Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
Recruiting
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person eats and weight loss over 4 weeks. It will also compare weight changes in people who attend weight loss counseling sessions and those who do not over this period of time. Obese, non-diabetic people between 18 and 60 years of age who are in good health and who live in the... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
11/17/2023
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Electric Stimulation Therapy, Obesity, Weight Loss, Eating
Sleep Goal-focused Online Access to Lifestyle Support
Recruiting
The overall goal of the study is to develop a novel weight loss intervention for postpartum people by providing strategies to improve sleep, diet, and physical activity behaviors. In this study, we will recruitment and enroll 40 postpartum people and randomize them to receive the Sleep GOALS intervention or education control to evaluate the intervention's feasibility, acceptability, and preliminary efficacy.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
11/01/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Weight Loss, Weight, Body
Dyad Plus Effectiveness
Recruiting
The purpose of this research is to determine the effectiveness of a coordinated program (Dyad Plus) that would help to facilitate self-monitoring, positive communication, joint problem solving, and social support to increase physical activity, healthy eating, and weight loss. Participants of the Brenner FIT (Families In Training) pediatric weight management program and their parent/guardian will co-enroll in weight loss programs. Parents/guardians will receive the components of By Design Essenti... Read More
Gender:
All
Ages:
Between 13 years and 65 years
Trial Updated:
10/24/2023
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Weight Loss, Pediatric Obesity, Overweight Adolescents, Parent-Child Relations, Family and Household
Teen Weight Control
Recruiting
The prevalence of obesity in adolescents is remarkably high, with 38.7% of youth 12-15 years of age and 41.5% of 16-19 year olds meeting criteria for overweight or obesity. Behavioral weight control interventions for adolescents have had limited impact on this field and there is considerably more that needs to be done. Notably, adolescents who have difficulty managing their feelings have been found to consume higher caloric foods and report greater amounts of sedentary time. Poor emotion managem... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
10/18/2023
Locations: University of Oregon, Eugene, Oregon +2 locations
Conditions: Adolescent Obesity, Weight Loss
TRE: Microbiome, Metabolic Health and Bone
Recruiting
In the Time-Restricted Eating: Microbiome and Bone (TREMBO) study, the primary goal is to determine the effect of time-restricted eating with caloric restriction compared to caloric restriction alone on body weight, the gut microbiota, and bone health in older women who are overweight or obese.
Gender:
Female
Ages:
Between 50 years and 79 years
Trial Updated:
10/17/2023
Locations: Rutgers University - NJ Inst Food Nutrition & Health, New Brunswick, New Jersey
Conditions: Weight Loss, Time Restricted Feeding, Bone Loss
VK2735 for Weight Management Phase 2
Recruiting
This is a phase 2, 13-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the safety, tolerability, weight loss efficacy, pharmacodynamic effects, and pharmacokinetics of VK2735 in adults who are obese (BMI ≥30 kg/m2) or who are overweight (BMI ≥27 kg/m2) with at least one weight-related co-morbid condition. VK2735 or matched placebo will be administered once weekly.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/28/2023
Locations: Viking Clinical Site #119, Birmingham, Alabama +19 locations
Conditions: Weight Loss
Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention
Recruiting
This optimization trial will examine three tracking (or "self-monitoring") strategies for weight loss -- tracking dietary intake, steps, and/or body weight -- all delivered through digital health tools. The purpose of the study is to evaluate the combination of these strategies that maximizes 6-month weight loss in the context of a standalone digital health intervention for adults with overweight or obesity. The investigators will recruit 176 total participants to the trial. Recruitment will oc... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2023
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Obesity, Overweight, Weight Loss, Health Behavior
DiAL Health Research Study
Recruiting
The purpose of this study is to conduct a five-arm pilot and feasibility trial in healthy, young individuals without obesity to evaluate the feasibility and efficacy of dietary intervention approaches to slow mechanisms of aging.
Gender:
All
Ages:
Between 25 years and 45 years
Trial Updated:
09/13/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama +1 locations
Conditions: Aging, Weight Loss, Treatment Adherence
Hepatic Energy Fluxes in NASH and NAS Patients
Recruiting
Diseases along the nonalcoholic fatty liver disease spectrum, which are tightly coupled to the obesity epidemic, are soon to become the commonest indication for liver transplantation in the United States. Bariatric surgery shows great promise in the treatment of these diseases. The studies proposed herein will be the first to measure in humans the relationships among (i) the liver's ability to burn fat and make glucose, two of its primary functions; (ii) the severity of nonalcoholic fatty liver... Read More
Gender:
All
Ages:
Between 40 years and 67 years
Trial Updated:
09/13/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: NASH - Nonalcoholic Steatohepatitis, NAS, Overweight or Obesity, Weight Loss, Bariatric Surgery Candidate
Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity
Recruiting
Approximately 70% of American adults have overweight/obesity, which increases risk of major medical issues and preventable death (Abdelaal et. al, 2017). Many individuals with overweight/obesity attempt to lose weight through behavioral strategies, e.g., adopting a reduced-calorie diet and/or increased physical activity. However, it is exceedingly difficult to consistently adhere to a reduced-calorie diet and high levels of physical activity; as such, most individuals attempting to lose weight v... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/10/2023
Locations: Health Lab, Psychology Department, Williams College, Williamstown, Massachusetts
Conditions: Obesity, Weight Loss
Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program
Recruiting
Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramatically underrepresented in weight loss programs. Attempts to modestly adapt standard weight loss programs have seen only minimal success. Mobile applications (mHealth apps) have attractive features, but have low male enrollment and poor efficacy as conventionally delivered. A gamified mHealth program offers the possibil... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/05/2023
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Obesity, Weight Loss
Metabolic Adaptations to Weight Loss With and Without Exercise
Recruiting
Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of adding exercise to a weight loss program will not only aid efforts to optimize more effective lifestyle interventions, but it can also uncover novel targets for the treatment/prevention of obesity-relat... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
08/19/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity, Metabolic Disease, Metabolic Syndrome, Insulin Sensitivity, Insulin Resistance, Weight Loss