There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
NCT01258231
Recruiting
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction, Heart Failure
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Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery
NCT03466125
Recruiting
The purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery. The Specific Aims of the proposed study are to: Identify the predictors of postoperative atrial fibrillation after discharge from hospital. Identify the frequency of readmission to hospital, or other resource use such as Emergency Department or outpatient visit, for the treatment or prophylax... Read More
Gender:
All
Ages:
Between 20 years and 99 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Stroke, Acute, Death
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Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
NCT04880265
Recruiting
Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development... Read More
Gender:
All
Ages:
Between 20 years and 90 years
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Cardiac Surgery
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Image Guided VATS vs. VATS Resection
NCT03623958
Recruiting
To evaluate workflow and outcomes of iVATS and standard VATS for small pulmonary nodules. The outcomes of the patients will be evaluated separately as there will be no direct comparison of the two arms.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Lung Cancer
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The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
NCT03767426
Recruiting
To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation.... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
02/04/2023
Locations: Tony Cunningham, Boston, Massachusetts
Conditions: Sleep Deprivation, Sleep
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An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
NCT04108130
Recruiting
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of hospitalization. The objective of the study is to develop and implement perioperative strategies to eliminate PPCs in abdominal surgery, the field with the largest absolute number of PPCs. We will conduct a randomized controlled pragmatic trial in 750 studied participants. The eff... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Postoperative Pulmonary Complications
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Sotagliflozin Safety and Tolerability Among Renal Transplant Recipients
NCT05405556
Recruiting
This is an investigator-initiated, randomized controlled trial in adult KTRs (N=50) with stable allograft function to assess: 1) the reversibility of the expected acute changes in eGFR with sotagliflozin (donated by Lexicon); 2) proportion of patients completing the protocol according to different eGFR reporting strategies (using a predefined algorithm to manage the expected pharmacological effect of sotagliflozin on eGFR); 3) safety and tolerability of sotagliflozin.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Kidney Transplant
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Improving the Part C Early Intervention Service Delivery System for Children With ASD
NCT05114538
Recruiting
Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system's capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research project is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early... Read More
Gender:
All
Ages:
Between 16 months and 30 months
Trial Updated:
01/27/2023
Locations: University of Massachusetts Boston, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
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Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History.
NCT05284305
Recruiting
Desmoid tumors (DT) are rare disease of intermediate malignancy with variable and often unpredictable clinical course. There is a growing interest in defining potential risk of recurrence or progression during or after pregnancy and in identifying potential obstetrical risks and infertility rate of desmoid patients. Aim of the study: to define the impact of pregnancy on diagnosis, progression and recurrence of DT; to define the risks related to DT of obstetrical risks and decisions to interrup... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/26/2023
Locations: Brigham and Women Hospital / Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Desmoid, Desmoid; Abdominal, Pregnancy Loss, Pregnancy Complications
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Gut Recovery In Patients Following Surgery
NCT05712525
Recruiting
The purpose of the study is to determine if the myoelectrical measurements made by the G-Tech Wireless Patch System correlate with clinical markers of postoperative recovery such as passage of flatus/bowel movement, oral tolerance of diet and discharge readiness. Subsequently the data will be studied to establish which information in the signals is important in determining when to feed patients and possibly discharge them..
Gender:
All
Ages:
18 years and above
Trial Updated:
01/25/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Gastrointestinal Diseases, Ileus
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Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
NCT03683680
Recruiting
This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mesothelioma
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