Alabama is currently home to 1295 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation
NCT04950894
Recruiting
Multi-center, open-label, prospective, randomized clinical trial of the aura6000(R) System for the reduction of apnea and hypopneas in adult patients with moderate to severe obstructive sleep apnea who have failed or are unwilling to use positive airway pressure treatment.
Gender:
All
Ages:
22 years and above
Trial Updated:
02/02/2023
Locations: University of Alabama At Birmingham, Birmingham, Alabama
Conditions: Obstructive Sleep Apnea, OSA, Apnea, Apnea, Obstructive, Apnea, Obstructive Sleep, Apnea+Hypopnea, Hypopnea, Sleep
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ACT NOW Longitudinal Study: Outcomes of Babies With Opioid Exposure Study
NCT04149509
Recruiting
The objective of this longitudinal cohort study is to quantify the effects of antenatal opioid exposure on the trajectory of brain development over the first 2 years of life, examine associations with developmental and neurobehavioral outcomes, and explore how specific factors (differing antenatal and postnatal exposures, severity of neonatal opioid withdrawal, maternal stress/depression/parenting) modify these effects
Gender:
All
Ages:
1 month and below
Trial Updated:
01/31/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Neonatal Opioid Withdrawal Syndrome
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CorMatrix Cor TRICUSPID ECM Valve Replacement Study
NCT02397668
Recruiting
The Pivotal Study of the Cor TRICUSPID ECM Valve (or Cor PEDIATRIC Tricuspid ECM Valve). This study follows the EFS and is now to determine the safety and efficacy of the Cormatrix Cor TRICUSPID Valve for any patients requiring surgical replacement of the tricuspid valve.
Gender:
All
Ages:
Between 1 year and 70 years
Trial Updated:
01/25/2023
Locations: Springhill Memorial Hospital, Mobile, Alabama
Conditions: Tricuspid Valve Disease
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Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Birmingham, Alabama
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
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Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)
NCT04502316
Recruiting
The purpose of this registry is to develop valid scientific evidence of the safety and benefit of Barostim Therapy in the commercial setting in patients with heart failure with reduced ejection fraction (HFrEF) that were recently implanted with the Barostim System.
Gender:
All
Ages:
All
Trial Updated:
01/21/2023
Locations: Grandview Medical Center, Birmingham, Alabama
Conditions: Heart Failure
Register for Updates
Safety of Co-Administered CHI-554 and Alcohol
NCT05317507
Recruiting
This is a Phase 1, randomized, double-blind study to assess the safety, tolerability, and effects of CHI-554 when co-administered with alcohol.
Gender:
All
Ages:
Between 21 years and 65 years
Trial Updated:
01/12/2023
Locations: Auburn University, Auburn, Alabama
Conditions: Healthy Adults
Register for Updates
Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
All
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: University of Alabama, Birmingham, Alabama
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
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Smoking Reduction In Gravid Substance Use Disorders
NCT04132232
Recruiting
The aim of this study is to encourage smoking cessation in women with substance use disorders by providing knowledge of expired carbon monoxide. We hypothesize that women who are provided knowledge of their expired carbon monoxide and the associated percent fetal carboxyhemoglobin will have a greater success at quitting smoking during pregnancy than women who are not provided this information. A secondary aim of the study is to correlate expired carbon monoxide throughout pregnancy with infant... Read More
Gender:
Female
Ages:
Between 16 years and 45 years
Trial Updated:
12/19/2022
Locations: University of Alabama, Birmingham, Alabama
Conditions: Tobacco Smoking in Mother Complicating Pregnancy, Tobacco Use Disorder, Tobacco Smoking
Register for Updates
International Weight Control Registry
NCT04907396
Recruiting
The IWCR is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. The investigators seek to gather information on a wide range of weight management experiences, ranging from weight loss and weight loss maintenance to weight gain and inability to lose weight.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2022
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Weight Loss, Overweight, Obesity
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A Study to Evaluate EDP-235 in Non-hospitalized Adults With COVID-19
NCT05616728
Recruiting
Study of EDP-235 in Non-hospitalized Adults with Mild or Moderate COVID-19.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
12/06/2022
Locations: Cahaba Research Inc. - Birmingham, Birmingham, Alabama
Conditions: COVID-19
Register for Updates
MEASuRE: Metreleptin Effectiveness And Safety Registry
NCT02325674
Recruiting
The study is a post-authorization, prospective, voluntary registry of patients treated with commercial metreleptin including, but not limited to, patients in the US and EEA.
Gender:
All
Ages:
All
Trial Updated:
11/23/2022
Locations: University Alabama at Birmingham, Birmingham, Alabama
Conditions: Generalised Lipodystrophy, Partial Lipodystrophy
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Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
NCT03476980
Recruiting
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC. This prospective multi-national randomized controlled trial (RCT) is a two-arm parallel non-inferiority design of two alternative approaches of treatment.
Gender:
All
Ages:
Between 22 months and 42 months
Trial Updated:
11/22/2022
Locations: University of Alabama, Birmingham, Alabama
Conditions: Neurodevelopmental Abnormality
Register for Updates