Indiana is currently home to 1204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Molecular Mechanisms Associated With Breast Implant Complications
NCT05736354
Recruiting
Bacterial biofilms cause implant failures, chronic inflammation, and immune polarization. The study investigates the possible role of bacterial biofilm as a factor in the etiology of Breast Implant Illness. Three patient cohorts will be studied (A) Subjects with breast implant with BII manifestations (B) Subjects with breast implants without BII manifestations (C) Subjects without breast implants who underwent breast surgery procedure. Blood, surgically discarded tissue, implants, and associated... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: IU Health North Hospital, Carmel, Indiana
Conditions: Breast Implant; Complications, Infection or Inflammation
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ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies
NCT05653271
Recruiting
ACE1831 is an off-the-shelf, allogeneic gamma delta T (gdT) cell therapy derived from healthy donors, that is under investigation for the treatment of CD20-expressing B-cell malignancies. The ACE1831-001 study is an open-label, Phase I, first-in-human (FIH) study that aims to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and efficacy of ACE1831 in patients with CD20-expressing Non-Hodgkin lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana
Conditions: B-cell Lymphoma, Non Hodgkin Lymphoma, DLBCL, Primary Mediastinal Large B Cell Lymphoma, Marginal Zone Lymphoma, Follicular Lymphoma
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Dissemination and Implementation of Improving Pediatric Obesity Practice Using Prompts
NCT05627011
Recruiting
The purpose of this study is to evaluate the dissemination and implementation of electronic health record-based clinical decision support tools for the management of pediatric overweight and obesity in primary care.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/27/2024
Locations: Eskenazi Health, Indianapolis, Indiana
Conditions: Obesity, Childhood
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Indiana University, Indianapolis, Indiana
Conditions: Huntington's Disease
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Mediterranean Diet Versus Western Diet on Fatigue in Autoimmune Hepatitis Patients
NCT06250309
Recruiting
This is a single-center, proof-of-concept pilot study which uses a cross-over design to compare two dietary interventions/treatments: Western Diet (WD) vs Mediterranean (MD) and impact on quality-of-life parameters in AIH. Participants will receive both treatments through two phases and will be divided into two groups.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/19/2024
Locations: IU Health University Hosptial, Indianapolis, Indiana
Conditions: Autoimmune Hepatitis
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A Study to Investigate Leramistat in Patients With IPF
NCT05951296
Recruiting
To compare the effect of daily oral dosing of leramistat over 12 weeks with placebo in participants aged 40 years or older with idiopathic pulmonary fibrosis (IPF).
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/16/2024
Locations: IU Health Ball Memorial Physicians Pulmonary and Critical Care Medicine, Muncie, Indiana
Conditions: Idiopathic Pulmonary Fibrosis
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ELUCIDATE FFRct Study
NCT06018194
Recruiting
The goal of this study is to evaluate the diagnostic accuracy of a novel plaque-based coronary CT angiography (CCTA) fractional flow reserve (FFRct) software device for the estimation of invasive fractional flow reserve (FFR). Researchers will compare the Elucid plaque-based FFRct analysis to invasively measured FFR in patients who have previously undergone CCTA and invasively assessed FFR.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: Parkview Health, Fort Wayne, Indiana
Conditions: Coronary Artery Disease
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cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881
Recruiting
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mort... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/15/2024
Locations: Baptist Floyd, New Albany, Indiana
Conditions: Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Stomach Cancer, Head and Neck Cancer, Hepatobiliary Cancer, Leukemia, Lung Cancer, Lymphoma, Multiple Myeloma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Renal Cancer, Sarcoma, Thyroid Cancer
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The Impact of Beef on Muscle Fatigue in Older Adults
NCT05860088
Recruiting
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are: AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet. AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue. Participants will be randomized to consume either a beef-based diet or... Read More
Gender:
ALL
Ages:
Between 60 years and 85 years
Trial Updated:
02/07/2024
Locations: Indiana University Bloomington, Bloomington, Indiana
Conditions: Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
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Pediatric Cardiomyopathy Mutation Analysis
NCT02432092
Recruiting
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder. This will provide the basis for future genetic counseling as well as contribute to elucidating the biology of normal and abnormal cardiac function.
Gender:
ALL
Ages:
All
Trial Updated:
02/05/2024
Locations: IU School of Medicine, Indianapolis, Indiana
Conditions: Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Left Ventricular Non-compaction Cardiomyopathy
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Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
NCT02432079
Recruiting
The goal of this study is to obtain specimens and data from individuals and their families with heterotaxy and related congenital heart defects in order to clarify the molecular genetics of this disorder. The knowledge gained from the analysis of this information will provide the basis for future genetic counseling as well as contribute to knowledge about the biology of normal and abnormal development of left-right anatomic asymmetry.
Gender:
ALL
Ages:
All
Trial Updated:
02/05/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Heterotaxy Syndrome, Congenital Heart Defects
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Prevalence of Hemorrhagic Myocardial Infarction in the United States
NCT06162039
Recruiting
Registry analysis for prevalence of hemorrhagic myocardial infarction in the United States
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: Krannert Cardiovascular Research Center, Indianapolis, Indiana
Conditions: Acute Myocardial Infarction
Register for Updates