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Pain Paid Clinical Trials in Massachusetts
A listing of 77 Pain clinical trials in Massachusetts actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 77
The state of Massachusetts currently has 77 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Recruiting
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone).
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use, Pain, Hypogonadism, Male
Telehealth for Pain and Unhealthy Drinking Among PLWH
Recruiting
This randomized controlled trial is a between-groups design to compare the Motivational and Cognitive Behavioral Management for Alcohol and Pain (MCBMAP) Intervention to a Brief Advice and Information Control condition.
Two-hundred and fifty participants who have HIV with moderate or greater chronic pain will be randomized for the trial. Recruitment will take place through digital media. A unique feature of this intervention trial is that most of the procedures will be conducted remotely which... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2025
Locations: Charles River Campus, Boston University, Psychology Department- remote study, Boston, Massachusetts
Conditions: HIV, Chronic Pain, Unhealthy Alcohol Use
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use
- and -
To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Pain
Brief Intervention for Chronic Pain and History of Stressful Experiences
Recruiting
The goal of this study is to understand whether a brief, three session program can be helpful in reducing symptoms related to both chronic pain and stressful experiences/trauma.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/06/2025
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Chronic Pain, Trauma, Adverse Childhood Experiences
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Recruiting
Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer, post-traumatic stress disorder, and depression. Studies have also demonstrated that even in healthy adults, the presence of dogs is associated with physiologic changes such as increased pain threshold, decreased blood pressure, and decreased heart rate. However, few studi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/05/2025
Locations: Boston Medical Center, Trauma Inpatient Service, Boston, Massachusetts
TENS Unit for Analgesia During IUD Insertion
Recruiting
Subjects will be screened over the phone or in Tufts GYN clinic for participation in the study. If eligible and interested in participating, written informed consent (and assent if applicable) will be obtained. After informed consent/assent, the patient will be enrolled in the study. The patient will decide if they desire to use TENS unit during IUD insertion appointment and inform the study team. The clinic visit will proceed as normal, with additional study proceedings as follows. The study pe... Read More
Gender:
FEMALE
Ages:
Between 12 years and 50 years
Trial Updated:
06/03/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: IUD, Analgesia, Patient Preference, Pain, Acute
Adolescent Outcomes of Post-operative Opioid EXposure
Recruiting
The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associated with risk factors for opioid use disorder (ROUD) in the 12 months following major surgery with opioid exposure among adolescents aged 12-17. Participants will be asked to complete electronic surve... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
05/29/2025
Locations: Boston Childrens Hopsital - Division of Addiction Medicine, Boston, Massachusetts
Conditions: Opioid Use Disorder, Pain, Chronic
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Recruiting
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs. standard pain management plus up to 6 weeks of NSAIDs (Group 2) in the treatment of tibial shaft fractures.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/27/2025
Locations: Harvard Medical Center, Cambridge, Massachusetts
Conditions: Tibial Fractures, Pain
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
Recruiting
The purpose of this study is to evaluate how safe and how well a treatment works compared to placebo for people with nerve pain that begins in their feet and moves up the leg to just below the knee.
Participation may last up to 30 weeks including screening.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Lucida Clinical Trials, New Bedford, Massachusetts
Conditions: Neuropathic Pain, Distal Sensory Polyneuropathy
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Recruiting
The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active Living Every Day (ALED). The investigators will assess how each program may help in improving physical, cognitive, and emotional function. The investigators will also assess whether improvements in out... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Boston Clinical Trials, Boston, Massachusetts +3 locations
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Glycemic Regulation as Endometriosis Adjunct Treatment
Recruiting
The goal of this pilot trial is to learn if a novel non-hormonal treatment, metformin hydrochloride, works to treat pelvic pain in young women with endometriosis. The main questions it aims to answer are:
* Is metformin superior to placebo in alleviating pain symptoms in young women with endometriosis?
* Does metformin alter systemic inflammatory markers over 6 months in young women with endometriosis?
Researchers will compare metformin to a placebo (a look-alike substance that contains no dru... Read More
Gender:
FEMALE
Ages:
Between 15 years and 35 years
Trial Updated:
05/22/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pelvic Pain, Endometriosis
1 - 12 of 77