There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.
NCT02075775
Recruiting
This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI outcome measures, as well as demographic and socioeconomic information. Surgeons will complete a form after surgery with information on radiogra... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
11/07/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Other Instability, Shoulder, Dislocations, Subluxations, Recurrent Dislocation of Shoulder Region
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PEERS Plus mHealth Enhanced Peer Support
NCT05611996
Recruiting
The goal of this intervention study is to design and learn whether peer support that is delivered through video chats and texting can decrease depression among older adults. Participants will be assigned to a peer support program where they will receive 8 video chats with a peer mentor who provide social support and supportive texts over 8 weeks.
Gender:
All
Ages:
50 years and above
Trial Updated:
11/03/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Depression in Old Age
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Pain in Long COVID - The Role of Sleep
NCT05606211
Recruiting
Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/02/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Long COVID, No Long COVID
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Renal Mechanism of SGLT2 Inhibition
NCT05507892
Recruiting
Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing salt and sugar loss in the urine, and has shown to protect heart, kidney, and blood vessel function in patients with type 2 diabetes. However, it is unknown how canagliflozin protects the kidneys from disease. Therefore, this study plans to learn more about how canagliflozin works to protect against diabetic kidney disea... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/31/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Type 2 Diabetes, Diabetic Kidney Disease
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Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve
NCT05605951
Recruiting
The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including cli... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2022
Locations: Harvard Medical School, Boston, Massachusetts
Conditions: Demyelinating Diseases, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Optic Neuritis
Register for Updates
Therapeutic Contact Lens Drug Delivery System (TCL-DDS) in Patients With Recurrent Cystoid Macular Edema
NCT04225611
Recruiting
The main aim of the pilot study is to determine preliminary estimates of the safety, tolerability, and comfort of a dexamethasone-eluting therapeutic contact lens drug delivery system (TCL-DDS) for the treatment of recurrent cystoid macular edema. Secondarily, feasibility of the TCL-DDS system will be investigated. Safety: To establish that a topical dexamethasone delivery system has an acceptable safety profile by determining the incidence and severity of ocular adverse events, as identified b... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/27/2022
Locations: MEEI, Boston, Massachusetts
Conditions: Cystoid Macular Edema
Register for Updates
A Mobile Tai Chi Platform for Fall Prevention and Cognition in Older Adults
NCT05209464
Recruiting
The investigators will assess feasibility and acceptability of the Tele-Tai Chi (TC) intervention; explore changes in clinically relevant outcome measures including: physical activity, self-efficacy, quality of life, cognitive function, balance, gait, and evaluate changes in TC proficiency. To achieve this, the investigators are running a single-arm study for older adults that involves a 12-week home-based Tai Chi intervention. Study participation includes four remote and/or in-person (at Spauld... Read More
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
10/25/2022
Locations: Spaulding Rehabilitation Hospital, Boston, Massachusetts
Conditions: Aging, Fall
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Transplanting Hepatitis C Positive Organs
NCT03086044
Recruiting
This is an open-label, pilot safety and efficacy trial for adults who are active on the heart, lung, or kidney transplantation lists and are eligible to receive an organ from an increased risk donor who has evidence of active or prior hepatitis C infection (HCV).
Gender:
All
Ages:
18 years and above
Trial Updated:
10/10/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hepatitis C, Awaiting Organ Transplant
Register for Updates
The Genomic Medicine at VA Study
NCT04331535
Recruiting
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
Gender:
All
Ages:
Between 50 years and 70 years
Trial Updated:
09/29/2022
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer
Register for Updates
Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases
NCT04825067
Recruiting
In this project, Institute of Bioengineering & Bioimaging (IBB), A*STAR would like to collaborate with Massachusetts General Hospital to aggregate patient data and to further develop its software algorithm using machine learning and statistical models for predicting exacerbations and deterioration on 60 patients with cardiopulmonary diseases.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2022
Locations: Integrated Care Management Program, Boston, Massachusetts
Conditions: Congestive Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, Cystic Fibrosis
Register for Updates
Effectiveness of a Walking Intervention on Impact Loading and Pain
NCT04148807
Recruiting
This study investigates the feasibility of a gait-retraining program for older adults with knee osteoarthritis. The study will enroll 40 participants, with 20 receiving a gait retraining intervention and 20 receiving a graded walking program without gait retraining.
Gender:
All
Ages:
45 years and above
Trial Updated:
09/27/2022
Locations: Northeastern University, Boston, Massachusetts
Conditions: Osteoarthritis, Knee, Knee Pain Chronic
Register for Updates
Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile
NCT05389904
Recruiting
Clostridioides difficile (C. difficile) is the most common healthcare-associated pathogen, causing >500,000 infections and >29,000 deaths per year in the US. Traditional approaches to reduce hospital-onset CDI focus on identifying, isolating, and treating symptomatic patients to prevent transmission to other patients. Recent genomic epidemiology studies, however, suggest that most hospital-onset CDI cases are attributable to asymptomatic carriers who either progress from colonization to active i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/23/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: C. Difficile
Register for Updates