Houston, TX Paid Clinical Trials

To evaluate whether Fuzuloparib plus AA-P is superior to placebo plus AA-P as first-line treatment by assessment of radiographic progression-free survival (rPFS) in mCRPC subjects unselected for deoxyribonucleic acid (DNA) damage repair deficiencies (DRD) status (Cohort 1) to evaluate whether Fuzuloparib plus AA-P is superior to placebo plus AA-P as first-line treatment by assessment of rPFS in mCRPC subjects harboring DRD (Cohort 2). Read Less

Horizon Outreach has developed the Horizon Eagle Fatherhood Program (HEFP). HEFP includes a program/services aspect, but also includes a rigorous evaluation component, featuring a randomized control trial (RCT) research design. The evaluation will determine the effect of the Horizon Eagle Fatherhood Program with fathers aged 18 and up in Houston, Texas. Specifically, the research is examining the effects of the program relative to: (1) improvement in healthy relationship and marriage skills, (2) improvement in parenting skills, (3) improvement in conflict resolution and anger management skills, and (4) improvement in financial management skills and progress toward greater economic stability. Program participants will be randomly assigned to either the intervention group or the control group. Participants assigned to the intervention group will receive the program now. Participants assigned to the control group will have an opportunity to receive the program later. All participants (intervention and control) will complete a pretest questionnaire. Intervention participants will then participate in the Horizon Eagle Fatherhood program. This is an intensive 40-hour classroom-based program taught by project staff. Both intervention and control participants will receive case management services. Following completion of the program by the intervention participants, all participants will complete a posttest questionnaire. After completion of the posttest, all participants will have an opportunity to participate in a workforce training program. Six months following posttest, all participants will complete a third questionnaire. In addition, a selected number of participants will participate in focus groups. After completing the six-month follow-up questionnaire, participants from the control group may participate in the 40 hours of classroom instruction, should they choose to do so. This RCT research design component of the Horizon Eagle Fatherhood Program began in June of the second project year. Prior to the start of the RCT, a pilot/readiness project with no control group was conducted. This was followed by a short-term pilot of the RCT. Read Less

The purpose of this study is to characterize the safety and tolerability of FWD1509 MsOH in advanced NSCLC patients and establish the maximum tolerable dose (MTD), recommended phase 2 dose (RP2D) in advanced NSCLC patients. Read Less

Eligible participants will complete the COMPASS 31 (year), modified COMPASS 31(one month) and the NSI (one month) questionnaires at baseline and complete the modified COMPASS 31 and the NSI after usual care of treatment. The investigators will Compare results for the COMPASS 31(year) to the modified COMPASS 31(month) at baseline. Compare modified COMPASS 31(month) to the NSI at baseline and post intervention. Read Less

The primary efficacy endpoint for this study is the proportion of subjects with complete closure of Target Ulcer during the 20-week Treatment Phase, which is assessed by the blinded independent evaluator. Read Less

A first-in-human study using BIO-106 as a single agent and in combination with pembrolizumab in advanced cancers. Read Less

This is a phase 2, multi-center, randomized, placebo-controlled, double-blind, parallel-group, dose-ranging study, conducted in subjects with moderate-to-severe atopic dermatitis. Read Less

The purpose of this study is to assess the change in 24-hour ambulatory blood pressure monitoring (ABPM) between baseline (Day 0) and Day 120 following 4 months of testosterone therapy with Natesto. Read Less

This is a single-center, randomized, blinded, controlled trial assessing the effects on the skin microbiome in patients with eczema of amending a standard-of-care (SOC), over-the-counter (OTC) topical colloidal oatmeal formulation with a modified plant oil ("Activated Oil", AO) Read Less

The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children. Read Less

The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid organ transplant (SOT) after failure of rituximab and rituximab plus chemotherapy or (2) allogeneic hematopoietic cell transplant (HCT) after failure of rituximab. Read Less

This study investigates if a new type of test called Droplet-BC screening test can classify breast cancer patients from non-cancer volunteers by circulating small-noncoding RNA in the blood with a statistical validity. This study also investigates if this test can classify the subgroup of breast cancer patients with a variety of conditions. Information from this study may provide a new method of breast cancer screening/diagnosis Read Less