Efficacy and Safety of QGE031 (Ligelizumab) in Patients With Peanut Allergy
NCT04984876
Recruiting
This is a 52-week, Phase 3 multi-center, randomized, double-blind and placebo-controlled study to assess the safety and clinical efficacy of two dosing regimens of ligelizumab (240 mg and 120 mg) subcutaneous injection every 4 weeks (SCq4w) in participants with a medically confirmed diagnosis of IgE-mediated peanut allergy.
Gender:
All
Ages:
Between 6 years and 55 years
Trial Updated:
11/30/2023
Locations: Novartis Investigative Site, Atlanta, Georgia
Conditions: Allergy, Peanut
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Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
NCT04975997
Recruiting
This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM).
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Emory University, Atlanta, Georgia
Conditions: Multiple Myeloma
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A Study of BMS-986416 With and Without Nivolumab in Select Solid Tumors
NCT04943900
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug effects, drug levels and preliminary antitumor activity of BMS-986416 when administered alone and in combination with Nivolumab in participants with select advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Winship Cancer Institute, Emory University, Atlanta, Georgia
Conditions: Advanced Solid Tumors
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Clesrovimab (MK-1654) in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease (MK-1654-007)
NCT04938830
Recruiting
This study aims to evaluate the safety and tolerability of clesrovimab compared to palivizumab as assessed by the proportion of participants experiencing adverse events (AEs).
Gender:
All
Ages:
1 year and below
Trial Updated:
11/30/2023
Locations: Morehouse School Of Medicine ( Site 0049), Atlanta, Georgia
Conditions: RSV Infection
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A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
NCT04936542
Recruiting
This study is aiming to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to duration of response as the key secondary efficacy endpoint when used at optimal doses according to approved prescribing information of each product.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/30/2023
Locations: Emory University of School of Medicine, Atlanta, Georgia
Conditions: Upper Limb Spasticity
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Oral Omadacycline vs. Placebo in Adults With NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)
NCT04922554
Recruiting
The purpose of this study is to evaluate the efficacy, safety and tolerability of oral omadacycline as compared to placebo in the treatment of adults with Nontuberculous Mycobacterial (NTM) pulmonary disease caused by Mycobacterium abscessus complex (MABc)
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Emory University School of Medicine, Atlanta, Georgia
Conditions: Mycobacterium Infections, Nontuberculous, Mycobacterium Abscessus Infection, Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterial Pulmonary Infection
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Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)
NCT04895722
Recruiting
The purpose of this study is to assess the efficacy and safety of co-formulated pembrolizumab/quavonlimab versus other treatments in participants with MSI-H or dMMR Metastatic Stage IV Colorectal Cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: University Cancer & Blood Center, LLC ( Site 1521), Athens, Georgia
Conditions: Colorectal Cancer
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A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
NCT04736706
Recruiting
The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC). The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall survival (OS), in advanced cc... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: University Cancer & Blood Center, LLC ( Site 0057), Athens, Georgia
Conditions: Carcinoma, Renal Cell
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Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)
NCT04622007
Recruiting
Tomivosertib combined with pembrolizumab in Subjects with PD-L1 positive NSCLC
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: John B. Amos Cancer Center, Columbus, Georgia
Conditions: Non-small Cell Lung Cancer
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Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)
NCT04609878
Recruiting
This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
11/30/2023
Locations: Research Site, Adairsville, Georgia
Conditions: Asthma
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Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients
NCT04578834
Recruiting
The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of iptacopan (LNP023) at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2023
Locations: Novartis Investigative Site, Lawrenceville, Georgia
Conditions: IgA Nephropathy
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Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infection
NCT04350138
Recruiting
This is a Phase II, randomized, observer-blind, placebo-controlled, multi-site trial of the FDA licensed rMenB+OMV NZ vaccine, Bexsero. The targeted study population is men and women 18-50 years of age who are disproportionately vulnerable to N. gonorrhoeae infection. Approximately 2,200 participants are expected to be enrolled to achieve at least 202 evaluable participants. Data will be collected in an observer-blind manner. Study product recipients and study staff responsible for the evaluatio... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
11/30/2023
Locations: Emory University School of Medicine - The Ponce de Leon Center, Atlanta, Georgia
Conditions: Gonococcal Infection
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