There are currently 933 clinical trials in Durham, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Duke University Medical Center, Duke University, Duke Comprehensive Cancer Center and Duke University Health System. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
NCT06575699
Recruiting
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml bupivacaine 0.25% per side. Cases will be matched in a 1:2 ratio by age, race, insurance status and duration of surgery with historical controls who received postoperative analgesia using thoracic epidural analgesia.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Gynecologic Surgical Procedures
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ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials
NCT06141993
Recruiting
This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin to spread, they may release cells into patients' bloodstream. These cells are called "circulating tumor cells", or CTCs. CTCs can be used to look for differences in "biomarkers" (genes or proteins tha... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
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Mobile Neurofeedback for Low Back Pain
NCT05669027
Recruiting
The purpose of this study is to learn more about improving the quality of treatments for people who have chronic low back pain. Participants will complete interviews with Duke researchers at four different time points: the beginning of the study, at 3 months, at 6 months, and at 9 months. Participants will be asked to use a mobile app and a headset that are designed to train the brain to be more relaxed. Participants will use the mobile app for 10 minutes at a time, four times a week for three m... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/09/2024
Locations: Duke University Medical Center, Department of Psychiatry, Durham, North Carolina
Conditions: Chronic Low Back Pain
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Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
NCT04657146
Recruiting
The main goal of this study is to provide foundational data to drive translational approaches for an entirely novel category of immunotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glioblastoma
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Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
NCT05055830
Recruiting
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating provider. The purpose of this study is to characterize the PK of drugs routinely administered to children per standard of care using opportunistic and scavenged samples. The prescribing of drugs to children will not be part of this protocol. After the child/adult (\<21 years of... Read More
Gender:
ALL
Ages:
Between 0 months and 20 years
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cardiac Disease, Critically Ill, Children, Adult
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Imaging Retinal Vasculature in Infant Eyes
NCT05558059
Recruiting
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants,... Read More
Gender:
ALL
Ages:
2 months and below
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Retinopathy of Prematurity
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Sling vs No Sling After Reverse Total Shoulder Arthroplasty
NCT06092996
Recruiting
This study involves patients who will be undergoing a reverse total shoulder replacement at Duke University. 100 eligible will be randomly assigned into one of two groups, a sling or no sling group. Patients in the sling group will wear a sling for three weeks after their surgery while the no sling group will only wear a sling three days after their surgery. Patients will follow their doctors normal follow up visit schedule after surgery, with visits at 2 weeks, 6 weeks, 3 months, 6 months, 1 ye... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Disease, Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
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Optimize Pediatric OCT Imaging
NCT06139523
Recruiting
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an investigational noncontact OCT system (Duke Biomedical Engineering) to assess their ability to image the pediatric retina. The investigators hypothesize that the contact OCT system is superior in imaging larger areas of the retina (larger field-of-view), while it has similar resolut... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/08/2024
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Retinal Disease, Glaucoma, Optic Nerve Diseases
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Chlorhexidine Gluconate Bathing Education Video Among Hospitalized Patients
NCT06112626
Recruiting
Chlorhexidine gluconate (CHG) bathing is an effective intervention to reduce hospitalized patient's risk of acquiring a central line-associated bloodstream infection (CLABSI). While daily CHG bathing for hospitalized patients is widely supported in the literature, patient adherence with this practice is suboptimal. Written and verbal information is provided to patients by nursing staff regarding the importance of CHG bathing and the correct usage of the CHG cloths; however, these methods can be... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/03/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Infections
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A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
NCT05885412
Recruiting
This Phase 1 dose escalation trial will assess the safety and preliminary efficacy of a single dose intravenous infusion of RP-A601 in high-risk adult patients with PKP2-ACM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: Duke University, Durham, North Carolina
Conditions: PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
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Aimovig Pregnancy Exposure Registry
NCT06150781
Recruiting
The primary objective of this study is to estimate the proportion of major congenital malformations in infants of women with migraine exposed to erenumab-aooe during pregnancy compared to infants of women with migraine unexposed to erenumeb-aooe.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
10/02/2024
Locations: IQVIA Virtual Site, Durham, North Carolina
Conditions: Migraine
Register for Updates