South Carolina is currently home to 1231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
NCT02915198
Recruiting
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in patients who have pre-diabetes and heart or blood vessel problems.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Prediabetic State, Atherosclerosis, Metformin
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A Study to Evaluate EDP 938 Regimens in Children With RSV
NCT04816721
Recruiting
A 2-part study to evaluate the safety, pharmacokinetics and efficacy of EDP-938 in children with RSV infection.
Gender:
All
Ages:
Between 28 days and 36 months
Trial Updated:
01/04/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Respiratory Syncytial Virus (RSV)
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Oxytocin to Enhance Integrated Treatment for AUD and PTSD
NCT04523922
Recruiting
The primary objective of the proposed Stage II study is to examine the efficacy of oxytocin (OT) as compared to placebo in reducing (1) alcohol use disorder (AUD) symptoms, and (2) post-traumatic stress disorder (PTSD) symptoms among Veterans receiving COPE therapy (Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure). To evaluate purported neurobiological mechanisms of change, we will employ functional magnetic resonance imaging (fMRI) at pre- and post-treatment.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/04/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: PTSD, Alcohol Use Disorder
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Encore PFO Closure Device - The PerFOrm Trial
NCT05537753
Recruiting
The objective of this study is to establish reasonable assurance of safety, effectiveness, and noninferiority of the Encore PFO closure device when compared to any investigator chosen FDA-approved PFO closure device.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/03/2024
Locations: Medical University of South Carolina Gazes Research Institute, Charleston, South Carolina
Conditions: Patent Foramen Ovale, Cryptogenic Stroke
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Motivational Interviewing to Address Suicidal Ideation for Veterans at High Risk for Suicide
NCT05256940
Recruiting
The purpose of this project is to conduct a randomized control trial with 470 Veterans to examine the impact of a revised version of Motivational Interviewing to Address Suicidal Ideation (MI-SI-R) on risk for suicide attempts and suicidal ideation when compared to high quality usual care.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Suicide, Attempted, Suicidal Ideation
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Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis
NCT05403541
Recruiting
The purpose of this 4-period study is to confirm the efficacy and safety of batoclimab in participants with gMG. In Period 1, participants will be randomized 1:1:1 to receive batoclimab 680 milligrams (mg) subcutaneously (SC) once a week (QW) or 340 mg SC QW or placebo. The primary efficacy endpoint will be assessed by change in the myasthenia gravis activities of daily living (MG- ADL) score in acetylcholine receptor antibody seropositive (AChRAb+) participants. In Period 2, participants previo... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Site Number - 1030, Charleston, South Carolina
Conditions: Generalized Myasthenia Gravis
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Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
NCT04429542
Recruiting
The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina
Conditions: Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal, Colorectal Cancer, Squamous Cell Carcinoma of the Lung, EGFR Amplification, Epithelial Ovarian Cancer, Pancreas Cancer, Cutaneous Squamous Cell Carcinoma, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Squamous Cell Carcinoma of Head and Neck
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Pulmonary Hemodynamics During Exercise - Research Network
NCT03954574
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pulmonary Circulation Diseases
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Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis With Fibrosis
NCT05011305
Recruiting
Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/30/2023
Locations: Zydus US015, Charleston, South Carolina
Conditions: Nonalcoholic Steatohepatitis, Fibrosis
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BlueWind RENOVA iStim™ System for the Treatment of OAB
NCT03596671
Recruiting
The OASIS study is prospective, interventional, multi-center study to evaluate the safety and efficacy of the BlueWind RENOVA iStim™ implantable tibial neuromodulation System for the treatment of patients diagnosed with overactive bladder.
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
12/29/2023
Locations: Southern Urogynocology, West Columbia, South Carolina
Conditions: Treatment of Patients Suffering From Overactive Bladder (OAB)
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Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms
NCT05636124
Recruiting
This is a multi-center, prospective, propensity matched twin armed study conducted on 50 patients in the experimental arm followed for 18 months after intervention evaluating cost effectiveness, safety and efficacy of therapy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/21/2023
Locations: Prisma Health, Greenville, South Carolina
Conditions: Intracranial Aneurysms, Wide Neck Intracranial Aneurysms
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Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392
Recruiting
Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect
Gender:
All
Ages:
84 years and below
Trial Updated:
12/21/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases, Congenital Abnormalities
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