There are currently 50 active clinical trials seeking participants for Migraine research studies. The states with the highest number of trials for Migraine participants are Florida, California, Texas and New York.
Determining the Utility of a Behavioral Intervention in Chronic Migraine
Recruiting
This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Mayo Clinic, Phoenix, Arizona
Conditions: Migraine, Headache, Migraine Disorders, Chronic Migraine, Lifestyle Factors, Headache Disorders
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Recruiting
Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances. In this natural history study, researchers would like to learn more about the connection between exercise and mental health in people with and without mood disorders. Objective: To better understand relationships among physical activity, sleep, and mental health. Eligibility: People aged 12 to 60 years wit... Read More
Gender:
ALL
Ages:
Between 12 years and 70 years
Trial Updated:
06/25/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Bipolar Disorder, Major Depression, Migraine
Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli
Recruiting
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * How does brain activity contribute to VSS? Participants will: 1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function. 2. Make visual judg... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/11/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Visual Snow Syndrome, Migraine, Healthy
Responding With Evidence and Access for Childhood Headaches
Recruiting
This comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for youth with migraine. The focus is on applying evidence-based care and enhancing access to it. CBT via telehealth while taking a clinically-prescribed, pill-based prevention therapy (amitriptyline) will b... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
06/11/2025
Locations: University of Alabama at Birmingham Children's of Alabama, Birmingham, Alabama +13 locations
Conditions: Headache, Headache Disorders, Headache, Migraine, Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura, Chronic Migraine
Treatment for Migraine and Mood
Recruiting
The researchers propose a three-arm pilot study of Mindfulness-Based Cognitive Therapy (MBCT) delivered via telephone (MBCT-T), video (MBCT-V) or Enhanced Usual Care (EUC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: Albert Einstein College of Medicine, Bronx, New York +2 locations
Conditions: Migraine, Depressive Symptoms
BE WELL With Migraine: Brain Education and WELLness With Migraine
Recruiting
The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all their medications during this study. Information from this study may help determine how to better treat migraine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2025
Locations: Cambridge Health Alliance - Center for Mindfulness and Compassion, Cambridge, Massachusetts +2 locations
Conditions: Migraine
Omega-3 Supplementation for Pediatric Migraine
Recruiting
The purpose of the study is to assess the biochemical and clinical effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation in youth suffering from migraine, including its effects on migraine disability, psychological distress, and overall quality of life. This study duration 12 weeks.
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
05/22/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Migraine
Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
Recruiting
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
05/14/2025
Locations: University Medical Center of El Paso, EL Paso, Texas
Conditions: Migraine
Emgality for Migraine in Breastmilk
Recruiting
The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who were or were not breastfed after maternal treatment. In this prospective observational study, the study team proposes to prospectively collect serial milk samples from 30 adult women who are treated w... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/04/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Migraine
Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized Trial
Recruiting
* This two-stage clinical trial will assess a novel combination therapy for acute migraine. In Stage 1 (factorial), participants will receive the combination, each individual component, or placebo. In Stage 2 (dose-finding), they will test three doses of the combination. Before both stages, participants will complete a run-in period, documenting a migraine attack without study medication. They will then treat one migraine attack in each stage. * 4 visits * Requirements: Migraine Diagnosis. BMI b... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/20/2025
Locations: Keystone Clinical Research, North Miami, Florida
Conditions: Migraine
A Trial Investigating Lu AG09222 With Ubrogepant in Participants With Migraine
Recruiting
The main goal of this trial is to learn more about the safety and tolerability of Lu AG09222 when taken together with ubrogepant. This includes looking for any new or worsening medical issues the participants have with the treatment. During the trial, participants with migraine will receive ubrogepant oral tablets and an injection of either Lu AG09222 or a placebo.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/13/2025
Locations: Clinical Neuroscience Solutions, Orlando, Florida +3 locations
Conditions: Migraine
Exploring the Effect of the Transcendental Meditation® Technique on Migraine Frequency and Functionality: a Single Arm Study
Recruiting
This research will explore the effect of the Transcendental Meditation® Technique on migraine intensity and frequency. It will be a single-arm pilot study involving 30 participants recruited from migraine treatment facilities and support groups in the US.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/27/2025
Locations: Georgetown Headache Center and DC area, Washington, District of Columbia
Conditions: Migraine, Migraine with or Without Aura