Rhode Island is currently home to 499 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Solid Tumor, Adult
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A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
NCT05543616
Recruiting
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. * Substudy A design: Phase 1 includes participa... Read More
Gender:
ALL
Ages:
Between 6 months and 11 years
Trial Updated:
05/13/2024
Locations: Velocity Clinical Research, Providence, East Greenwich, Rhode Island
Conditions: SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
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Mindfulness, Optimism, and Resilience for Perinatal Health and Equity Study
NCT05840900
Recruiting
Dispositional optimism (the general assumption that more good things than bad will occur across various life domains) has been tied to improved somatic and mental health outcomes. Dispositional optimism is malleable, although prior interventions have been time and resource intensive and thus are not well-tailored to the peripartum period. The purpose of this pilot study is to evaluate the feasibility and acceptability of a pregnancy-oriented mindfulness phone application (Expectful) versus stand... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: Obstetrics and Gynecology Care Center, Providence, Rhode Island
Conditions: Postpartum Psychiatric Disorders
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Using Microbiome to Predict Durvalumab Toxicity in Post- Concurrent Chemoradiation Therapy (CCRT) NSCLC Patients
NCT04680377
Recruiting
This phase IV study is hoping to determine if examining the microbiome in non-small cell lung cancer participants who will receive durvalumab can predict treatment toxicity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Rhode Island Hospital, Brown University, Providence, Rhode Island
Conditions: NSCLC, Stage III, Locally Advanced Lung Carcinoma
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RCT of Pain Perception With Fast and Slow Tenaculum Application
NCT05458037
Recruiting
This project will be a randomized controlled trial (RCT) measuring pain perception with two different tenaculum placement techniques on the uterine cervix. A tenaculum is an instrument used to hold the cervix (the opening to the uterus or womb) in place. The trial will measure pain perception with a Visual Analog Scale (VAS) from 0 to 100 mm for two different tenaculum placement techniques, fast and slow closure on the uterine cervix. The main objective of this study is to determine if there is... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Women and Infants Hospital, Providence, Rhode Island
Conditions: Pain, Acute, Pain, Procedural
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Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
NCT05230173
Recruiting
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Gastroenterology Associates, Providence, Rhode Island
Conditions: Ulcerative Colitis, Crohn Disease
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A Multi-Center Post-Market Data Collection Protocol to Evaluate the Performance of Orthofix Spine Devices
NCT05082090
Recruiting
This protocol is designed to study Orthofix regulatory approved and commercially available spine devices to generate Real World Evidence (RWE) of device safety and performance in the treatment of patients with spine injuries and/or disorders following the local medical standard of care. The clinical data generated from this study will support compliance to global regulatory requirements including but not limited to the European Medical Device Regulation (EU MDR) for the applicable devices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: University Orthopedics, East Providence, Rhode Island
Conditions: Spinal Disorders/Injuries
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Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
NCT00736749
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Gender:
ALL
Ages:
All
Trial Updated:
04/10/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
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The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
NCT05723445
Recruiting
This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults with cystic fibrosis-related diabetes (CFRD). We will use continuous glucose monitors (CGM) to assess the LGL diet both in a controlled setting (via a meal delivery company) and in free-living conditions.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/09/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis With Intestinal Manifestations
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Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews
NCT06354465
Recruiting
This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a correctional setting. The research aims to understand if XR-B can be a feasible and effective alternative to the standard daily treatment and to identify which groups within the prison population may benefit the most from this treatment. In-depth interviews are conducte... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: Rhode Island Department of Corrections, Cranston, Rhode Island
Conditions: Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
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Control Systems Engineering for Weight Loss Maintenance
NCT06244888
Recruiting
This project capitalizes on principles of control systems engineering to build a dynamical model that predicts weight change during weight loss maintenance using behavioral, psychosocial, and environmental indicators evaluated in a system identification experiment. A 6-month behavioral obesity treatment will be administered to produce weight loss. Participants losing at least 3% of initial body weight will be followed for an additional 12 months via daily smartphone surveys that incorporates pas... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/01/2024
Locations: Miriam Hospital Weight Control and Diabetes Resarch Center, Providence, Rhode Island
Conditions: Overweight and Obesity
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Joyuus - A Web-based Tool for Postpartum Care Self-care for Underserved Women
NCT05876559
Recruiting
The goal of this RCT is to evaluate the effectiveness of Joyuus on improving maternal functioning with postpartum moms. The main questions it aims to answer are: * The primary hypothesis is that participants of the Joyuus program will demonstrate improved functional status compared to the control arm participants at 3-month follow-up. * The secondary hypotheses are that participants using the Joyuus tool will demonstrate improvement in depression, anxiety, resilience, social support, and knowle... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
03/22/2024
Locations: Lisa Marceau, Westerly, Rhode Island
Conditions: Maternal Health
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