Alabama is currently home to 1237 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients with Sickle Cell Disease
NCT05861453
Recruiting
To assess the pharmacokinetics, pharmacodynamics and safety of Epeleuton capsules in adult SCD patients who are aged ≥18 years.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: University of Alabama at Birmingham (UAB), Birmingham, Alabama
Conditions: Sickle Cell Disease
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Study in Parkinson Disease of Exercise
NCT04284436
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/12/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Parkinson Disease
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Mindfulness-Based Diabetes Education for Adults With Elevated Diabetes Distress
NCT05195138
Recruiting
Diabetes distress is common affecting over one-third of people with type 2 diabetes, negatively impacting self-management and outcomes, and disproportionately affecting low-income individuals. The proposed project will conduct a pilot randomized controlled trial comparing Mindfulness-Based Diabetes Education to standard Diabetes Self-Management Education in adults with type 2 diabetes and elevated diabetes distress who receive care within safety-net healthcare systems in order to assess feasibil... Read More
Gender:
ALL
Ages:
Between 19 years and 70 years
Trial Updated:
11/11/2024
Locations: Cooper Green Mercy Health Systems, Birmingham, Alabama
Conditions: Type 2 Diabetes
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A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old
NCT02616302
Recruiting
Gastroesophageal reflux disease (GERD) is caused by food or acid coming up from the stomach into the esophagus, repeatedly. The esophagus is the tube that carries food and liquids from the mouth to the stomach. The body uses stomach acid to break down food, but when acid rises up into the esophagus it can hurt or damage it. People with GERD often feel food coming back up into the throat and mouth and have a burning feeling in their stomach, chest, or throat, called heartburn. Other symptoms of... Read More
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
11/11/2024
Locations: University of South Alabama, Mobile, Alabama
Conditions: Gastroesophageal Reflux Disease (GERD)
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Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
NCT05853783
Recruiting
The purpose of this study is to validate the ability of the STRATICYTE™ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective cohort of patients who received biopsies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Mouth Diseases
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Vascular Effects of Acute Sodium (VEAS) Study
NCT04244604
Recruiting
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI K01HL147998). About nine out of ten Americans overconsume dietary salt. Compared to other racial groups, Black individuals are more prone to salt-sensitive hypertension and negative cardiovascular conditions associated with high salt intake. However, there is a critical need t... Read More
Gender:
ALL
Ages:
Between 19 years and 75 years
Trial Updated:
11/04/2024
Locations: Auburn University, Auburn, Alabama
Conditions: Sodium Excess, Racial Disparities, Blood Pressure, Cardiovascular Risk Factor
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Vaginal Photobiomodulation for Chronic Pelvic Pain
NCT06673108
Recruiting
The goal of this clinical study is to determine if 8 treatments with photobiomodulation using near-infrared laser energy can help reduce chronic pelvic pain in women. Additionally, researchers want to determine if treatment with this type of energy can also alleviate pain with activities such as standing, sitting, urinating, having bowel movements and intercourse.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Obgyn South, Birmingham, Alabama
Conditions: Chronic Pelvic Pain, Chronic Pelvic Pain Syndrome (CPPS)
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Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
NCT03807973
Recruiting
This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called \[Zr-89\]oxine to track the location of white blood cells (also called leukocytes) in the body. PET/MRI will be used to visualize labeled white blood cells and determine if they enter the central nervous system in conditions associated with brain inflammation (also called neuroinflammation). By better understanding the role of neuroinflammation in fibromyalg... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2024
Locations: UAB, Birmingham, Alabama
Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
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Live Attenuated Influenza Vaccine As a Nasal Model for Influenza Infection
NCT04164212
Recruiting
The purpose of this study is to develop a nasal model for influenza infection using the live attenuated influenza vaccine (LAIV). The investigators will administer LAIV to healthy adult volunteers in order to simulate influenza infection, and obtain nasal specimens to measure influenza virus and inflammatory/immune responses. In a subset of participants, cystic fibrosis transmembrane conductance regulator (CFTR) function will also be evaluated via measurement of nasal potential difference (NPD)
Gender:
ALL
Ages:
Between 18 years and 49 years
Trial Updated:
10/30/2024
Locations: UAB Lung Health Center, Birmingham, Alabama
Conditions: Influenza
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Improving Access and Affordability of Adult Hearing Healthcare
NCT04671381
Recruiting
This project will address quality of care issues associated with hearing loss in adults who have mild-to-moderate hearing loss and who have no access to hearing healthcare. Through the use of three different interventions involving over-the-counter hearing aids, it will lead to options that will increase access and affordability of hearing healthcare for adults with mild-to-moderate hearing loss.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
10/28/2024
Locations: The University of Alabama, Tuscaloosa, Alabama
Conditions: Hearing Loss
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Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures
NCT06477172
Recruiting
Non-interventional, multi-site, prospective, open-label, observational, real-world study of autologous hair follicle secretome use.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/25/2024
Locations: Skin Wellness Dermatology, Birmingham, Alabama
Conditions: Post Procedural Erythema
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Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations As Targets of a Treatment for PNES
NCT05096273
Recruiting
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of pediatric psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no medical explanation). 11-18-year-olds diagnosed with PNES will engage in twelve sessions of ReACT. Sense of control over actions will be measured by the magic and turbulenc... Read More
Gender:
ALL
Ages:
Between 11 years and 18 years
Trial Updated:
10/22/2024
Locations: Sparks Center Office of Psychiatric Research, Birmingham, Alabama
Conditions: Convulsion, Non-Epileptic
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