There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
NCT05236153
Recruiting
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velo... Read More
Gender:
All
Ages:
All
Trial Updated:
02/06/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
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Testing Effects of Melatonin on Uterine Contractions in Women
NCT05358834
Recruiting
The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women. The basic physiology work has been conducted in in vitro models of the human myometrium characterizing its responses to melatonin, and in pilot in vivo studies correlating the number of uterine contractions with melatonin concentrations that were manipulated by different types of light exposure. The planned experiment... Read More
Gender:
Female
Ages:
Between 18 years and 35 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pregnant Women
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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
NCT00985049
Recruiting
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Cardiovascular Diseases
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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
NCT00833313
Recruiting
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your... Read More
Gender:
All
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation
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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
NCT01177618
Recruiting
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.
Gender:
All
Ages:
All
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Chronic Obstructive Pulmonary Disease
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The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
NCT03767426
Recruiting
To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation.... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
02/04/2023
Locations: Tony Cunningham, Boston, Massachusetts
Conditions: Sleep Deprivation, Sleep
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An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
NCT04108130
Recruiting
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of hospitalization. The objective of the study is to develop and implement perioperative strategies to eliminate PPCs in abdominal surgery, the field with the largest absolute number of PPCs. We will conduct a randomized controlled pragmatic trial in 750 studied participants. The eff... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Postoperative Pulmonary Complications
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Sotagliflozin Safety and Tolerability Among Renal Transplant Recipients
NCT05405556
Recruiting
This is an investigator-initiated, randomized controlled trial in adult KTRs (N=50) with stable allograft function to assess: 1) the reversibility of the expected acute changes in eGFR with sotagliflozin (donated by Lexicon); 2) proportion of patients completing the protocol according to different eGFR reporting strategies (using a predefined algorithm to manage the expected pharmacological effect of sotagliflozin on eGFR); 3) safety and tolerability of sotagliflozin.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Kidney Transplant
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Improving the Part C Early Intervention Service Delivery System for Children With ASD
NCT05114538
Recruiting
Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system's capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research project is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early... Read More
Gender:
All
Ages:
Between 16 months and 30 months
Trial Updated:
01/27/2023
Locations: University of Massachusetts Boston, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
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Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History.
NCT05284305
Recruiting
Desmoid tumors (DT) are rare disease of intermediate malignancy with variable and often unpredictable clinical course. There is a growing interest in defining potential risk of recurrence or progression during or after pregnancy and in identifying potential obstetrical risks and infertility rate of desmoid patients. Aim of the study: to define the impact of pregnancy on diagnosis, progression and recurrence of DT; to define the risks related to DT of obstetrical risks and decisions to interrup... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/26/2023
Locations: Brigham and Women Hospital / Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Desmoid, Desmoid; Abdominal, Pregnancy Loss, Pregnancy Complications
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Gut Recovery In Patients Following Surgery
NCT05712525
Recruiting
The purpose of the study is to determine if the myoelectrical measurements made by the G-Tech Wireless Patch System correlate with clinical markers of postoperative recovery such as passage of flatus/bowel movement, oral tolerance of diet and discharge readiness. Subsequently the data will be studied to establish which information in the signals is important in determining when to feed patients and possibly discharge them..
Gender:
All
Ages:
18 years and above
Trial Updated:
01/25/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Gastrointestinal Diseases, Ileus
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Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Boston, Massachusetts
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
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