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Heart Failure Clinical Trials
A listing of 171 Heart Failure clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
49 - 60 of 171
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There are currently 171 active clinical trials seeking participants for Heart Failure research studies. The states with the highest number of trials for Heart Failure participants are California, Florida, Texas and New York.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Dilated Cardiomyopathy (DCM) Research Study
Recruiting
If you are identified as eligible for investigational genetic testing, you will be sent a saliva collection kit to your home. Once you have completed and returned your kit to Sano Genetics, your sample will be tested for a specific genetic pathway called BAG3.
Investigational genetic testing can help you better understand your body and its needs, as well as how DCM may be passed down in your family. Those who are identified as having a variant in the BAG3 gene will be referred to an upcoming clinical trial.
Investigational genetic testing can help you better understand your body and its needs, as well as how DCM may be passed down in your family. Those who are identified as having a variant in the BAG3 gene will be referred to an upcoming clinical trial.
Conditions:
Dilated Cardiomyopathy (DCM)
Cardiovascular Diseases
Cardiomyopathy
Cardiovascular Disease
Heart Failure
Featured Trial
Heart Failure Clinical Trial
Recruiting
You or someone you love may be eligible for a heart failure clinical study. Eligible participants will receive study-related assessments, care, and treatment at no cost. You may be reimbursed for travel while participating. See if you are eligible.
Conditions:
Heart Failure
Congestive Heart Failure
Chronic Heart Failure
Heart Failure
Congestive
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Recruiting
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Recruiting
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Dignity Health Research Institute at Mercy Gilbert and Chandler Regional Medical Centers, Gilbert, Arizona +68 locations
Conditions: Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
Recruiting
This research project is relevant to public health because both heart failure (HF) and mild cognitive impairment (e.g., trouble remembering and concentrating beyond normal aging) are highly prevalent among older adults in the United States. Despite advances in health care, there are no effective interventions for treating cognitive impairment in HF, which if left untreated, leads to suboptimal health, quality of life, and shorter survival. Therefore, the investigators propose to test the effect... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/01/2025
Locations: Indiana University, Indianapolis, Indiana
Conditions: Heart Failure, Mild Cognitive Impairment
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART)
Recruiting
End-stage heart failure (HF) is a progressive illness with a mortality rate similar to most advanced cancers.Roughly 5% of patients with HF have end-stage disease that is refractory to medical therapy (stage D heart failure). When patients reach this point in their disease, the only treatments known to prolong life are cardiac transplantation or left ventricular assist devices. In patients who do not qualify for these options, or elect a palliative approach, inotropes are frequently used to impr... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/25/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Heart Failure
Pilot Study Lp299v Supplementation in Chronic Heart Failure
Recruiting
The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular endothelial function in humans with heart failure and reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) who have evidence of residual inflammation based on an elevated C-reactive protein level. This will be done in the setting of a random... Read More
Gender:
ALL
Ages:
Between 21 years and 89 years
Trial Updated:
04/24/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
Recruiting
The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with chronic stable preserved ejection fraction (HFpEF) and systemic inflammation. The use of LoDoCo in this study is considered investigational as it has not been approved by the Food and Drug Administration (FDA) for the treatment of exercise capacity in patients with HFpEF.
Par... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/23/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Heart Failure, Inflammation
The Re-Prosper HF Study
Recruiting
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System.
It is associated with severe impairment of physical and mental health status and carries a high risk of mortality. Even though significant progress has been made in understanding the disease process, currently, its management and treatment is limited.
The investigators have discovered that a commonly used drug for the treatment of gout can be repurposed for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts +4 locations
Conditions: Heart Failure
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
Recruiting
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist device (LVAD) implantation amongst patients with cardiogenic shock. Advanced therapies such as OHT and VADs in the heart failure (HF) population may promote skeletal muscle mass and subsequent quality of life, but there is a lack of literature assessing muscle mass changes in... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/18/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Heart Failure, Muscle Atrophy, Skeletal Muscle Atrophy, Cardiogenic Shock
Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction
Recruiting
Heart failure (HF) affects more than 6 million adults in the U.S. alone, with increasing prevalence. Cardiovascular congestion with resultant limitation in physical activity is the hallmark of chronic and decompensated HF. The current HF physiologic model suggests that congestion is the result of volume retention and, therefore, therapies (such as diuretics) have generally been targeted at volume overload. Yet therapeutic approaches to reduce congestion have failed to show significant benefit on... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/16/2025
Locations: Duke, Durham, North Carolina
Conditions: Heart Failure
TEXT4HF: A Randomized Controlled Trial of a Tailored Text Messaging Intervention to Improve Self-Care in Older Adult Patients With Heart Failure
Recruiting
The goal of this study is to determine whether an individually tailored text messaging intervention can improve self-care in older adult patients with heart failure. The main question it aims to answer are:
* Is a tailored text messaging intervention feasible and acceptable among older adult patients with heart failure?
* Does tailored text messaging improve self-care in adult patients with heart failure?
Participants will be randomly assigned to one of two groups for 12 weeks: 1) intervention... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/16/2025
Locations: University of Illinois, Chicago, Chicago, Illinois
Conditions: Heart Failure
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
Recruiting
This retrospective, non-randomized cohort study will evaluate how well the Cordella PA Sensor System works compared to standard medication treatment in people with chronic heart failure. The study will track patients for two years to see if those using the Cordella system have fewer deaths and hospitalizations related to heart failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2025
Locations: Endotronix, Naperville, Illinois
Conditions: Heart Failure NYHA Class III, Heart Failure
Pulmonary Artery Catheter in Cardiogenic Shock Trial
Recruiting
The primary objective of the PACCS trial is to assess if early invasive hemodynamic assessment and ongoing management with a PAC in patients with cardiogenic shock due to acutely decompensated heart failure (AHDF-CS) is associated with lower in-hospital mortality risk compared to the current standard of care with no or delayed PAC assessment.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/14/2025
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Cardiogenic Shock, Heart Failure
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
Recruiting
The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular ejection fraction \<45%). The investigators hypothesize that both acute and chronic dosing of 10mmol of KNO3 will improve exercise performance in HFrEF. To test this hypothesis, the investors will per... Read More
Gender:
ALL
Ages:
Between 19 years and 79 years
Trial Updated:
04/02/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Heart Failure
49 - 60 of 171