Oregon is currently home to 1212 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Portland, Eugene, Medford and Clackamas. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
OCT Angiography and NRAI in Dementia
NCT03761381
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Alzheimer Disease, Dementia, Mild Cognitive Impairment
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Collagen Cross-linking in Keratoconus
NCT03760432
Recruiting
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Keratoconus
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OCT Angiography in Wet AMD
NCT02253030
Recruiting
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2. evaluate patients undergoing treatment for wet AMD 3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Neovascular (Wet) Age-related Macular Degeneration (AMD)
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OCT in Rare Chorioretinal Diseases
NCT02141308
Recruiting
This study will evaluate the total blood flow in the retina and choroid (structures in the back of the eye) by Doppler optical coherence tomography (OCT) and OCT angiography. Angiography is mapping of the blood vessels. The purpose of measuring blood flow in the retina and choroid is to 1.) determine if rare diseases in these structures causes a change in blood flow compared to healthy eyes and 2.) find out if areas of changed blood flow line up with areas of damage that appear on conventional... Read More
Gender:
ALL
Ages:
Between 7 years and 100 years
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Retinal Artery Occlusions, Polypoidal Choroidal Vasculopathy, Retinal Arterial Macroaneurysm, Juxtafoveal Telangiecasia, Central Serous Chorioretinopathy
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Observational Study of Corneal Opacities in Adults
NCT02109471
Recruiting
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/08/2024
Locations: Humberto Martinez, Portland, Oregon
Conditions: Corneal Opacities (Scar and Stromal Dystrophy)
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Optical Coherence Tomography (OCT) in Uveitis
NCT02026128
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer (one one-thousandths) scale imaging of biological tissue. This allows excellent assessment of the white blood and inflammatory cells seen in uveitis, an inflammation of any or all parts of the uvea (iris, ciliary body, choroid).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Uveitis
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Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
NCT01243931
Recruiting
Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this study is to determine whether OCT-guided settings for the lasers used for removal of corneal scars and other partial-thickness corneal defects result in improved vision in patients receiving these procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Corneal Opacity
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Intraocular Lens Power Calculation After Laser Refractive Surgery Based on Optical Coherence Tomography
NCT00532051
Recruiting
The long-term goal of this project is to utilize very high-speed optical coherence tomography (OCT) technology to guide surgical treatments of corneal diseases. OCT is well known for its exquisite resolution, but until recently it has not had sufficient speed to capture the shape of the cornea because of eye motion during OCT scanning. The development of Fourier-domain (FD) OCT technology has made the requisite speed possible. The objective of this project is to develop methods for imaging the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon
Conditions: Cataract
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The Acute Burn ResUscitation Multicenter Prospective Trial
NCT04356859
Recruiting
This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: Legacy Health, Portland, Oregon
Conditions: Burn Injury
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A Study of AT-02 in Subjects With Systemic Amyloidosis.
NCT05951049
Recruiting
This is a Phase 2 open-label extension study to evaluate the long-term safety, tolerability, and clinical activity of AT-02. AT-02 is an investigational medicinal product being developed to treat systemic amyloidosis.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/29/2024
Locations: OHSU (Oregon Health & Science University), Portland, Oregon
Conditions: Amyloidosis; Systemic
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Subscapularis Repair in Reverse Shoulder Arthroplasty
NCT05438914
Recruiting
This study will evaluate the subscapularis repair versus non-repair during a reverse shoulder arthroplasty (RSA).
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/29/2024
Locations: Southern Oregon Orthopedics, Medford, Oregon
Conditions: Rotator Cuff Tear Arthropathy
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Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
NCT01013714
Recruiting
The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to sudden cardiac death. Subjects will be asked to participate in this research study if they have recurrent ventricular tachycardia (at least one ICD shock for ventricular tachycardia) and have undergone at least one catheter ablation procedure or have ventricular tachycard... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: OHSU, Portland, Oregon
Conditions: Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
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