There are currently 173 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and Pennsylvania.
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
NCT05562167
Recruiting
The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular ejection fraction <45%). The investigators hypothesize that both acute and chronic dosing of 10mmol of KNO3 will improve exercise performance in HFrEF. To test this hypothesis, the investors will perf... Read More
Gender:
All
Ages:
Between 19 years and 79 years
Trial Updated:
05/24/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Heart Failure
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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
NCT03142152
Recruiting
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona +69 locations
Conditions: Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
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Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
NCT04160000
Recruiting
Heart failure (HF) with preserved left ventricular function (pEF) is difficult clinical syndrome to treat effectively with few evidence based therapies. Atrial fibrillation (AF) is now an important co-morbidity being observed in 43% of patients with HFpEF. Rhythm control has not been studied in this population. Catheter ablation and antiarrhythmic drugs are rhythm control therapies that have been used for treatment of AF without HF or HF with reduced systolic function but have not been widely ap... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2024
Locations: Northern Arizona Health Care, Flagstaff, Arizona +8 locations
Conditions: Atrial Fibrillation, Heart Failure, Diastolic Heart Failure
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Cardiovascular Health Improvement Project
NCT02306200
Recruiting
The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.
Gender:
All
Ages:
All
Trial Updated:
05/22/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Aortic Aneurysm, Aortic Dissection, Bicuspid Aortic Valve (BAV), Heart Failure, Cardiovascular Diseases
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Heart Failure Precision Medicine Study
NCT04196842
Recruiting
The study aims to test the hypothesis that multi-omics studies can identify Heart Failure profiles at risk of adverse outcomes and evaluate a telemonitoring intervention in the optimization of guideline-directed medical therapy.
Gender:
All
Ages:
21 years and above
Trial Updated:
05/22/2024
Locations: UC Davis Medical Center, Sacramento, California
Conditions: Heart Failure
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The Re-Prosper HF Study
NCT04551222
Recruiting
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of physical and mental health status and carries a high risk of mortality. Even though significant progress has been made in understanding the disease process, currently, its management and treatment is limited. The investigators have discovered that a commonly used drug for the treatment of gout can be repurposed for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts +4 locations
Conditions: Heart Failure
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HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
NCT06425848
Recruiting
The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulatory hemodynamics monitoring and HF (Heart Failure) therapies. The data collected will be used for retrospective studies, quality improvement, identifying research cohorts, and member-initiated research.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/21/2024
Locations: Scripps Health, La Jolla, California +11 locations
Conditions: Heart Failure
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A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2
NCT05737940
Recruiting
This study is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart failure (HF) and pulmonary hypertension (PH) Group 2
Gender:
All
Ages:
Between 18 years and 130 years
Trial Updated:
05/21/2024
Locations: Research Site, Beverly Hills, California +63 locations
Conditions: Pulmonary Hypertension (World Health Organization Group 2), Heart Failure
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Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
NCT05990296
Recruiting
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life. Despite convincing data that evidenced-based, guideline-directed medical therapies (GDMT) improve mortality and heart failure-related events, there remains insufficient utilization of these life-saving drugs (evidence-based beta-blockers (EBBB), angiotensin-neprilysin inhibitors (ARNI)/ angiotensin c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/20/2024
Locations: Geisinger Cardiology Clinics, Danville, Pennsylvania
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction
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A Study of Ponsegromab in People With Heart Failure
NCT05492500
Recruiting
The primary purpose of this clinical trial is to compare the effects of study medicine (Ponsegromab/PF-06946860) with a placebo (an injection that looks like the study medicine but does not contain the active medicine) to find out if the study medicine is better than the placebo (an injection that looks like the study medicine but does not contain the active medicine) for treatment of symptoms related to heart failure. Participants will not know which treatment group they are assigned to. Most p... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Eastern shore Research Institute LLC, Fairhope, Alabama +138 locations
Conditions: Heart Failure
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Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
NCT06215586
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Cardurion Investigative Site, Little Rock, Arkansas +7 locations
Conditions: Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
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A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)
NCT06215911
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with reduced ejection fraction.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Cardurion Investigative Site, Little Rock, Arkansas +8 locations
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Cardiovascular Diseases, Heart Diseases
Register for Updates