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Durham, NC Paid Clinical Trials
A listing of 934 clinical trials in Durham, NC actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
25 - 36 of 934
There are currently 934 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University health system. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Investigational Combined COVID-19 and Influenza Vaccine
Recruiting
This study aims to evaluate the safety, immune response, and tolerability of an investigational vaccine designed to protect against both COVID-19 and seasonal influenza in adults aged 18 to 64 years. Participants will be randomly assigned to receive the investigational vaccine or a currently available vaccine. The study involves a single vaccination followed by monitoring over several months. Should you express interest, the research site will contact you directly to provide further details and address any questions you may have about study requirements, risks/benefits, and compensation.
Conditions:
Interested in vaccine studies
All Conditions
Healthy
Preventative Trials
Featured Trial
Investigational Stomach Flu Vaccine
Recruiting
The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.
Conditions:
Interested in vaccine studies
All Conditions
Preventative Trials
Healthy
Age 60+
Featured Trial
Healthy Volunteer Oral COVID-19 Preventative Drug
Recruiting
The main objectives of this study are to assess the safety, effectiveness, and immune response of an investigational oral preventative drug (oral vaccination) in preventing COVID-19 and its symptoms. Participants will be randomly assigned to receive the investigational oral vaccine or a currently available market COVID-19 vaccine. Should you express interest, you will be contacted directly by the research site, who will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.
Conditions:
Preventative Trials
Healthy
All Conditions
Interested in vaccine studies
Healthy Volunteers
Featured Trial
High Triglyceride Clinical Research Study
Recruiting
Living with high triglycerides? See if our clinical study is right for you.
Don’t let financial stress hold you back. All clinical study-related assessments, care, and the investigational study drug are available at no cost. You could also be eligible for compensation for travel.
Don’t let financial stress hold you back. All clinical study-related assessments, care, and the investigational study drug are available at no cost. You could also be eligible for compensation for travel.
Conditions:
High Triglycerides
High Triglyceride Level
Hypertriglyceridemia
Elevated Triglycerides
Triglycerides High
Featured Trial
Studying an Investigational Treatment in Children with Type 2 Diabetes
Recruiting
The main objectives of this study are to confirm the effectiveness and safety of an investigational treatment in adolescents and children with type 2 diabetes. The study will also assess whether the investigational treatment can improve glucose control and reduce body weight. Participants will be randomly assigned to receive either the investigational treatment or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.
Conditions:
Pediatric
Type 2 Diabetes (T2DM)
Adolescent Trials
All Conditions
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Recruiting
Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. This study tests high-speed optical coherence tomography (OCT) technology compared to conventional color photographs at the bedside of very preterm infants in the intensive care nursery, to characterize previously unseen abnormalities that can predict a need for referral for ROP treatment, or poor visual or neurological devel... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/13/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Retinopathy of Prematurity
Development & Validation of Preoperative Objective Physiological Evaluation
Recruiting
This study will compare the measured oxygen consumption (VO2) obtained during sub-maximal exercise testing with the estimated VO2 derived from a non-exercise questionnaire.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: Cardiorespiratory Fitness
DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain MetAstaSEs
Recruiting
The purpose of this study is to test the safety and effectiveness of the study drug datopotamab deruxtecan in participants with metastatic breast cancer that has spread to the brain.
The name of the study drug used in this research study is:
Datopotamab deruxtecan (a type of antibody-drug conjugate)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Breast Cancer, Breast Cancer Female, Metastatic Triple-Negative Breast Carcinoma, ER Positive Breast Cancer, HER2-negative Breast Cancer, HER2 Negative Breast Carcinoma, ER-negative Breast Cancer
Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial
Recruiting
This phase II ComboMATCH treatment trial tests the usual treatment of chemotherapy (paclitaxel) plus ipatasertib in patients with solid tumor cancers that that cannot be removed by surgery (unresectable), has spread to nearby tissue or lymph nodes (locally advanced) or from where it first started (primary site) to other places in the body (metastatic), and has PTEN and AKT genetic changes. Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm
A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features
Recruiting
This is a Phase III, randomised, open-label, multicentre, global study assessing the efficacy and safety of adjuvant Dato-DXd in combination with rilvegostomig compared with SoC, after complete surgical resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive, as determined by the Sponsor-designated ctDNA assay, or have at least one high-risk pathological feature.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Research Site, Durham, North Carolina
Conditions: Non-small Cell Lung Cancer
A Phase 2 Study of Home Care Following Autologous Hematopoietic Stem Cell Transplantation
Recruiting
This is a research study to compare the well-being (caregiver strain index) of caregivers of patients receiving home vs standard care after autologous hematopoietic stem cell transplant.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Well-being of Caregivers (Caregiver Strain Index)
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
Recruiting
ACTEMRA (tocilizumab) is an IL-6 receptor antagonist used for the treatment of adult Rheumatoid Arthritis as well as Polyarticular (PJIA) and Systemic (SJIA) Juvenile Idiopathic Arthritis. In this Phase II, the drug will be used to treat pediatric patients diagnosed with recurrent Adamantinomatous Craniopharyngioma including patients who have undergone surgery and/or radiation therapy.
Gender:
ALL
Ages:
Between 1 year and 39 years
Trial Updated:
03/13/2025
Locations: Duke Children's Hospital, Durham, North Carolina
Conditions: Adamantinomatous Craniopharyngioma, Recurrent Adamantinomatous Craniopharyngioma
A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa
Recruiting
This is a phase 1b/2 study of a single dose of intravenous (IV) bacteriophage in males and non-pregnant females, at least 18 years old, diagnosed with Cystic Fibrosis (CF). This clinical trial is designed to assess the safety and microbiological activity of bacteriophage product Walter Reed Army Institute of Research- PAM-Cystic Fibrosis1 (WRAIR-PAM-CF1), directed at Pseudomonas aeruginosa in clinically stable CF individuals chronically colonized with P. aeruginosa. WRAIR-PAM-CF1 is a 4 componen... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Bacterial Disease Carrier, Cystic Fibrosis
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs)
Recruiting
The goal of this observational study is to utilize a novel imaging system designed for high-resolution retinal imaging of neonates, infants and children to identify the signs of photoreceptor development and degeneration in children with early-onset inherited retinal dystrophies (EORDs). Participants will have research imaging with SS-HH-OCT at the time of clinically-indicated eye examinations or procedures. The investigators aim to establish the basis for utilization of OCT imaging in earlier d... Read More
Gender:
ALL
Ages:
Between 0 years and 8 years
Trial Updated:
03/13/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Retinal Dystrophies
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Recruiting
The main objective of the study is to evaluate the efficacy of satralizumab compared with placebo based on time from randomization to the first occurrence of an adjudicated MOGAD relapse in the double-blind (DB) treatment period
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immunotherapy in Genitourinary Malignancies (CTC Immune Based Biomarkers)
Recruiting
This pilot study purpose of this study is to describe peripheral circulating immune cell profiles at baseline and change on treatment with immune checkpoint inhibitors in renal cell carcinoma and urothelial carcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Carcinoma, Renal Cell, Carcinoma, Urothelial
Automated Applanation Tonometry
Recruiting
Goldmann Applanation Tonometry (GAT) is considered the clinical gold standard for eye pressure measurements and yet it is known to be a subjective measurement with limited repeatability and limited portability. The purpose of this study is to develop an automated and objective method for performing applanation tonometry using standard ophthalmic equipment as well as using 2 portable prototypes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/13/2025
Locations: Duke Eye Center, Durham, North Carolina
Conditions: Glaucoma, Glaucoma, Suspect
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