There are currently 45 active clinical trials seeking participants for Rheumatoid Arthritis research studies. The states with the highest number of trials for Rheumatoid Arthritis participants are Florida, California, Texas and Pennsylvania.
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
NCT03276923
Recruiting
This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.
Gender:
FEMALE
Ages:
All
Trial Updated:
01/24/2025
Locations: Duke University, Durham, North Carolina
Conditions: Autoimmune Diseases, Pregnancy Related, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis, Sjogren's Syndrome, Scleroderma
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Atherosclerosis in Rheumatoid Arthritis and Lupus: Restoring Cholesterol Balance
NCT01180361
Recruiting
Hypothesis: SLE and RA increase risk of myocardial infarction (MI, heart attack). Immune reactants in the circulation of SLE patients downregulate cholesterol efflux proteins 27-hydroxylase and ABCA1 and upregulate scavenger receptor CD36, thus encouraging cholesterol accumulation. Adenosine A2A receptor agonist or statin treatment of cells exposed to SLE plasma (or immune complexes or cytokine-enriched plasma fractions from SLE patients) may ameliorate inflammatory properties of their plasma, l... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2024
Locations: NYU Langone Hospital - Long Island, Mineola, New York
Conditions: Rheumatoid Arthritis
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Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders
NCT05718583
Recruiting
This study is a pilot, proof of concept study to determine the effects of administering an oral short-chain fatty acid (SCFA) supplement to Rheumatoid Arthritis (RA) patients with inadequate response to methotrexate (MTX). The study will include up to 35 participants to obtain a sample size of at least 25 participants taking the oral supplement. The researchers hypothesize that oral SCFA will change the participants' gut microbiome and regulatory immune responses. Clinical data to assess for adv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/17/2024
Locations: NYU Langone Health Orthopedic Center, New York, New York
Conditions: Rheumatoid Arthritis
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Dynamic Treatment Regiments for Glucocorticoid Tapering
NCT06072768
Recruiting
The purpose of this clinical trial is to better understand how people with rheumatoid arthritis (RA) respond to gradual dose reduction, or "tapering", of steroid medications like prednisone. Some people with RA have symptoms when steroid dose is reduced, while others don't. This trial will look at different patient characteristics, including levels of inflammation in the body, differences in the way the brain processes sensory information, and certain hormone levels, to help researchers better u... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan +1 locations
Conditions: Rheumatoid Arthritis
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Rheumatology Diet Study
NCT06339957
Recruiting
This study aims to collect information on rheumatology patients' dietary habits, autoimmune disease activity, dietary changes, disease symptom improvements, and perceptions on their dietary habits and how it affects their autoimmune disease. The main objective is to see if rheumatology patients change their dietary habits after their diagnosis of an autoimmune disease and if it subjectively improved their disease symptoms. It will also look at rheumatology patients' expectations for their rheuma... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/03/2024
Locations: UCF Health Clinics, Orlando, Florida
Conditions: Diet Habit, Rheumatologic Disease, Autoimmune Diseases, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Dermatomyositis/Polymyositis, Sjogren's Syndrome, Systemic Lupus Erythematous, Scleroderma, Fibromyalgia
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Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD
NCT05936970
Recruiting
The primary goal of this study is to assess a cfDNA-based blood test using genetic, transcriptomic and/or epigenetic information to help doctors predict the best treatment options for rheumatoid arthritis (RA) patients with inadequate response or intolerance to previous therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, North Carolina
Conditions: Rheumatoid Arthritis
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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
NCT06201416
Recruiting
This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/25/2024
Locations: Mayo Clinic, Scottsdale, Arizona +7 locations
Conditions: Rheumatoid Arthritis
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Rheumatoid Arthritis Shared Decision Making
NCT05530694
Recruiting
Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform effective ways to implement this practice in the care of Veterans with RA. The purpose of this project is to evaluate the effectiveness of a multi-component shared decision making intervention on RA disease activity, adherence to RA medications and patient... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: San Francisco VA Medical Center, San Francisco, CA, San Francisco, California +3 locations
Conditions: Rheumatoid Arthritis
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Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.
NCT06581562
Recruiting
This study will evaluate the safety and activity of AB-101 in combination with rituximab in B-cell associated autoimmune diseases where rituximab is currently FDA approved (e.g., Rheumatoid Arthritis (RA), Pemphigus Vulgaris (PV), Granulomatosis with polyangiitis (GPA)/microscopic polyangiitis (MPA) as a therapeutic, or is recommended (e.g., in Systemic Lupus Erythematosus (SLE) as a cornerstone for disease management.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: IRIS Research and Development, LLC, Plantation, Florida
Conditions: Rheumatoid Arthritis, Pemphigus Vulgaris, Granulomatosis With Polyangiitis, Systemic Lupus Erythematosus
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CorEvitas Rheumatoid Arthritis (RA) Drug Safety & Effectiveness Registry
NCT01402661
Recruiting
This prospective, non-interventional research registry is designed to study the comparative effectiveness and comparative safety of approved treatments for RA in a cohort of patients cared for by rheumatologists across North America. Secondary objectives include analyzing the epidemiology and natural history of the disease, its comorbidities, and current treatment practices.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2024
Locations: CorEvitas, LLC, Waltham, Massachusetts
Conditions: Rheumatoid Arthritis
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ConsideRAte Study - Splenic Stimulation for RA
NCT05003310
Recruiting
This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories. The study will consist of 4 study periods, including a Randomized Control Trial period (Period 1), an Open Label period (Period 2), a Treat-to-target period (Period 3), and a Long-term Follow-up period (Period 4). Participants eligible for implant will have active r... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
05/20/2024
Locations: Pinnacle Research Group, LLC, Anniston, Alabama +13 locations
Conditions: Rheumatoid Arthritis
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Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
NCT04748809
Recruiting
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with rheumatoid arthritis, and the role of microbiome and circulating metabolites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2024
Locations: UCSD, La Jolla, California
Conditions: Rheumatoid Arthritis
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