There are currently 2699 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications
NCT04229368
Recruiting
Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce postoperative complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
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The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
NCT05258981
Recruiting
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).
Gender:
ALL
Ages:
Between 24 years and 35 years
Trial Updated:
08/14/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease
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A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
NCT04143659
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Boston Medical Center Corporation, Boston, Massachusetts
Conditions: Healthy Women, Female Contraception
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Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT00499317
Recruiting
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes of which some remain unknown. It is believed that some types of CP may be genetic or passed down (inherited) from one generation to the next. In this study, we are collecting genetic material and medical information to try to determine if genetic factors play a role in CP/CPPS. We will be collecting DNA (from Blood/Saliva sample) and urine from each participant. Bladder tissue from affected individuals... Read More
Gender:
MALE
Ages:
All
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital (BCH), Boston, Massachusetts
Conditions: Chronic Prostatitis (CP), Chronic Pelvic Pain Syndrome (CPPS), Painful Bladder Syndrome (PBS), Benign Frequency Syndrome (BFS), Interstitial Cystitis
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Preterm Lung Patient Registry
NCT00951366
Recruiting
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival. The Patient Registry was established in 2008 as a means to monitor important trends in the BPD population and to improve understanding, treatment, and survival.
Gender:
ALL
Ages:
All
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Disease
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MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
NCT01788410
Recruiting
The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root. The goal is to provide palliative care with superior efficacy and longer relief compared to current methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Facet Joints; Degeneration, Neuropathy, Neuralgia
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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
NCT04557891
Recruiting
There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdala. In this double-blind sham-controlled clinical trial, the investigators propose to establish baseline severity of anxiety in 48 patients, then deliver eight treatments over four sessions of focused... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/04/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Generalized Anxiety Disorder
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Feasibility of [11C]Acetate-PET in LAM and TSC
NCT05467397
Recruiting
This study aims to assess \[11C\]acetate positron emission tomography (PET)/computed tomography (CT) as a biomarker for renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM) and an early biomarker of response to rapamycin in LAM patients. \[11C\]Acetate is a radioactive form of acetate, a nutrient commonly processed in our body's cells to generate fat and energy. Preclinical studies support the hypothesis that TSC tumors enhance lipid synthesis compared to normal tissues, suggestin... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Lymphangioleiomyomatosis, Tuberous Sclerosis Complex
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COVID-19-Related Opioid Treatment Policy Evaluation
NCT05028998
Recruiting
Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT. In MAT, patients receive a medication that reduces cravings and withdrawal symptoms and can prevent overdose. Patients also receive counseling. Because the medications that are used in MAT are controlled substances, this treatment is subject to a number of federal regulations. The need for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Opioid-use Disorder, Alcohol Use Disorder
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Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
NCT05976659
Recruiting
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD) in the context of dementia.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/27/2023
Locations: Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts
Conditions: Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases, Memory Disorders, Depressive Disorder
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Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects
NCT02416674
Recruiting
Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a deceased human donor to a patient with a large abdominal wall defect. Abdominal wall transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with large abdominal wall defects. The purpose of this study is to develop the best practices for abdominal wall transplantation that will improve the outcomes of future abdominal wall transplant rec... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Abdominal Wall Defect
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