There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Menstrual-phase-dependent Differences in Response to Sleep Loss
NCT05381532
Recruiting
This study is designed to assess how healthy premenopausal women respond to different patterns of sleep loss at different times in the menstrual cycle.
Gender:
Female
Ages:
Between 18 years and 35 years
Trial Updated:
11/21/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Sleep Deprivation
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STAMP+CBT mHealth for Cancer Pain
NCT05403801
Recruiting
The purpose of this study is to test whether a mobile application developed to help people with cancer pain is useful and helpful to patients with cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2022
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Active Cancer, Active Cancer Treatment, Advanced Cancer, Palliative Care, Chronic Pain Due to Cancer
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Improving Spatial Perception and Speech Understanding in Multitalker Mixtures
NCT05260307
Recruiting
The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/16/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Hearing Loss
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TruGraf® Long-term Clinical Outcomes Study
NCT04491552
Recruiting
This is a prospective, multi-center, observational study. Subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at study enrollment and thereafter every 3 months. In addition subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at any time there is a clinical suspicion of acute rejection. Data collection for the primary objective extends over a 2-year period.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Kidney Transplant Rejection
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Let's Know!2: Language-focused Intervention for Children at Risk of Comprehension Difficulties
NCT05133479
Recruiting
In the proposed project, the investigators will conduct a multisite randomized controlled trial (RCT) to determine the efficacy of Let's Know!2, a small-group, language focused comprehension intervention, on children's lower- and higher-level language skills and comprehension skills in the short- and long-term (Specific Aims 1 and 2). The investigators will also explore whether intervention effects are moderated by dosage, initial language skill, developmental language disorder (DLD) status, wor... Read More
Gender:
All
Ages:
Between 5 years and 12 years
Trial Updated:
11/09/2022
Locations: MGH Institute of Health Professions, Boston, Massachusetts
Conditions: Language Disorders in Children
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The Transitions Project: Efficacy Trial
NCT05087251
Recruiting
The aim of this study is to evaluate the efficacy of a brief psychoeducational intervention to improve quality of life in patients with lung cancer who are transitioning from active treatment to surveillance.
Gender:
All
Ages:
21 years and above
Trial Updated:
11/09/2022
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts +1 locations
Conditions: Lung Cancer
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Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients
NCT04022161
Recruiting
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This ancillary study aims to assess the effects of Nitric Oxide on plasma reduction-oxidation reactions of patients undergoing cardiac surgery requirin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/09/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cardiovascular Diseases, Oxidative Stress, Endothelial Dysfunction
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Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies
NCT04649112
Recruiting
This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: CD19 Expressing Malignancies, Hematologic Malignancy
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Effects of Nitric Oxide on the Endothelium During Hemolysis.
NCT03748082
Recruiting
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This ancillary study aims to assess the effects of Nitric Oxide on vascular responsiveness and on endothelial function during hemolysis in patients wit... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases, Cardiovascular Risk Factor
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Validation of Aspiration Markers in Intubated Patients
NCT02598713
Recruiting
The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube [ETT] cuff leakage) in mechanically ventilated, critically ill patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: Massachussets General Hospital, Boston, Massachusetts
Conditions: Pneumonia, Aspiration
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Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients
NCT03202641
Recruiting
The goal of this interventional crossover study, in intubated and mechanically ventilated Acute Respiratory Distress Syndrome (ARDS) patients, is to compare two positive end-expiratory pressure (PEEP) titration techniques regarding: respiratory mechanics, gas exchange, changes in aeration, ventilation/perfusion matching its impact on cardiac function, especially the right heart (RH). The PEEP titration techniques are: PEEP selection based on low PEEP/high FiO2 table ("PEEPARDSnet") and lung recr... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/08/2022
Locations: Massachussets General Hospital, Boston, Massachusetts
Conditions: ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication, Alveolar Edema, Right Heart Failure, Right Ventricular Dysfunction
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Study on Allopregnanolone and Depression in Perimenopausal Women
NCT05329779
Recruiting
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
Female
Ages:
Between 40 years and 60 years
Trial Updated:
11/08/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
Register for Updates