There are currently 931 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University Health System. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Cancer Peptides Plus GM-CSF and Adjuvant in Breast Cancer
NCT04270149
Recruiting
This is a phase I study looking at the safety of cancer peptides combined with adjuvant and GM-CSF in subjects with estrogen receptor (ESR) positive breast cancer. The primary objective of the study is to determine the safety of of the peptide vaccine. The secondary objective is to evaluate the immune response to the vaccine. The peptides used in this vaccine are derived from the estrogen receptor and are combined with the adjuvant Montanide ISA and GM-CSF to enhance their immune response. A pep... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Breast Cancer
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Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
NCT05327062
Recruiting
The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by integration of 3D images from 3D activation sequence from ECG, and coronary venous anatomy from cardiac computed tomography. This CRT-roadmap will be used to guide LV lead placement to a coronary vein in an electrically late-activated region. Study Hypothesis: At least 75% of patients undergoing a CR... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
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Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
NCT06271265
Recruiting
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 to less than 6 years of age undergoing cardiac surgery, utilizing local infiltration analgesia (LIA).
Gender:
ALL
Ages:
Between 0 years and 6 years
Trial Updated:
10/22/2024
Locations: Duke University Health System, Durham, North Carolina
Conditions: Postoperative Pain
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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
10/21/2024
Locations: Duke University, Durham, North Carolina
Conditions: Heart Failure With Preserved Ejection Fraction
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Rectus Sheath Block for Analgesia After Gynecological Laparotomy
NCT06575699
Recruiting
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml bupivacaine 0.25% per side. Cases will be matched in a 1:2 ratio by age, race, insurance status and duration of surgery with historical controls who received postoperative analgesia using thoracic epidural analgesia.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Gynecologic Surgical Procedures
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ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
NCT06141993
Recruiting
This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin to spread, they may release cells into patients' bloodstream. These cells are called "circulating tumor cells", or CTCs. CTCs can be used to look for differences in "biomarkers" (genes or proteins tha... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
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Mobile Neurofeedback for Low Back Pain
NCT05669027
Recruiting
The purpose of this study is to learn more about improving the quality of treatments for people who have chronic low back pain. Participants will complete interviews with Duke researchers at four different time points: the beginning of the study, at 3 months, at 6 months, and at 9 months. Participants will be asked to use a mobile app and a headset that are designed to train the brain to be more relaxed. Participants will use the mobile app for 10 minutes at a time, four times a week for three m... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/09/2024
Locations: Duke University Medical Center, Department of Psychiatry, Durham, North Carolina
Conditions: Chronic Low Back Pain
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Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
NCT04657146
Recruiting
The main goal of this study is to provide foundational data to drive translational approaches for an entirely novel category of immunotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glioblastoma
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Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
NCT05055830
Recruiting
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating provider. The purpose of this study is to characterize the PK of drugs routinely administered to children per standard of care using opportunistic and scavenged samples. The prescribing of drugs to children will not be part of this protocol. After the child/adult (\<21 years of... Read More
Gender:
ALL
Ages:
Between 0 months and 20 years
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cardiac Disease, Critically Ill, Children, Adult
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Imaging Retinal Vasculature in Infant Eyes
NCT05558059
Recruiting
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants,... Read More
Gender:
ALL
Ages:
2 months and below
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Retinopathy of Prematurity
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Sling vs No Sling After Reverse Total Shoulder Arthroplasty
NCT06092996
Recruiting
This study involves patients who will be undergoing a reverse total shoulder replacement at Duke University. 100 eligible will be randomly assigned into one of two groups, a sling or no sling group. Patients in the sling group will wear a sling for three weeks after their surgery while the no sling group will only wear a sling three days after their surgery. Patients will follow their doctors normal follow up visit schedule after surgery, with visits at 2 weeks, 6 weeks, 3 months, 6 months, 1 ye... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Disease, Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
Register for Updates