Alabama is currently home to 1241 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Birmingham, Mobile, Huntsville and Anniston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
NCT04069312
Recruiting
A multi-center, randomized, 72-month, parallel- group, non-inferiority, phase III study to compare the effectiveness of roflumilast (Daliresp, 500 mcg quaque die (QD) or alternate regimen) therapy versus azithromycin (250 mg QD, 500 mg QD three times per week, or alternate regimen) to prevent hospitalization or death in a patients at high risk for COPD exacerbations.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
06/06/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Chronic Obstructive Pulmonary Disease Severe, Chronic Bronchitis
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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
NCT06263426
Recruiting
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Hiv
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Histiocytic Disorder Follow-up Study
NCT05915208
Recruiting
The purpose of the study is to describe the burden of chronic health conditions, psychological dysfunction, chronic pain, healthcare utilization, worse health-related quality of life, overall mortality, and cause-specific mortality among individuals with histiocytic disorders
Gender:
ALL
Ages:
Between 0 years and 89 years
Trial Updated:
06/03/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Histiocytosis, Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai Dorfman Disease, Xanthogranuloma, Malignant Histiocytoses
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Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis
NCT05898477
Recruiting
The purpose of the study is to describe Hemophagocytic lymphohistiocytosis (HLH) in patients with lymphoma to identify possible therapeutic strategies to improve overall survival of the patients with lymphoma associated hemophagocytic lymphohistiocytosis.
Gender:
ALL
Ages:
All
Trial Updated:
06/03/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Lymphoma, Hemophagocytic Lymphohistiocytoses
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Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Children's of Alabama, Birmingham, Alabama
Conditions: Bronchiolitis Acute Viral
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Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice
NCT06131021
Recruiting
Periodontitis is a bacterial inflammatory disease and antibiotic use is being empirically used as part of its treatment. However, a clinical practice guideline on periodontal treatment adjuncts published in 2015 identified weak evidence on the use of systemic antibiotics and large heterogeneity across small scale studies, suggesting that larger pragmatic clinical trials would benefit clinical decision making. This will be a prospective, randomized, placebo-controlled trial, stratified by practic... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/30/2024
Locations: University of Alabame, Birmingham, Alabama
Conditions: Periodontitis, Periodontal Diseases, Periodontal Pocket
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The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
NCT04334135
Recruiting
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen... Read More
Gender:
ALL
Ages:
Between 19 years and 75 years
Trial Updated:
05/28/2024
Locations: Kinesiology Building, Auburn, Alabama
Conditions: Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
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Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
NCT03884374
Recruiting
This mechanistic clinical trial proposes to test whether a five-day course of mindfulness meditation training (MMT) and tDCS, and their combination, can enhance pain modulatory balance and pain-related brain function, reduce clinical pain, among African Americans and non-Hispanic whites with knee osteoarthritis (OA). This approach will provide evidence that targeting stress and pain-related brain function will reduce OA-related pain and ethnic group differences therein.
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
05/28/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Osteoarthritis of Knee
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Minds and Mentors Program- R33
NCT05363371
Recruiting
The proposed research effort will: The purpose of this study is as follows: 1. Test the effectiveness of the Minds and Mentors Program in a group treatment trial in which individuals using medications for opioid use disorder (MOUD) will be randomized in blocks of five to receive either the Minds and Mentors Program (n=120) or Twelve Step Facilitation (n=120). 2. Determine whether the MiMP: a) improves adherence to MOUD b) reduces the rate of relapse and cravings c) decreases self-reported anxi... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/26/2024
Locations: Birmingham Veteran Affairs Medical Center, Birmingham, Alabama
Conditions: Opioid Use Disorder, Substance Use Disorders, Medication Assisted Treatment
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Multisite Implementation of COMPRENDO
NCT06055296
Recruiting
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting implementation. This study will test the impact of COMPRENDO, a peer-navigation intervention, vs. usual care on accrual to childhood cancer therapeutic clinical trials and parental informed consent out... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Children's of Alabama/University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Pediatric Cancer
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ConsideRAte Study - Splenic Stimulation for RA
NCT05003310
Recruiting
This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories. The study will consist of 4 study periods, including a Randomized Control Trial period (Period 1), an Open Label period (Period 2), a Treat-to-target period (Period 3), and a Long-term Follow-up period (Period 4). Participants eligible for implant will have active r... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
05/20/2024
Locations: Pinnacle Research Group, LLC, Anniston, Alabama
Conditions: Rheumatoid Arthritis
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Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
NCT05161169
Recruiting
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks. The study will enroll a diverse cohort of 500 healthy infants and their parents from Boston, MA; New York City, NY; and Birmingham, AL. A small blood sample will be collected from each infant, and whole genome sequencing will be performed in 1/2 of the cohort following a randomized controlled trial design. 3 months later, the randomization status and... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
05/14/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Genetic Predisposition to Disease, Hereditary Diseases
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