Alabama is currently home to 1237 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner (MOBI-1)
NCT04893837
Recruiting
MOBI-1 is a multicenter clinical trial that will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas.
Gender:
ALL
Ages:
15 years and above
Trial Updated:
07/03/2024
Locations: UAB Hospital, Birmingham, Alabama
Conditions: Brain Injuries, Traumatic
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Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
NCT02201992
Recruiting
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-sma... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2024
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Conditions: ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
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VIGOR: Virtual Genome Center for Infant Health
NCT05205356
Recruiting
This study will provide rigorous evaluation of implementing a virtual genome center into community clinical settings without highly specialized resources, thereby offering generalizable insights as to how best to implement genomic medicine at scale and for other age groups. This intervention has great potential to address disparities in genomic medicine among low-income and underrepresented minority (URM) populations and will enhance capacity for providers and health systems to utilize highly sp... Read More
Gender:
ALL
Ages:
Between 0 days and 99 years
Trial Updated:
06/21/2024
Locations: USA Children's and Women's Hospital, Mobile, Alabama
Conditions: Genetics Disease, Genetics/Birth Defects, Genetic Predisposition to Disease
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Impact of Astaxanthin on Cognition in Recreationally Active Females
NCT06460181
Recruiting
The purpose of this study is to examine the protentional that the antioxidant Astaxanthin has on mitigating cognitive decline following mental fatigue.
Gender:
FEMALE
Ages:
Between 18 years and 39 years
Trial Updated:
06/10/2024
Locations: University of North Alabama, Florence, Alabama
Conditions: Mental Fatigue
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Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults
NCT04396002
Recruiting
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. More... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/06/2024
Locations: University of Alabama Birmingham, Birmingham, Alabama
Conditions: Primary Open Angle Glaucoma
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Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Children's of Alabama, Birmingham, Alabama
Conditions: Bronchiolitis Acute Viral
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The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
NCT04334135
Recruiting
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen... Read More
Gender:
ALL
Ages:
Between 19 years and 75 years
Trial Updated:
05/28/2024
Locations: Kinesiology Building, Auburn, Alabama
Conditions: Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
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Minds and Mentors Program- R33
NCT05363371
Recruiting
The proposed research effort will: The purpose of this study is as follows: 1. Test the effectiveness of the Minds and Mentors Program in a group treatment trial in which individuals using medications for opioid use disorder (MOUD) will be randomized in blocks of five to receive either the Minds and Mentors Program (n=120) or Twelve Step Facilitation (n=120). 2. Determine whether the MiMP: a) improves adherence to MOUD b) reduces the rate of relapse and cravings c) decreases self-reported anxi... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/26/2024
Locations: Birmingham Veteran Affairs Medical Center, Birmingham, Alabama
Conditions: Opioid Use Disorder, Substance Use Disorders, Medication Assisted Treatment
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Multisite Implementation of COMPRENDO
NCT06055296
Recruiting
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting implementation. This study will test the impact of COMPRENDO, a peer-navigation intervention, vs. usual care on accrual to childhood cancer therapeutic clinical trials and parental informed consent out... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Children's of Alabama/University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Pediatric Cancer
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ConsideRAte Study - Splenic Stimulation for RA
NCT05003310
Recruiting
This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories. The study will consist of 4 study periods, including a Randomized Control Trial period (Period 1), an Open Label period (Period 2), a Treat-to-target period (Period 3), and a Long-term Follow-up period (Period 4). Participants eligible for implant will have active r... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
05/20/2024
Locations: Pinnacle Research Group, LLC, Anniston, Alabama
Conditions: Rheumatoid Arthritis
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Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
NCT05161169
Recruiting
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks. The study will enroll a diverse cohort of 500 healthy infants and their parents from Boston, MA; New York City, NY; and Birmingham, AL. A small blood sample will be collected from each infant, and whole genome sequencing will be performed in 1/2 of the cohort following a randomized controlled trial design. 3 months later, the randomization status and... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
05/14/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Genetic Predisposition to Disease, Hereditary Diseases
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A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
NCT05543616
Recruiting
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. * Substudy A design: Phase 1 includes participa... Read More
Gender:
ALL
Ages:
Between 6 months and 11 years
Trial Updated:
05/13/2024
Locations: UAB Child Health Research Unit (CHRU), Birmingham, Alabama
Conditions: SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
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