South Carolina is currently home to 1165 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Columbia and Spartanburg. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RM1 Project 2 - tAN fMRI
NCT05487664
Recruiting
In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone.... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/09/2024
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Auricular Stimulation
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Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System
NCT03831386
Recruiting
Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop discomfort and chest pain during drainage. The investigators propose to evaluate gravity drainage and suction drainage on quality of life measures and outcom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pleural Effusion
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US National OCS Heart Perfusion (OHP) Registry
NCT05915299
Recruiting
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Heart Transplant
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Blood Warming in Preterm Infants to Decrease Hypothermia
NCT05170633
Recruiting
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by The World Health Organization. Another acute morbidity is anemia in preterm infants due to the prematurity and frequent laboratory testing. Anemia requires correction with a packed red blood cells (PRBC... Read More
Gender:
ALL
Ages:
Between 24 weeks and 32 weeks
Trial Updated:
12/05/2024
Locations: Kayla Everhart, Columbia, South Carolina
Conditions: Preterm Birth, Blood Transfusion Complication, Hypothermia
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Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
ALL
Ages:
Between 1 year and 120 years
Trial Updated:
12/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
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The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
NCT04171323
Recruiting
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
12/05/2024
Locations: Clemson University, Seneca, South Carolina
Conditions: Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
NCT05059444
Recruiting
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and explore its value in a healthcare environment subject to cost containment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: Carolina Blood and Cancer Care Associates, Rock Hill, South Carolina
Conditions: Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer, Invasive Breast Carcinoma, Cutaneous Melanoma, Esophageal Carcinoma, Gastroesophageal Junction Carcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma, Squamous Cell Carcinoma of the Head and Neck, Epithelial Ovarian Carcinoma, Fallopian Tube Carcinoma, Endometrial Carcinoma, Renal Cell Carcinoma, Rectal Adenocarcinoma
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Transdiagnostic Behavior Therapy Vs TAU for Adjustment Disorder Following Traumatic Event Exposure
NCT06433271
Recruiting
Adjustment Disorder (AjD) is the most common mental health condition diagnosed in Active Duty personnel, and is diagnosed following an extreme stress event such as traumatic loss of a comrade, serious accident or injury, or other intense stress event. Despite its high prevalence, no evidence based treatment for AjD has been subjected to randomized controlled trials. This study seeks to build on the research team's pilot work across several disorders study to benefit service members and Veterans... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Ralph H. Johnson VA Health Care System, Charleston, South Carolina
Conditions: Adjustment Disorders, Mental Disorder
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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848
Recruiting
This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Carolina Urologic Research Center, Myrtle Beach, South Carolina
Conditions: Non-muscle-invasive Bladder Cancer
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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
NCT06719583
Recruiting
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Parkinson Disease
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Quatera 700 vs. Centurion
NCT06225362
Recruiting
Phacoemulsification is the most common treatment for cataract surgery in the developed countries and over the years it gained importance due to several factors: small incision, surgery performed under topical anesthesia - which reduce injection-related complications - short recovery time, low post operatory induced astigmatism, and low incidence of surgical complications, when compared to the conventional surgeries. The study evaluates 2 different phacoemulsification devices in patients undergoi... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
12/02/2024
Locations: Carolina Eyecare Physicians, LLC, Mount Pleasant, South Carolina
Conditions: Cataract
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A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo
NCT06163326
Recruiting
This study is to evaluate how safe and effective ritlecitinib is in participants with non-segmental vitiligo (NSV). Ritlecitinib is studied in patients with non-segmental vitiligo. Vitiligo is a chronic acquired depigmentation disorder characterized by well-defined pale white patches of skin. Non-segmental vitiligo is an autoimmune disorder and is the focus of this study. The study will show: * if the repigmentation (the recovery of pigmentation) achieved in study B7981040 (also called the "p... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
12/02/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Vitiligo
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