants With Ovarian Cancer
NCT03574779
Recruiting
This study will evaluate the efficacy and safety of niraparib and novel treatment combinations of niraparib as described within each cohort-specific supplement in participants with ovarian, fallopian tube, or primary peritoneal cancer. Cohort A (single arm) includes participants with recurrent ovarian cancer. Cohort B will not be initiated. Cohort C (randomized-2 arms) includes participants with newly diagnosed ovarian cancer.
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/09/2023
Locations: GSK Investigational Site, Boston, Massachusetts +1 locations
Conditions: Ovarian Neoplasms
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A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Subjects With Neovascular (Wet) Age-Related Macular Degeneration (AMD) or Subjects With Diabetic Macular Edema (DME)
NCT05387837
Recruiting
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in subjects with Neovascular (wet) Age-Related Macular Degeneration (AMD) or subjects with Diabetic Macular Edema (DME)
Gender:
All
Ages:
18 years and above
Trial Updated:
02/09/2023
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
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Assess Fibrin in Brains With AD/ADRD
NCT05336695
Recruiting
The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
02/07/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Dementia of Alzheimer Type
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ED90 of Epidural Bupivacaine With Lidocaine for the Initiation of Labor Analgesia
NCT05543694
Recruiting
To estimate the dose of bupivacaine required to achieve initial effective comfort in 90% of patients (ED90) via the epidural (DPE or EPL) technique in women undergoing labor after receiving a lidocaine "test dose"
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Labor Pain, Analgesia
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Multimodality Intervention for Function and Metabolism in SCI
NCT03576001
Recruiting
The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury. The trial will test the hypothesis that a Home-Based Multimodality Functional Recovery and Metabolic Health Enhancement Program that addresses multiple pathophysiologic factors in SCI and includes functional electrical stimulation during leg cycling (FES-LC) plus arm ergometry and an androgen will be more efficacious... Read More
Gender:
All
Ages:
Between 19 years and 70 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Spinal Cord Injuries
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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
NCT01258231
Recruiting
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction, Heart Failure
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Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery
NCT03466125
Recruiting
The purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery. The Specific Aims of the proposed study are to: Identify the predictors of postoperative atrial fibrillation after discharge from hospital. Identify the frequency of readmission to hospital, or other resource use such as Emergency Department or outpatient visit, for the treatment or prophylax... Read More
Gender:
All
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Stroke, Acute, Death
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Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
NCT04880265
Recruiting
Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development... Read More
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Cardiac Surgery
Register for Updates
Image Guided VATS vs. VATS Resection
NCT03623958
Recruiting
To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Lung Cancer
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Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
NCT05236153
Recruiting
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velo... Read More
Gender:
All
Ages:
All
Trial Updated:
02/06/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
Register for Updates