Ohio is currently home to 3199 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Endoscopic Ultrasound-guided Radiofrequency Ablation of Pancreatic Cysts (ERASE)
NCT05916846
Recruiting
A single-center study to determine the safety and efficacy of EUS-guided radiofrequency ablation (RFA) of pancreatic cystic neoplasms (PCNs). Patients will be recruited sequentially to undergo RFA followed by standard surveillance. The study will recruit patients with pancreatic cystic lesions (PCLs) who are at high risk for surgical resection. Patients enrolled in the study will be followed up for 3-years after EUS-guided RFA.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/14/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Pancreatic Cyst, Radiofrequency Ablation
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A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumors
NCT05268666
Recruiting
The purpose of this study is to determine the maximum-tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of JBI-802 in patients with Advanced Solid Tumors.The efficacy of the RP2D will be evaluated in phase 2 in patients with solid tumors of neuroendocrine differentiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2023
Locations: The Christ Hospital, Cincinnati, Ohio
Conditions: Locally Advanced Solid Tumor, Metastatic Solid Tumor
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Curvafix® Intramedullary System for Fixation of Pelvic and Acetabular Fractures, A Post Market Evaluation
NCT05606042
Recruiting
Prospective, single arm, post-market evaluation to evaluate the use and performance of the IM Implant in a post market setting.
Gender:
ALL
Ages:
All
Trial Updated:
06/09/2023
Locations: Mount Carmel Research Institute, Columbus, Ohio
Conditions: Pelvic Ring Fracture, Acetabular Fracture, Pelvic Fracture, Pelvic Fracture Acetabulum
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Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
NCT05291884
Recruiting
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of the Impella BTR™ in supporting patients to recovery or their next therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/07/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heart Failure, Acute Decompensated Heart Failure
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Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
NCT05622461
Recruiting
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial. To achieve the second goal, we will employ a between-groups randomized treatment design with repeated measures at baseline, one-month post-randomization, and at a six-month follow-up. The two conditions will be: a) usual medical care plus access to internet resources regarding pediatric brain injury (Internet Resources Compari... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/31/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic, Brain Edema, Intracranial Edema
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A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors
NCT03797391
Recruiting
First-in-human, Phase I/II, Multicenter, Open-Label Study of EMB-01 in Patients with Advanced/Metastatic Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: Gabrail Cancer Center Research, Canton, Ohio
Conditions: Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
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Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors
NCT05856981
Recruiting
This first-in-human, open-label, multicenter, multi-arm dose-escalation study is designed to evaluate the safety, PK, and PD of ADU-1805, an anti- SIRPα monoclonal antibody, as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/26/2023
Locations: Gabrail Cancer & Research Center, Canton, Ohio
Conditions: Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer
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International CIPN Assessment and Validation Study
NCT04633655
Recruiting
This is an observational study of chemotherapy-induced peripheral neurotoxicity (CIPN) patients to be investigated prospectively in order to assess responsiveness of a set of outcome measures in an international multi-center study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Cancer Center/Wexner Medical Center - Ohio State Medical Oncology Division, Columbus, Ohio
Conditions: Chemotherapy-induced Peripheral Neuropathy, Quality of Life
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Biology of Juvenile Myoclonic Epilepsy
NCT03400371
Recruiting
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve pa... Read More
Gender:
ALL
Ages:
Between 10 years and 40 years
Trial Updated:
05/24/2023
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Juvenile Myoclonic Epilepsy
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Diagnostic POCUS of Patellar Tendinopathy in Female Athletes
NCT05880277
Recruiting
Purpose: The purpose of this study is to determine the clinical effectiveness of point-of-care diagnostic ultrasound in the assessment of patellar tendon pathologies
Gender:
FEMALE
Ages:
Between 18 years and 25 years
Trial Updated:
05/18/2023
Locations: Youngstown State University, Youngstown, Ohio
Conditions: Patellofemoral Disorder
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Increased Home-based Physical Therapy Adherence Using BAND Connect's VirtuaCare™ Platform
NCT05876208
Recruiting
This study aims to enhance at-home therapy by introducing a new device called the BAND Connect's VirtuaCare™ platform. The study aims to determine whether patients can improve their adherence to at-home exercises using this device. Currently, research indicates that only 35% of patients undergoing physical therapy treatment fully comply with their prescribed plans of care, often neglecting their at-home exercises. To address this issue, a set of smart exercise tools called VirtuaCare™ has been d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Shoulder Injuries
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ROSE-Longitudinal Assessment With Neuroimaging
NCT05089331
Recruiting
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Intracerebral Hemorrhage
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