South Carolina is currently home to 1231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of the Efficacy and Safety of NST-1024 Versus Placebo in Subjects With Hypertriglyceridemia
NCT05889156
Recruiting
This is a Phase IIa,multicentre proof of concept study consisting of 2 study periods to study Treatment with NST-1024 as an adjunct to diet to reduce triglyceride (TG) levels in subjects with TG levels of ≥500 mg/dL and ≤2000 mg/dL; determined by percentage change in TG from baseline after 28 days of treatment. The two periods consist of: A 3-week screening period that includes a TG qualifying period, and A 28-days, double-blind, randomized, parallel group, placebo-controlled treatment period.... Read More
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
12/12/2023
Locations: Palmetto Clinical Reserach, Summerville, South Carolina
Conditions: High Triglycerides
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Prospective Study of Pregnancy in Women With Cystic Fibrosis
NCT04828382
Recruiting
In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
Gender:
Female
Ages:
16 years and above
Trial Updated:
12/12/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pregnancy Related, Cystic Fibrosis
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Reduction of Myopotential Interference With Smart Pass in S-ICD Patients
NCT05766943
Recruiting
This study is enrolling participants who are already implanted with a S-ICD device ( subcutaneous ICD), and are undergoing a routine outpatient clinic follow up appointment to have their S-ICD checked. The aim of the study is to see if a feature in the device can recognize muscle movement and differentiate movement from irregular heart signals. The study involves doing some simple arm exercises while collecting device data, both with this feature turn on and then with it turned off. Participants... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/11/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Subcutaneous ICD, Myopotential Interference
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Maribavir vs. Valganciclovir for CMV Prophylaxis in High-Risk Kidney Transplant Recipients
NCT06034925
Recruiting
The purpose of this study is to find out if there is a difference in how well the standard MUSC cytomegalovirus (CMV) prevention medicine works, compared to a different medicine, in preventing CMV infections in kidney transplant recipients who are at risk for this type of infection, while also assessing the tolerability of these two regimens. The two medication regimens being compared are Valganciclovir (FDA approved to prevent and treat CMV infection) vs Maribavir (FDA approved to treat CMV inf... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Transplant Complication, CMV
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A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD)
NCT05919693
Recruiting
EYE103-101 is a 2-part study assessing safety and preliminary efficacy of EYE103 in patients with diabetic macular edema (DME) given as monotherapy or neovascular macular degeneration (NVAMD) given in combination with anti-VEGF. In the first part, termed the multiple ascending dose (MAD) portion of study, the safety of EYE103 will be assessed at escalating doses. Approximately 12 participants will be entered in this part of the study. In the second part of the study, called the dose finding pa... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
12/05/2023
Locations: West Columbia, SC, West Columbia, South Carolina
Conditions: Neovascular Age-related Macular Degeneration (NVAMD), Diabetic Macular Edema (DME)
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Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies
NCT05705505
Recruiting
This study will assess the safety and efficacy of increasing doses of narazaciclib (ON 123300) in combination with the standard daily dose (2.5mg) of letrozole in patients with Recurrent Metastatic Low-grade Endometrioid Endometrial Cancer and other Gynecologic Malignancies.
Gender:
Female
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Greenville Health System, Institute for Oncology Clinical Research, Greenville, South Carolina
Conditions: Endometrioid Endometrial Cancer
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Study of ON 123300 in Patients With Advanced Cancer
NCT04739293
Recruiting
This study will investigate the safety of the drug ON 123300 at increasing doses to determine the best dose to use in future clinical trials.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Greenville Health System, Institute for Oncology Clinical Research, Greenville, South Carolina
Conditions: Solid Tumors, Adult
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Dotarem Evaluation for Myocardial Perfusion CMR
NCT03937921
Recruiting
The overall goal of this study is to investigate the signal intensity and relaxation rate characteristics of gadoterate meglumine (Dotarem, Guerbet, USA) enhanced myocardium during rest and stress perfusion cardiovascular magnetic resonance (CMR) compared to gadobutrol (Gadavist) to prove that Dotarem provides constantly high myocardial relaxation necessary for accurate quantitative perfusion evaluation. The purpose of this study is to compare two types of contrast that patients receive during... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Myocardial Perfusion Imaging, Magnetic Resonance Imaging
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Beneficial or Fostering Future Struggles (B.F.F.s)? Characterizing the Role of Friends in the Development of 13- to 17-Year-Old Adolescents
NCT05893459
Recruiting
The goal of this clinical trial is to investigate how the friendship experiences of maltreated (i.e., abused and/or neglected) and non-maltreated adolescents differentially influence their risk for adverse outcomes. The main questions it aims to answer are: How do the friendships of maltreated adolescents differ from those of non-maltreated adolescents? Which friendship experiences influence the associations between maltreatment and ability to regulate stress, as well as future mental health di... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
12/04/2023
Locations: University of South Carolina, Columbia, South Carolina
Conditions: Child Maltreatment, Interpersonal Relations
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Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161
Recruiting
This prospective study is a multi-center early feasibility study assessing the safety and performance of the Aria CV Pulmonary Hypertension System in patients with pulmonary hypertension and right heart dysfunction.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
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Physiological Changes Induced Through MEP Conditioning in People With SCI
NCT04286191
Recruiting
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a result of this type of training. After spinal cord injury, brain-to-muscle connections are often interrupted. Because these connections are important in movement control, when they are not working well, movements may be disturbed. Researchers have found that people can lear... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
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Metabolically Fit CD19 CAR T-cell Therapy With CD34 Selection in Patients With CD19+ Relapsed/Refractory NHL, CLL/SLL
NCT05702853
Recruiting
This is a single-center, nonrandomized, open-label dose-escalation study followed by dose-expansion of CD19- CD34t metabolically programmed CAR T-cell therapy in adult patients with relapsed or refractory CD19 B-cell non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
Gender:
All
Ages:
18 years and above
Trial Updated:
12/03/2023
Locations: Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina
Conditions: B-cell Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
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