There are currently 536 clinical trials in Gainesville, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Florida /ID# 144834, University of Florida Health Science Center - Gainesville, University of Florida Shands Cancer Center and University of Florida College of Medicine. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Clinical Orthopaedic Data Bank (Acute and Chronic)
NCT00411060
Recruiting
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.
Gender:
ALL
Ages:
All
Trial Updated:
08/05/2025
Locations: UF&Shands Orthopaedics and Sports Medicine Institute, Gainesville, Florida
Conditions: Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
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Citadel Embolization Device Study
NCT04057352
Recruiting
The purpose of this study is to gather safety and effectiveness data on Stryker Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the Citadel Embolization Device), when used with Target Detachable Coils, in the treatment of wide-neck intracranial aneurysms.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Unruptured Wide-neck Aneurysms
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HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma
NCT04903080
Recruiting
This is a Phase I study to evaluate the safety profile of a type of immune therapy called HER2 CAR T cells (short for HER2 chimeric antigen receptor T cells). In addition to looking for side effects, we will study how well this treatment works against a brain tumor called ependymoma that has come back after treatment (recurrent) or has not responded well to treatment (progressive) in children. The HER2 CAR T cells used in this trial are made from the patient's own blood. A new gene, called the H... Read More
Gender:
ALL
Ages:
Between 1 year and 22 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Ependymoma
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Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
NCT05918861
Recruiting
This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile. Subjects will provide informed consent before any study-specific procedures are performed. A separate informed consent will be allowed for an initial pre-screening genetic testing. Subjects meeting the AA genotype will then consent to the full study and confirmatory genetic testing as required. Subject enrollment may... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/05/2025
Locations: Research Site, Gainesville, Florida
Conditions: Acute Coronary Syndrome
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Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation
NCT05721261
Recruiting
A novel temporary peripheral nerve stimulation system that delivers a single dose of electrical stimulation therapy for 1 hour will be evaluated for safety and effectiveness.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/05/2025
Locations: University of Florida Health, Gainesville, Florida
Conditions: Nerve Injury
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All-extremity Exercise During Breast Cancer Chemotherapy
NCT04914663
Recruiting
Currently, there are 3.5 million breast cancer survivors in the United States and this number is expected to increase dramatically. The proposed research will examine whether a novel exercise intervention for breast cancer patients who are undergoing chemotherapy protects against cardiovascular dysfunction. Findings may have implications for cardiovascular disease prevention in this population.
Gender:
FEMALE
Ages:
Between 18 years and 85 years
Trial Updated:
08/05/2025
Locations: Integrative Cardiovasculal Physiology Laboratory, University of Florida, Gainesville, Florida
Conditions: Breast Cancer
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Danon Disease Natural History Study
NCT06214507
Recruiting
The goal of this international observational study is to learn about the natural history of Danon disease in male patients \>8 years of age and female patients \<30 years of age. The key objectives include assessing change over time in cardiac structure (left ventricular mass and wall thickness), cardiac biomarkers, symptoms, and quality of life and the incidence of clinical events such as HF hospitalization, cardiac transplantation, and death.
Gender:
ALL
Ages:
8 years and above
Trial Updated:
08/05/2025
Locations: University of Florida College of Medicine, Gainesville, Florida
Conditions: Danon Disease
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A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.
NCT06588686
Recruiting
The ASPIRE trial is a 52 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of orally administered buloxibutid, either on top of stable IPF therapy or as monotherapy, are assessed in participants with IPF. Trial website: www.aspire-ipf.com
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/05/2025
Locations: University of Florida Health (UF Health), Gainesville, Florida
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
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Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma
NCT06262516
Recruiting
The goal of this study is to conduct the first randomized-controlled trial to determine the oncologic efficacy of lymph node dissection in participants with upper tract urothelial cell carcinoma. The main questions it aims to answer are: * To determine oncologic outcomes, specifically 2-year recurrence-free survival * To determine other oncologic outcomes including treatment-free, cancer-specific and overall survival * To determine time to recurrence and recurrence patterns * To determine use o... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
08/05/2025
Locations: University of Florida Health Science Center, Gainesville, Florida
Conditions: Urothelial Carcinoma
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Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
NCT06911229
Recruiting
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Parkinson Disease
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Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
NCT07009717
Recruiting
Great Toe Strength (GTS) is a potential clinical biomarker that has been associated with functional mobility and health; Additionally, GTS has been identified in the literature as one of the early symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this research study is to evaluate GTS in individuals with CIPN and healthy adults using ToeScale and see how it relates to nerve issues from chemotherapy. Additionally, we aim to assess the usability of the novel GTS assessm... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Chemotherapy-induced Peripheral Neuropathy (CIPN), Healthy
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Yeast Mannans and Stool Frequency
NCT06911177
Recruiting
Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Se... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2025
Locations: Department of Food Science and Human Nutrition, Gainesville, Florida
Conditions: Defecation Frequency
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