Alabama is currently home to 1282 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
KRT-232 and TKI Study in Chronic Myeloid Leukemia
NCT04835584
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or intolerant to a Tyrosine Kinase Inhibitor (TKI). This study is a global, open label Phase 1b/2 to determine the efficacy and safety of KRT-232 in patients with chronic phase CML (CML-CP) and accelerated phase (CML-AP) who have failed TKI treatments.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2022
Locations: University of Alabama Birmingham, Birmingham, Alabama
Conditions: Chronic Myeloid Leukemia
Register for Updates
Proof of Principle Study to Evaluate the Safety, PK, Viral Shedding and Efficacy of Pentarlandir™ UPPTA for Patients With Early COVID-19
NCT04911777
Recruiting
This is a clinical trial to evaluate the safety, PK, viral shedding and clinical effects of Pentarlandir™ UPPTA in patients with early COVID-19. Approximately 90 ambulatory subjects with mildly symptomatic early COVID-19, who have been diagnosed with COVID-19 within the prior 4 days will be enrolled.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
12/16/2021
Locations: Cullman Clinical Trials, Cullman, Alabama
Conditions: Coronavirus Disease 2019
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Sample Collection Study for the CellMax Life Circulating Tumor Cell and Circulating Tumor DNA Platforms for the Early Detection of Colorectal Cancer and Adenomas
NCT05127096
Recruiting
The purpose of this study is to collect clinical specimens from subjects with a diagnosis of colorectal cancer/advanced adenoma or undergoing a screening colonoscopy and meeting study eligibility criteria.
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
11/09/2021
Locations: CellMax Site A, Huntsville, Alabama
Conditions: Colorectal Cancer Screening
Register for Updates
The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL
NCT03509961
Recruiting
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regime... Read More
Gender:
All
Ages:
Between 1 year and 25 years
Trial Updated:
08/20/2021
Locations: Children's of Alabama/University of Alabama in Birmingham(UAB), Birmingham, Alabama
Conditions: B-cell Acute Lymphoblastic Leukemia
Register for Updates
Prospective US Radiofrequency SUI Trial
NCT04720352
Recruiting
PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Coastal Clinical Research, Mobile, Alabama
Conditions: Urinary Incontinence, Stress
Register for Updates
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
NCT04945525
Recruiting
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit. This tool is completed by the patient, outside of the office, using an internet enabled device and follows a compliance driven protocol developed by analyzing case law against physicians in mis-prescribing opioid cases. Results, in the form of a date and time stamped legal report, are instantly... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/25/2021
Locations: Sure Med Compliance, Mobile, Alabama
Conditions: Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
Register for Updates
Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal Disorder
NCT04948151
Recruiting
This study is looking to minimize side effects, while maintaining and potentially improving the therapeutic benefit to patients suffering from Female Sexual Arousal Disorder by providing a topical preparation of Sildenafil locally to the vulvar-vaginal tissue.
Gender:
Female
Ages:
21 years and above
Trial Updated:
06/24/2021
Locations: Coastal Clinical Research, Mobile, Alabama
Conditions: Female Sexual Arousal Disorder
Register for Updates
Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
NCT04445285
Recruiting
This Phase 2 Randomized Placebo Controlled Trial will determine if administering nebulized Dornase Alpha (rhDNase) to COVID-19 patients with respiratory failure is safe and will reduce 28-day mortality.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2021
Locations: University of South Alabama, Mobile, Alabama
Conditions: Covid19
Register for Updates
Juice Plus Supplement Clinical Trial
NCT04656860
Recruiting
The study is designed to determine whether encapsulated fruit and vegetable juice concentrates can improve biological indicators of cognitive and multiple dimensions of memory and learning.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
04/05/2021
Locations: University of Alabama, North East Medical Building, Tuscaloosa, Alabama
Conditions: Cognitive Impairment, Alzheimer Disease, Early Onset, Mild Cognitive Impairment
Register for Updates
The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis
NCT04784273
Recruiting
The purpose of this study is to determine the clinical efficacy of a novel sustained dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/03/2021
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Ankle Arthritis, Foot Arthritis
Register for Updates