RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Pain
Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain
Recruiting
This study will use a randomized controlled design to test whether medical marijuana use by adults on high-dose chronic opioid therapy (COT) for chronic non-cancer pain is associated with reduced opioid dose and improved pain intensity and interference when added to a 24-week behavioral intervention (POTS).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/16/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Opioid Use, Pain, Marijuana Use
Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
Recruiting
The aim of this study is to assess whether IW-3300 is safe and works for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). The main question the study aims to answer is whether IW-3300 helps bladder pain and other symptoms (for example, bladder burning, pressure and discomfort). Subjects will be assigned to receive either the study drug or placebo by chance.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/15/2023
Locations: Bay State Clinical Trials, Watertown, Massachusetts
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
Feasibility of Remote Tai Chi
Recruiting
In the proposed trial, the investigators plan to refine interventions, then conduct a small randomized trial to provide critical information to inform a future large-scale randomized efficacy trial of Tai Chi for Post Traumatic Stress Disorder (PTSD) and chronic pain. Building on the combined experience the proposed study will progress in new directions to: Adapt, refine, and standardize two 12-week treatment protocols (Tai Chi and a Wellness control condition) for Veterans diagnosed with PTSD... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: PTSD, Pain, Chronic
A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease
Recruiting
This study is an open-label study to evaluate the safety of long-term administration of inclacumab in participants with sickle cell disease (SCD). Participants in this study will have completed a prior study of inclacumab.
Gender:
All
Ages:
12 years and above
Trial Updated:
11/13/2023
Locations: Brigham And Woman's Hospital, Boston, Massachusetts +2 locations
Conditions: Sickle Cell Disease, Vaso-occlusive Crisis, Vaso-occlusive Pain Episode in Sickle Cell Disease
Pain Reduction With Topical Bromfenac Versus Artificial Tear After Intravitreal Injection.
Recruiting
The purpose of this prospective interventional study is to compare post-intravitreal injection pain between eyes receiving topical bromfenac versus artificial tears as an analgesic after intravitreal injection.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
11/08/2023
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Pain, Intravitreal Injection, Pain, Acute
Study of BOTOX Injections to Assess Change in Disease Activity and Adverse Events in Adult Female Participants With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Recruiting
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic and debilitating urological complex of disorders characterized by symptoms of bladder pain or discomfort, mostly upon bladder filling, and often accompanied by lower urinary tract symptoms (LUTS). This study will assess how safe and effective BOTOX (onabotulinumtoxinA) is in treating IC/BPS. Adverse events and change in disease symptoms will be evaluated. BOTOX (onabotulinumtoxinA) is an investigational drug being developed for t... Read More
Gender:
Female
Ages:
Between 18 years and 75 years
Trial Updated:
10/31/2023
Locations: Bay State Clincial Trials, Inc /ID# 240848, Watertown, Massachusetts
Conditions: Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: MGH Department of Anesthesia, Critical Care, and Pain, Boston, Massachusetts
Conditions: Painful Diabetic Neuropathy
EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
Recruiting
The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 weeks.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: MGH Department of Anesthesia, Critical Care, and Pain, Boston, Massachusetts
Conditions: Painful Diabetic Neuropathy
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Boston Clinical Trials, Boston, Massachusetts +2 locations
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: MedVadis Research Corporation, Waltham, Massachusetts
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Recruiting
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.
Gender:
All
Ages:
Between 11 years and 17 years
Trial Updated:
10/18/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Chronic Widespread Pain, Stress, Psychological, Stress, Physiological