There are currently 2702 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Gamma Induction for Alzheimer's Disease
Recruiting
Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) plaque buildup and phosphorylated tau (p-tau) in the brain, as well as widespread neurodegeneration. Amyloid-β and tau are proteins that build up in the brain that may contribute to memory problems. The evidence suggests that both amyloid and tau play a critical role in AD and interventions that reliably and safely decrease the intracerebral burden of amyloid or tau could potentially be of marked clinical importance. Currently, therapeu... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
12/05/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Alzheimer Disease, Mild Cognitive Impairment
PET Fibrin Imaging of DVT and PE
Recruiting
This study aims to investigate a novel positron emission tomography(PET)-probe for imaging of fresh intravascular blood clots in pulmonary embolism (PE) and deep venous thrombosis (DVT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pulmonary Embolism, Deep Vein Thrombosis, Venous Thromboembolism
International CDKL5 Clinical Research Network
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
ALL
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: Harvard Medical School/Boston Children's Hospital, Boston, Massachusetts
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)
Recruiting
The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: CHF, ADHF, Control
Molecular Imaging of Primary Amyloid Cardiomyopathy
Recruiting
Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will develop a novel approach to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac dysfunction, in order to guide the development of novel life-saving treatments.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/01/2023
Locations: Brigham and Womens' Hospital, Boston, Massachusetts
Conditions: Amyloidosis, Primary, Cardiomyopathy
Positron Emission Tomography (PET) Imaging of Thrombosis
Recruiting
The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invasive alternative to the current standard-of-care methods.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, COVID-19, Cancer, Thrombosis
Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions
Recruiting
This study aims to predict and minimize post-discharge adverse events (AEs) during care transitions through early identification and escalation of patient-reported symptoms to inpatient and ambulatory clinicians by way of predictive algorithms and clinically integrated digital health apps. We will (1) develop and prospectively validate a predictive model of post-discharge AEs for patients with multiple chronic conditions (MCC); (2) combine, adapt, extend, and iteratively refine our EHR-integrate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/01/2023
Locations: Brigham and Women's Faulkner Hospital, Boston, Massachusetts +1 locations
Conditions: Multiple Chronic Conditions, Adverse Event
Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
Recruiting
The primary aim of our pilot study is to determine whether fibrosis in the heart can be measured with \[68Ga\]CBP8, a positron emission tomography (PET) probe, using PET/magnetic resonance imaging (MRI) imaging, in 30 individuals with documented cardiac amyloidosis. The investigators will also enroll 15 individuals with recent myocardial infarction and 15 individuals with hypertrophic cardiomyopathy as positive controls for fibrosis, and the investigators will enroll 5 individuals without cardio... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/01/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Cardiac Amyloidosis
Effects of an Algorithmically Enhanced Personalized Music-based Intervention in Patients With Dementia
Recruiting
This 6 - 12 week longitudinal study will include patients with Dementia. Participants will be randomized into one of two groups: a) an intervention group, in which patients will listen to music using Rubato Life app, and b) a control group, in which patients will receive standard of care. Patients in intervention group will be asked to listen to at least 30 minutes per day, (or a total of 3.5 hours per week) for a period of 6 -12 weeks, coming up to their scheduled follow up appointment. Patie... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Saint Elizabeth's Medical Center, Boston, Massachusetts
Conditions: Music
Deucravacitinib for the Treatment of Palmoplantar Pustulosis
Recruiting
A prospective, single-arm, open-label trial of deucravacitinib 6 mg daily in patients with PPP. All participants will receive deucravacitinib 6 mg daily for 24 weeks, with study visits every 4 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Palmoplantar Pustulosis
Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
Recruiting
The overall goal of this pilot randomized trial is to obtain necessary prerequisite data to conduct a randomized controlled intervention to test the effect of vitamin K supplementation on knee osteoarthritis progression and related functional decline. To address critical parameters required to design this larger RCT, we will conduct a double-blind, 2-armed, parallel-group intervention study, with a placebo run-in, in which 50 adults with mild to moderate knee OA and low baseline vitamin K status... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
11/27/2023
Locations: Tufts University, Boston, Massachusetts
Conditions: Osteo Arthritis Knee
Left Bundle Branch Area Mapping for Conduction System Pacing
Recruiting
This study will utilize 3D mapping as a tool to explore electro-anatomical and electrocardiographic characteristics of the Left Bundle Branch Area. We plan on prospectively reviewing the data found from 3D mapping the left bundle branch implantation cases and using the data to improve understanding of electro-anatomical characteristics of this area for a better definition of the implantation target and depth.
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
11/22/2023
Locations: St. Elizabeth's Medical Center, Boston, Massachusetts
Conditions: Left Bundle-Branch Block, Pacemaker DDD