The state of Texas currently has 45 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Houston, Dallas, San Antonio and Austin.
Wellness App for Sleep Disturbance in Hematological Cancer Patients
Recruiting
In a randomized controlled trial (RCT), the investigators will recruit participants to an 8-week "app-based wellness" intervention, followed by a 12-week follow-up period. The investigators will recruit a total of 276 self-declared Chronic Hematological Cancer (CHC) patients who (representative of age, race/ethnicity, and gender) will be on stable CHC pharmacologic therapy (if any), self-identify as sleep disturbed (>5 on Pittsburgh Sleep Quality Index), do not have a sleep disorder diagnosis, d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2024
Locations: Mays Cancer Center at The University of Texas Health Science Center at San Antonio, San Antonio, Texas
Conditions: Cancer, Sleep Disturbance, Anxiety, Depression, Inflammation, Fatigue
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
Recruiting
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to antidepressant treatment response (remission, recurrence, relapse and individual outcomes in depressive disorders) and resilience. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participa... Read More
Gender:
All
Ages:
10 years and above
Trial Updated:
03/21/2024
Locations: Afrida Khurshid, Dallas, Texas
Conditions: Depression, Treatment Resistant Depression, Mood Disorders, Bipolar Disorder, Mental Disorders, Bipolar and Related Disorders
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: UT Health Science Center at Houston (UTHSC-H), Houston, Texas
Conditions: Treatment Resistant Depression
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Recruiting
The objective of this study is to collect data to finalize the development of MEB-001 software as a medical device. The data collected in this study will be used to develop MEB-001 machine learning algorithms by training the algorithms to match the patient's demographic and clinical information, and the objective physiological signals (i.e., electroencephalogram (EEG) and electrocardiogram (ECG)) recorded during PSG with the diagnosis of cMDE performed through the MINI neuropsychiatric evaluatio... Read More
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
03/20/2024
Locations: Comprehensive Sleep Medicine Associates, Austin, Texas +2 locations
Conditions: Depressive Episode, Depression, Depressive Disorder, Depressive Disorder, Major, Depression Mild
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: The University of Texas at Austin - Dell Medical School, Austin, Texas +3 locations
Conditions: Treatment Resistant Depression
BPL-003 Efficacy and Safety in Treatment Resistant Depression
Recruiting
This is a Phase 2 study randomized, quadruple masked, multi-center study designed to investigate the efficacy and safety of a single dose of BPL-003 combined with psychological support in patients with treatment resistant depression (TRD).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2024
Locations: AIM Trials, Plano, Texas
Conditions: Treatment Resistant Depression
Telehealth Behavioral Activation for Teens
Recruiting
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to increase an individual's engagement in valued and enjoyable activities (e.g., socializing with family and friends, exercising, participating in a hobby) in order to improve depressive symptoms. Research has shown that behavioral activation is an effective intervention for depr... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
03/18/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
Exploring the Effects of Corticosteroids on the Human Hippocampus
Recruiting
Chronic corticosteroid (CS) exposure is associated with changes in memory and the hippocampus in both humans and in animal models. The hippocampus has a high concentration of glucocorticoid receptors (GCRs), and the pre-clinical literature demonstrates shortening of apical dendrites in the CA3 region of the hippocampus and decreased neurogenesis in the dentate gyrus (DG) following CS administration. In humans, both stress and CS exposure are associated with a decline in declarative memory perfor... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
03/14/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Hydrocortisone, Depression, Healthy Volunteers
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: UT Health Austin, Mulva Clinic for the Neurosciences, Austin, Texas +7 locations
Conditions: Treatment Resistant Depression
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
03/04/2024
Locations: BioBehavioral Research of Austin /ID# 227076, Austin, Texas +7 locations
Conditions: Depression, Bipolar I Disorder
Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents
Recruiting
Despite increasing suicide rates in adolescents, there remains a paucity of approaches to use to prevent re-attempts. Any hope for breaking the code to prevent youth suicide lies in understanding biological factors that play a role. Evidence suggests that inflammation and immune system dysfunction may be linked to suicide. The investigators will develop immune profiles for adolescents with suicidal behavior and those at risk in order to develop tools that can be implemented for prevention effort... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
03/04/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Suicide and Depression
Does Adding a Tailored Cognitive Behavioral Therapy (CBT) Mobile Skills App Mediate Rates of Depression
Recruiting
Depression is a common psychological disorder seen in 18.5% of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans. Improving the rate of depression recovery and remission is vital to enhance OEF/OIF/OND Veteran's ability to improve work and home adjustment and overall quality of life. OEF/OIF/OND Veterans have reported many barriers to following through with Cognitive therapy skills practice assignments, a key component of CBT therapy, the lead... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
02/22/2024
Locations: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas
Conditions: Depression