South Carolina is currently home to 1173 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Charleston, Greenville, Spartanburg and Columbia. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RM1 Project 1 - tAN Naloxone
NCT05490134
Recruiting
This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute transcutaneous auricular neurostimulation (tAN) intervention are mediated through a release of endogenous opioids. Analgesic effects of four various stimulation interventions will be measured (auricular vagus, auricular trigeminal, combination, or sham) while varying the type of intravenous (IV) infusion (either naloxon... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Analgesia
Register for Updates
RM1 Project 2 - tAN fMRI
NCT05487664
Recruiting
In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone.... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/09/2024
Locations: Medical University of South Carolina Institute of Psychiatry, Charleston, South Carolina
Conditions: Auricular Stimulation
Register for Updates
Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System
NCT03831386
Recruiting
Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop discomfort and chest pain during drainage. The investigators propose to evaluate gravity drainage and suction drainage on quality of life measures and outcom... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Pleural Effusion
Register for Updates
US National OCS Heart Perfusion (OHP) Registry
NCT05915299
Recruiting
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Heart Transplant
Register for Updates
Blood Warming in Preterm Infants to Decrease Hypothermia
NCT05170633
Recruiting
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by The World Health Organization. Another acute morbidity is anemia in preterm infants due to the prematurity and frequent laboratory testing. Anemia requires correction with a packed red blood cells (PRBC... Read More
Gender:
ALL
Ages:
Between 24 weeks and 32 weeks
Trial Updated:
12/05/2024
Locations: Kayla Everhart, Columbia, South Carolina
Conditions: Preterm Birth, Blood Transfusion Complication, Hypothermia
Register for Updates
Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
ALL
Ages:
Between 1 year and 120 years
Trial Updated:
12/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
Register for Updates
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
NCT04171323
Recruiting
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
12/05/2024
Locations: Clemson University, Seneca, South Carolina
Conditions: Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
Register for Updates
Transdiagnostic Behavior Therapy Vs TAU for Adjustment Disorder Following Traumatic Event Exposure
NCT06433271
Recruiting
Adjustment Disorder (AjD) is the most common mental health condition diagnosed in Active Duty personnel, and is diagnosed following an extreme stress event such as traumatic loss of a comrade, serious accident or injury, or other intense stress event. Despite its high prevalence, no evidence based treatment for AjD has been subjected to randomized controlled trials. This study seeks to build on the research team's pilot work across several disorders study to benefit service members and Veterans... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Ralph H. Johnson VA Health Care System, Charleston, South Carolina
Conditions: Adjustment Disorders, Mental Disorder
Register for Updates
A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848
Recruiting
This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Carolina Urologic Research Center, Myrtle Beach, South Carolina
Conditions: Non-muscle-invasive Bladder Cancer
Register for Updates
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
NCT06719583
Recruiting
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Parkinson Disease
Register for Updates
NAC Vs Placebo on Opioid Use for Hysterectomy
NCT06039566
Recruiting
This study will enroll females who are ages 18 and older undergoing a laparoscopic or robotic, partial or full hysterectomy. Participants will be randomized to receive IV n-acetylcysteine or placebo during the first 60 minutes of their procedure. At various time points after the procedure patients will be asked to report their pain scores, and any pain medication taken.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Hysterectomy
Register for Updates
The Effects of High-Intensity Functional Training in Tactical Populations
NCT06582251
Recruiting
The purpose of this study is to investigate the effects of high-intensity functional training (HIFT) as compared to traditional resistance training (RT) and concurrent training consisting of RT and high-intensity interval training (HIIT) on physical performance metrics, body composition, and mental and physical readiness of tactical personnel.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
11/29/2024
Locations: University of South Carolina Sport Science Lab, Columbia, South Carolina
Conditions: Healthy
Register for Updates